Study of endogenous hormones in endometrial cancer patients of premenopausal women

Abstract

Introduction: Several studies were conducted worldwide to estimate various endogenous hormone levels in endometrial cancer patients of post-menopausal women and very few studies were done in premenopausal women. In India, our study is the first study conducted to estimate the endogenous hormones in endometrial cancer patients of premenopausal age group. Materials and Methods: 25 number of endometrial cancer patients were taken as cases and 50 number of age matched healthy subjects were selected as controls for this study. Total testosterone, follicular estrogen, mid luteal estrogen, luteal estrogen, and follicular progesterone, mid luteal progesterone, luteal progesterone and fasting insulin were estimated for all the subjects. Results: Statistical significant increase were observed in the levels of testosterone, follicular progesterone, mid luteal progesterone and luteal progesterone in cases when compared to controls. No statistical significant difference were observed in follicular estrogen, mid luteal estrogen, luteal estrogen and fasting insulin levels between cases and controls. Conclusion: From our study we conclude that endogenous hormones play a major role in the development of endometrial cancer in pre menopausal women as Testosterone is increased and progesterone is decreased in cases when compared to controls. Extensive studies are required to diagnose endometrial cancer in early stages for better prognosis.