Study of Factors Affecting Drug Extraction during Continuous Hemofiltration and Hemodiafiltration, and the Contribution of Extraction to Systemic Clearance
Abstract:The aim of this study was to elucidate the factors aŠecting dialysis clearance and the need for additional doses of drugs during and after continuous hemoˆltration (CHF) and hemodiaˆltration (CHDF). We performed a literature search of MEDLINE using the terms hemoˆltration OR hemodiaˆltration AND pharmacokinetics to obtain the clearances of CHF and CHDF in a clinical setting. The relationships between molecular weight, the unbound fraction (fuB), ultraˆltration ‰ow rate (UFR) and dialysis ‰ow rate were analyzed… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.