STUDY OF ENCAPSULATION OF SILICONE RUBBER IMPLANTS IN ANIMALS A Foreign-Body Reaction

Vistnes, Lars M.; Ksander, George A.; Kosek, Jon C.

doi:10.1097/00006534-197810000-00015

Cited by 92 publications

(29 citation statements)

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“…Additional studies with more detailed observations would be necessary to identify all important changes. With in vivo silicone implantation, postoperative formation of a fibrous connective tissue capsule around the silicone implant is inevitable [3,13,30,32]. Essentially, the formation of this capsule is one of the body's defense mechanisms to completely isolate foreign bodies [7,9,[30][31][32].…”

Section: Discussionmentioning

confidence: 99%

“…With in vivo silicone implantation, postoperative formation of a fibrous connective tissue capsule around the silicone implant is inevitable [3,13,30,32]. Essentially, the formation of this capsule is one of the body's defense mechanisms to completely isolate foreign bodies [7,9,[30][31][32]. Vistnes et al [30] reported that in the acute stage of the initial inflammatory response, if phagocytes failed to remove large implants as a silicone sheet, collagenous fibers would infiltrate and be arranged directly around the implant to form a fibrous tissue capsule isolating the foreign body.…”

Section: Discussionmentioning

confidence: 99%

“…Essentially, the formation of this capsule is one of the body's defense mechanisms to completely isolate foreign bodies [7,9,[30][31][32]. Vistnes et al [30] reported that in the acute stage of the initial inflammatory response, if phagocytes failed to remove large implants as a silicone sheet, collagenous fibers would infiltrate and be arranged directly around the implant to form a fibrous tissue capsule isolating the foreign body. A capsule eventually developed with fibrous layers and vascularity.…”

Section: Discussionmentioning

confidence: 99%

“…During the entire chronic stage, acid mucopolysaccharides were associated predominantly with the collagenous fibers. The foreign body reaction process that produces the fibrous capsule continues as long as the implant is present but disappears when the silicone sheet is completely removed [30][31][32]. Formation and development of this fibrous capsule are influenced by several factors such as properties of the silicone implant [7,30], local surgical trauma [9,14,30], postoperative formation of seroma or hematoma [30], and bleeding from local small vessels [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…Based on the similarity between animals and humans, and the fact the local foreign body reaction is essentially the same in all mammalian hosts [30], it is important to carefully consider the surgical designs and operative techniques involved in simultaneously using silicone implants and microvascular procedures to avoid direct contact between silicone implants and the microanastomosis.…”

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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e-PTFE as scleral buckling episcleral implants: An experimental and histopathologic study

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et al. 1999

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To investigate the effects of focal implantation of expanded polytetrafluoroethylene (e-PTFE) episcleral implants (i.e., explants or exoplants) on surrounding ocular tissues, an experimental and histopathological study was performed. Twenty-seven Fauve de Bourgogne rabbits eyes were implanted for a period of 3-11 months with oval-shaped e-PTFE episcleral implants. A newly formed capsule constantly encased the implants. Affected by the only two severe complications observed, 2 eyes had an endocapsular acute inflammation and could not be included in the study. Finally, 25 eyes were studied histopathologically. Neither intrusion nor extrusion of episcleral implants was observed. Other changes were related to implant characteristics. The inner surface of the capsule was often covered with numerous giant cells attesting to a foreign-body granuloma developed against the irregular outline of the episcleral implants. The porosity of the material was closely related to its surface irregularity, and also allowed its colonization by a fibrovascular and inflammatory tissue mainly in its peripheral layers. Under episcleral implants, sclera was both thinned and invaginated. Expanded PTFE hydrophobia was the other factor that might have suscitated granuloma. These microscopic changes are in contrast with an overall good apparent experimental tolerance to the material. However, additional studies on the long term behavior of this material would be helpful.

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Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats

Ravin

Olbrich

Levin

et al. 2001

J. Biomed. Mater. Res.

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Fibrous capsule formation around implants can inhibit solute exchange between implantable devices and the circulation. Parylene-n coated polycarbonate disks surrounded with growth factor reduced Matrigel (MG) or several gelatin-based matrices were implanted intramuscularly into rats for 21 or 50 days. MG supplemented with vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF) increased capsule microvascular density at 21 days (p < 0.05) when compared to bare parylene-coated polycarbonate disks (control). The increased microvascular density around VEGF- and bFGF-treated implants regressed by 50 days and was no longer significantly different from controls. The microvascular density induced by the gelatin-based matrices was not significantly different from controls at 21 days, but was increased at 50 days (p < 0.05), suggesting a slower, long-term effect. Disks treated with MG and gelatin-based matrices had thinner capsules at 21 days (p < 0.05). By 50 days, the capsule thicknesses around these implants were no longer statistically thinner than controls. The capsule thickness around implants treated with VEGF, bFGF, and essential gelatin-based matrix was thinner than controls at 50 days (p < 0.05). These results indicate that it is possible to increase functional microvascular density within fibrous capsules using angiogenic growth factors and gelatin-based matrices. However, this effect may be short-lived, requiring chronic administration of growth factors.

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STUDY OF ENCAPSULATION OF SILICONE RUBBER IMPLANTS IN ANIMALS A Foreign-Body Reaction

Cited by 92 publications

References 0 publications

Influence of Silicone Sheets on Microvascular Anastomosis

Influence of Silicone Sheets on Microvascular Anastomosis

e-PTFE as scleral buckling episcleral implants: An experimental and histopathologic study

Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats

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