Study of Electrophysiological Changes in Sensory Nerves Among Diabetic Smokers

Abdolzadeh, Ahmad; Moinuddin, Arsalan; Ahsan, Akif; Goel, Ashish

doi:10.7860/jcdr/2016/16673.7103

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…These discrepancies could be the result of the poor sensitivity of common methods of neuropathy testing [73, 74]. Of interest, Ahmad and colleagues [75], by using more sensitive and specific nerve conduction studies, were able to show that smoking was an independent risk factor for manifestations of neuropathy in patients with T2DM, with heavy smokers exhibiting worse nerve conduction.…”

Section: Smoking and Vascular Complicationsmentioning

confidence: 99%

Smoking and diabetes: dangerous liaisons and confusing relationships

Campagna

Alamo

Pino

et al. 2019

Diabetol Metab Syndr

138

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The combined harmful effects of cigarette smoking and hyperglycemia can accelerate vascular damage in patients with diabetes who smoke, as is well known. Can smoking cause diabetes? What are the effects of smoking on macro and microvascular complications? Now growing evidence indicates that regular smokers are at risk of developing incident diabetes. Since the prevalence rates of smoking in patients with diabetes are relatively similar to those of the general population, it is essential to address the main modifiable risk factor of smoking to prevent the onset of diabetes and delay the development of its complications. Quitting smoking shows clear benefits in terms of reducing or slowing the risk of cardiovascular morbidity and mortality in people with diabetes. Does quitting smoking decrease the incidence of diabetes and its progression? What are the effects of quitting smoking on complications? The current evidence does not seem to unequivocally suggest a positive role for quitting in patients with diabetes. Quitting smoking has also been shown to have a negative impact on body weight, glycemic control and subsequent increased risk of new-onset diabetes. Moreover, its role on microvascular complications of the disease is unclear. What are the current smoking cessation treatments, and which ones are better for patients with diabetes? Stopping smoking may be of value for diabetes prevention and management of the disease and its macrovascular and microvascular complications. Unfortunately, achieving long-lasting abstinence is not easy and novel approaches for managing these patients are needed. This narrative review examines the evidence on the impact of smoking and smoking cessation in patients with diabetes and particularly in type 2 diabetes mellitus and its complications. In addition, management options and potential future directions will be discussed.

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Section: Smoking and Vascular Complicationsmentioning

confidence: 99%

Smoking and diabetes: dangerous liaisons and confusing relationships

Campagna

Alamo

Pino

et al. 2019

Diabetol Metab Syndr

138

View full text Add to dashboard Cite

show abstract

“…In T2DM patients, smoking may also be a risk factor (58); in a recent study smoking was an independent risk factor, as heavy smokers exhibited worse nerve conduction studies (59). Likewise, smoking was also significantly associated with DPN in T1DM (40, 60), or exhibited a trend for association (20).…”

Section: Other Potential Risk Factors For Dpnmentioning

confidence: 99%

Mediators of diabetic neuropathy: is hyperglycemia the only culprit?

Grisold

Callaghan

Feldman

2017

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of this review Diabetic peripheral neuropathy (DPN) is a disabling, highly prevalent complication of both type 1 and type 2 diabetes mellitus (T1DM, T2DM). Large clinical studies support the concept that, in addition to hyperglycemia, components of the metabolic syndrome (MetS) may underlie the pathogenesis of DPN, especially in T2DM. This review will present the evidence supporting the MetS and its individual components as potential causal factors for the development of neuropathy. Recent findings In addition to poor glycemic control and duration of diabetes, components of MetS such as dyslipidemia, obesity, and hypertension, may have an important impact on the prevalence of DPN. Obesity and prediabetes have the most data to support their role in neuropathy, whereas hypertension and dyslipidemia have more mixed results. Non-metabolic factors, such as genetic susceptibility, age, height, gender, smoking, and alcohol, have also been highlighted as potential risk factors in peripheral neuropathy, although the exact contribution of these factors to DPN remains unknown. Summary DPN is a chronic and disabling disease, and the accurate identification and modification of DPN risk factors is important for clinical management. Recent data support a role for components of the MetS and other risk factors in the development of DPN, offering novel targets beyond hyperglycemia for therapeutic development.

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“…In line with the previous studies, this study shows that smoking increases the risk of UNE 10 – 12 . Smoking might decrease blood flow and induce changes in the myelin sheath leading to demyelination 31 , 32 . Smoking causes endothelial dysfunction and increases the production of free radicals, and may worsen the damage caused to peripheral nerves by ischemia 33 .…”

Section: Discussionmentioning

confidence: 99%

Work-related risk factors for ulnar nerve entrapment in the Northern Finland Birth Cohort of 1966

Miettinen

Ryhänen

Shiri

et al. 2021

Sci Rep

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Ulnar nerve entrapment (UNE) is the second most common entrapment neuropathy in the upper extremity. The aetiology of UNE is multifactorial and is still not fully understood. The aim of the study was to identify occupational risk factors for UNE and to determine whether smoking modifies the effects of work-related factors on UNE. The study population consisted of the Northern Finland Birth Cohort of 1966 (NFBC1966). In total, 6325 individuals active in working life participated at baseline in 1997. Occupational risk factors were evaluated by a questionnaire at baseline. The data on hospitalizations due to UNE were obtained from the Care Register for Health Care between 1997 and 2018. The incidence rate of hospitalization due to UNE was 47.6 cases per 100,000 person-years. After adjusting for confounders, entrepreneurs (Hazard ratio (HR) = 3.68, 95% CI 1.20–11.27), smokers (HR = 2.51, 95% CI 1.43–4.41), workers exposed to temperature changes (HR = 1.72, 95% CI 1.00–2.93), workers with physically demanding jobs (HR = 3.02, 95% CI 1.39–6.58), and workers exposed to hand vibration (HR = 1.94, 95% CI 1.00–3.77) were at an increased risk of hospitalization for UNE. Exposure to work requiring arm elevation increased the risk of hospitalization due to UNE among smokers (HR = 2.62, 95% CI 1.13–6.07), but not among non-smokers. Work-related exposure to vibration and temperature changes, and physically demanding work increase the risk of hospitalization for UNE. Smoking may potentiate the adverse effects of work-related factors on UNE.

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Study of Electrophysiological Changes in Sensory Nerves Among Diabetic Smokers

Abstract: Present study indicates that nerves of lower limbs are more susceptible to diabetic assault as compared to upper limb suggesting that long nerves are commonly affected. Also, apart from duration and severity of diabetes, smoking itself is an independent factor for diabetic neuropathy.

Cited by 6 publications

References 13 publications

Smoking and diabetes: dangerous liaisons and confusing relationships

Smoking and diabetes: dangerous liaisons and confusing relationships

Mediators of diabetic neuropathy: is hyperglycemia the only culprit?

Work-related risk factors for ulnar nerve entrapment in the Northern Finland Birth Cohort of 1966

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