2023
DOI: 10.3390/antiox12010183
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Study of Ferroptosis Transmission by Small Extracellular Vesicles in Epithelial Ovarian Cancer Cells

Abstract: Epithelial ovarian cancer (EOC) is the most lethal gynecological cancer. The current treatment for EOC involves surgical debulking of the tumors followed by a combination of chemotherapy. While most patients achieve complete remission, many EOCs will recur and develop chemo-resistance. The cancer cells can adapt to several stress stimuli, becoming resistant. Because of this, new ways to fight resistant cells during the disease are being studied. However, the clinical outcomes remain unsatisfactory. Recently, f… Show more

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Cited by 8 publications
(2 citation statements)
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“…Furthermore, sEVs have the ability to modulate the metabolic state of cells by regulating glutathione metabolism and lipid peroxidation . Hence, the utilization of sEV-mediated cell-to-cell communication presents a promising strategy in the fight against ovarian cancer, as evidenced by previous research (Alarcón-Veleiro et al, 2023).…”
Section: Therapies Targeting Ferroptosis-related Signaling Pathways A...mentioning
confidence: 79%
“…Furthermore, sEVs have the ability to modulate the metabolic state of cells by regulating glutathione metabolism and lipid peroxidation . Hence, the utilization of sEV-mediated cell-to-cell communication presents a promising strategy in the fight against ovarian cancer, as evidenced by previous research (Alarcón-Veleiro et al, 2023).…”
Section: Therapies Targeting Ferroptosis-related Signaling Pathways A...mentioning
confidence: 79%
“…Although 100 µM of extracellular iron is a condition that is never detected in vivo, our data support the importance of extracellular iron in the behavior of tumor cells. It is well known that cancer cells can release small extracellular vesicles that allow the transport of substances, among which is iron, from the cells themselves to communicate with their environment [39].…”
Section: Discussionmentioning
confidence: 99%