Study of flavonoids/β-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation

Ficarra, R.; Tommasini, S.; Raneri, D.; Calabrò, Marco; Bella, M. R. Di; Rustichelli, Cecilia; Gamberini, Maria Cristina; Ficarra, P.

doi:10.1016/s0731-7085(02)00141-3

Cited by 176 publications

(83 citation statements)

References 18 publications

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“…Naringin was found to be a highly crystalline material as confirmed by various peaks in the diffractogram (a in Figure 4) in agreement with the work of Ficarra et al (2002). On the other hand, RMD was found to be represented by a fully amorphous halo (b in Figure 4).…”

Section: Powder X-ray Diffractionsupporting

confidence: 79%

Resistant maltodextrin as a shell material for encapsulation of naringin: Production and physicochemical characterization

Pai

Vangala

et al. 2015

Journal of Food Engineering

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Herein the potential of a relatively new water soluble fiber, resistant maltodextrin (RMD) to encapsulate grapefruit polyphenol, naringin, using spray drying was evaluated. Full factorial Design Of Experiments (DOE) for spray drying with two levels of fiber-naringin ratio and spray dryer inlet temperature was executed. Resulting powders were characterized with respect to particle size and morphology, crystallinity, thermal properties, moisture sorption and naringin aqueous solubility increase. A 60-80% encapsulation was achieved. Thermal and moisture sorption behaviors of these dispersions were found to be dominated by RMD. By varying fiber-naringin ratio and spray drying temperatures, naringin was able to disperse in amorphous form in RMD matrix, which led to 20-55% increase in aqueous solubility.Solubility enhancement was found to correlate positively with increasing fiber: naringin ratio and spray drying temperature due to multiple factors discussed in this study. In conclusion, fiber-polyphenol bicomponent nutraceutical was successfully developed based on a well-established encapsulation technology i.e. spray-drying.3

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Section: Powder X-ray Diffractionsupporting

confidence: 79%

Resistant maltodextrin as a shell material for encapsulation of naringin: Production and physicochemical characterization

Pai

Vangala

et al. 2015

Journal of Food Engineering

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“…Ethereal functional groups, as found for C-O-C vibrations in the fraction, were supported by the bands at 1102-1030 cm −1 , and the aromatic substitution patterns were confirmed by the presence of the vibration bands at 832-733 cm −1 ; this is attributed to both ortho-and meta-substitution of the hydroxyl groups on the phenyl ring. Phenol compounds with high concentration have been shown to have vibrational frequency characteristics at 3200-3400 cm −1 , which are usually broad [62]. The FTIR assay confirmed the presence of aromatic, phenyl, carbonyl, amide, hydroxyl, phenolic, and ethereal chemical groups, thereby corroborating the findings of [63].…”

Section: Discussionsupporting

confidence: 54%

“…It has been reported that the -OH phenolic compounds do have vibrational bands at 1200 and 1350 cm −1 [62]. The close proximity of these bands to those found in the fraction suggests that the n-hexane fraction of P. biglobosa bark under investigation may contain flavonoid constituents.…”

Section: Discussionmentioning

confidence: 84%

Synergistic Effects of n-Hexane Fraction of Parkia biglobosa (Jacq.) Bark Extract and Selected Antibiotics on Bacterial Isolates

2017

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Abstract:The incidence of resistance to commonly used antimicrobial agents by microbial pathogens demands increased effort in the development of effective ways of treating infections and diseases. The n-hexane fraction of lyophilized crude bark extract of Parkia biglobosa (Jacq.) was prepared and, in combination with selected antibiotics, assayed for antimicrobial activity against some selected bacterial pathogens using time-kill assay. Protein leakage analysis of the combined agents was performed using Bradford protein quantification method. Determination of active compounds present in the n-hexane fraction was done using Fourier Transform Infrared Spectroscopy (FTIR). While time-kill assay detected 43.33% synergy; 56.67% indifference and no antagonism at 1/2 × minimum inhibitory concentration (MIC), 1 × MIC exhibited 55% synergy, 45% indifference and no antagonism. Protein leakages from the cells of selected bacteria ranged from 1.20 µg/mL to 256.93 µg/mL. The presence of a phenyl group, an aromatic ring and phenolic compounds in the n-hexane fraction was confirmed at 2162 cm −1 -2020 cm −1 , 1605 cm −1 -1533 cm −1 and 1438 cm −1 -1444 cm −1 spectra peaks, respectively. The observed antibiotic−n-hexane fraction synergistic interaction revealed the improved antibacterial activity of the selected antibiotics. Hence, exploration of a combination of antibiotics with plant secondary metabolites is hereby advocated in the global quest for means of combating infectious diseases caused by multidrug-resistant pathogens.

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“…Humans are estimated to consume 1 g flavonoids per day. Several biological functions of flavonoids have been identified, however, their use in the pharmaceutical field is limited [14]. The role of dietary flavonoids against disease is promising.…”

Section: Discussionmentioning

confidence: 99%

Flavonoids from tartary buckwheat induce G<sub>2</sub>/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells

Duan

Jia

et al. 2014

ABBS

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The cytotoxicity and antioxidant activity on human hepatoma cell line HepG2 of three flavonoids homogenous compounds from tartary buckwheat seeds and bran, namely quercetin, isoquercetin, and rutin, were investigated. The total antioxidant competency detection results indicated that the antioxidant capacity of quercetin was the strongest in a biological response system. A [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay showed that quercetin exhibited the strongest cytotoxic effects against the HepG2 cell line. Flow cytometric analysis indicated that quercetin significantly increased the production of reactive oxygen species, and led to the G 2 /M phase arrest accompanied by an increase of apoptotic cell death after 48 h of incubation. Quercetin-induced cell apoptosis was shown to involve p53 and p21 up-regulation, Cyclin D1, Cdk2, and Cdk7 down-regulation. These results suggested that the induction of G 2 /M arrest, apoptosis, and cell death by quercetin may associate with increased expression of p53 and p21, decrease of Cyclin D1, Cdk2, and Cdk7 levels, and generation of reactive oxygen species in cells. This study will help to better understand and fully utilize medicinal resources of plant flavonoids.

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Study of flavonoids/β-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation

Cited by 176 publications

References 18 publications

Resistant maltodextrin as a shell material for encapsulation of naringin: Production and physicochemical characterization

Resistant maltodextrin as a shell material for encapsulation of naringin: Production and physicochemical characterization

Synergistic Effects of n-Hexane Fraction of Parkia biglobosa (Jacq.) Bark Extract and Selected Antibiotics on Bacterial Isolates

Flavonoids from tartary buckwheat induce G<sub>2</sub>/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells

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Study of flavonoids/β-cyclodextrins inclusion complexes by NMR, FT-IR, DSC, X-ray investigation

Cited by 176 publications

References 18 publications

Resistant maltodextrin as a shell material for encapsulation of naringin: Production and physicochemical characterization

Resistant maltodextrin as a shell material for encapsulation of naringin: Production and physicochemical characterization

Synergistic Effects of n-Hexane Fraction of Parkia biglobosa (Jacq.) Bark Extract and Selected Antibiotics on Bacterial Isolates

Flavonoids from tartary buckwheat induce G&lt;sub&gt;2&lt;/sub&gt;/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells

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Flavonoids from tartary buckwheat induce G<sub>2</sub>/M cell cycle arrest and apoptosis in human hepatoma HepG2 cells