Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study

Yu, Xiaobing; Huang, Wei; Zhao, Dewei; Yang, Ke; Tan, Lili; Zhang, Xiuzhi; Li, Junlei; Zhang, Meng; Zhang, Shuo; Liu, Tao; Wu, Baolin; Qu, Mingjia; Duan, Ruimeng; Yuan, Yashuai

doi:10.1016/j.colsurfb.2018.10.054

Cited by 21 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with other samples, the extracts of MACP had no significant damage to HUVECs, which might indicate that MACP sample could not inhibit the formation of blood vessels in the skin tissue. 39 The cell staining with phalloidin could reflect the effects of the materials on the cells. 40,41 Compared to cell morphology with control, it was not much different from the control samples.…”

Section: Discussionmentioning

confidence: 99%

The effect of composite PHB coating on the biological properties of a magnesium based alloy

Liang

Liu

et al. 2021

J Biomater Appl

View full text Add to dashboard Cite

Magnesium alloys have been widely investigated as biodegradable cardiovascular temporal implants due to their better mechanical properties and biocompatibility, but the rapid degradation limited its application. In this study, the anodic oxidation-Cu structure was used to improve the adhesive strength and stability between poly-β-hydroxybutyrate (PHB) and magnesium alloys, and the effects of anodic oxidation magnesium alloys with copper film and PHB film (MACP) on human umbilical vein endothelial cells (HUVECs), blood compatibility and antibacterial properties were investigated in this research. As the result, the MACP structure had a stable structure and better corrosion resistance, and significant antibacterial properties. The coating would not affect the original excellent biocompatibility of the magnesium alloy. It was indicated that MACP was a potential surface modification strategy for vascular stents candidate material.

show abstract

Section: Discussionmentioning

confidence: 99%

The effect of composite PHB coating on the biological properties of a magnesium based alloy

Liang

Liu

et al. 2021

J Biomater Appl

View full text Add to dashboard Cite

show abstract

“…The cell viability of the MG plate decreased to 96.6% after 24 h of cultivation and increased to 99.2% after 7 days with the increase of cultivation time, which was attributed to the release of Mg 2+ from degradation to promote cell growth and multiplication. 37,38 Similarly, the PHA plate also exhibited a higher cell viability, and the addition of Mg-MGNWs to the porous PHA maintained a cell viability above 96%. The addition of Mg-based Mg-MGNWs is beneficial for early cell diffusion and proliferation, which are fundamental processes for cell growth and differentiation.…”

Section: Degradable Biocompatibility Ofmentioning

confidence: 96%

Design of Light-Driven Biocompatible and Biodegradable Microrobots Containing Mg-Based Metallic Glass Nanowires

Huang,

Yu,

et al. 2024

ACS Nano

View full text Add to dashboard Cite

Light-driven microrobots capable of moving rapidly on water surfaces in response to external stimuli are widely used in a variety of fields, such as drug delivery, remote sampling, and biosensors. However, most lightdriven microrobots use graphene and carbon nanotubes as photothermal materials, resulting in poor biocompatibility and degradability, which greatly limits their practical bioapplications. To address this challenge, a composition and microstructure design strategy with excellent photothermal properties suitable for the fabrication of light-driven microrobots was proposed in this work. The Mg-based metallic glass nanowires (Mg-MGNWs) were embedded with polyhydroxyalkanoates (PHA) to fabricate biocompatible and degradable microrobots with excellent photothermal effect and complex shapes. Consequently, the microrobot can be precisely driven by a near-infrared laser to achieve high efficiency and remote manipulation on the water surface for a long period of time, with a velocity of 9.91 mm/s at a power density of 2.0 W/cm 2 . Due to the Marangoni effect, programmable and complex motions of the microrobot such as linear, clockwise, counterclockwise, and obstacle avoidance motions can be achieved. The biocompatible and degradable microrobot fabrication strategy could have great potential in the fields of environmental detection, targeted drug delivery, disease diagnosis, and detection.

show abstract

“…The main advantage of Mg/PLA composite is the opportunity to tailor mechanical, degradation, and biological properties by changing the amount, size, distribution and orientation of Mg reinforcement within the PLA matrix. Particularly for orthopedic fixation devices, Mg/PLA is attractive as many reports showed the osteogenic effect of Mg ions [65],…”

Section: Introductionmentioning

confidence: 99%

“…braided wire [70], Mg rod [72], Mg sheet [73]. with hydrofluoric acid [45][67], saline coupling agents [65] and surfactants [88] as well as electrochemical treatments by anodizing [72] and plasma-electrolytic oxidation (PEO) [69][89]. In fact, orthopedic fixation devices (plates and screws) of Mg modified by PEO have already shown excellent in vivo performance with enhanced bone formation around the implant [26][90].…”

Section: Introductionmentioning

confidence: 99%

Bioabsorbable Composite Laminates of Poly‐Lactic Acid Reinforced with Surface‐Modified Mg Wires for Orthopedic Implant Applications

Ali,

González,

Kopp

et al. 2024

Adv Eng Mater

View full text Add to dashboard Cite

Unidirectional and multidirectional laminates of Mg wire‐reinforced PLA‐matrix composites were manufactured by an improved compression molding strategy that allows excellent control on the position and orientation of the wires. Two different types of Mg wires, with and without surface modification by continuous plasma electrolytic oxidation were used, the former to improve the interfacial strength and to reduce the degradation rate of Mg wires in biological environments. The mechanical properties of the constituents as well as of composites were measured before and after degradation by immersion in simulated body fluids and the corresponding deformation, fracture and degradation mechanisms were analyzed in detail. It was found that the presence of the Mg wires improved the mechanical behavior in tension and compression of unidirectional composites in the longitudinal direction (close to cortical bone) and that quasi‐isotropic laminates with tailored properties could be designed from the data of unidirectional composites.This article is protected by copyright. All rights reserved.

show abstract

Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study

Cited by 21 publications

References 35 publications

The effect of composite PHB coating on the biological properties of a magnesium based alloy

The effect of composite PHB coating on the biological properties of a magnesium based alloy

Design of Light-Driven Biocompatible and Biodegradable Microrobots Containing Mg-Based Metallic Glass Nanowires

Bioabsorbable Composite Laminates of Poly‐Lactic Acid Reinforced with Surface‐Modified Mg Wires for Orthopedic Implant Applications

Contact Info

Product

Resources

About