Study of Effects of Photodynamic Therapy (PDT), in Scar-Induced Skin Wounds in Rats Wistar: The New Clinical Perspective for Ulcers

Pinto, Marcus Viní­cius de Mello; Sampaio, Aline Ronis; Gonçalves, Reggiani Vilela; Veiga, Carlos Eduardo Tenório da; Rocha, Lamara Laguardia Valente; Costa, Daniel; Lopes, Lina Claudia Pereira; Ferreira, Rafael Batista; Valim, Pamela Mara Cainelli; Chaveiro, Kellen Regina Rodrigues; Sathler, Elias Sobreira; Vieira, Richard Raphael Borges Tavares; Bernardes, Isabela Nardoni

doi:10.4236/mri.2017.61001

Cited by 6 publications

(7 citation statements)

References 12 publications

(17 reference statements)

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“…We hope this study contributes beyond the reflection on concepts and theories on laser [4] [7]. It is extremely important to stir in future researchers the interest in a topic as complex and important for humanity [8].…”

Section: Introductionmentioning

confidence: 92%

“…This invention was based on a variety of ideas and facts that originated in different branches of Physics and Engineering, but mainly in phenomena of Atomic and Molecular Physics Journal of Biosciences and Medicines that can not be explained by Classical Physics. It was the application of Einstein's Quantum Mechanics to Electronics which allowed the blossoming of what we call Quantum Electronics, a field that has developed after World War II and which led to the discovery of many devices, starting with the transistor in the '40s, culminating in the discovery of the laser in the '60s [8].…”

Section: A Little Bit Of Historymentioning

confidence: 99%

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A Study of Laser Effectiveness in Injured Tissues Regeneration

Pinto¹,

Sampaio²,

Baron³

et al. 2021

JBM

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This study aimed to understand the use of low level laser in the regeneration of injured tissues. Also to design our own opinion on the subject, as chemists. Laser is nothing more than a light with very special characteristics that grant it therapeutic properties. We can observe the existence of three different types of laser, being one of them the therapeutic laser, which is used in substitution for medications or along with them. Another type of laser is the surgical one and, in addition to these, there is a diagnostic type. A great advantage is that, instead of taking the medicine, the patient's own body can be activated by the laser to produce certain substances that can often replace the drugs. This is a literature review emphasizing the use of low level laser. Thus, the reflections from this study can contribute to the amplification of the production of knowledge that aims at the resignification of the use of laser in therapy. Greater attention was given to two types of laser radiation: He-Ne

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Section: Introductionmentioning

confidence: 92%

Section: A Little Bit Of Historymentioning

confidence: 99%

A Study of Laser Effectiveness in Injured Tissues Regeneration

Pinto¹,

Sampaio²,

Baron³

et al. 2021

JBM

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“…Several authors describe the laser as an advanced healing tool that accelerates and optimizes the tissue repair process [8] [9]. Increased synthesis of RNA, DNA and adenosine triphosphate (ATP) is considered when the laser is used in the tissue repairment process [10] [11].…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy in the Healing of the Areolo-Papillary Complex after Mastectomy—Case Report

Marquetti¹,

Pinto²,

Ronis³

et al. 2018

Health

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Some breast reconstruction surgeries after mastectomy, or even reductive mammoplasty, may evolve unexpectedly when the areolopapillary complex heals and develop dehiscences, necrosis and delayed healing. The purpose of this case report was to verify the efficacy of photodynamic therapy in wound healing of the areolopapillary complex. This was a case report of a female patient with diabetes, fibromyalgia and diagnosed with breast cancer, with necrotic areolopapillary complex, after debridement, photodynamic therapy started with clobetasol propionate associated with methylene blue and low power laser application. At the beginning of the treatment with photodynamic therapy, the wound had 6 centimeters of diameter, and after 19 sessions, the wound was closed completely with normalization of the color of the nipple. The photodynamic therapy is advancing a lot in healing of infected wounds and complex wounds. It can be said that in this case report, photodynamic therapy was fundamental for the complete healing, being considered a promising treatment and another alternative for dermatofunctional physiotherapists.

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“…1−4 In PDT, a photosensitizer (PS), upon light irradiation, produces reactive oxygen species (ROS) that damage proteins, DNA, or lipids inside cells to induce apoptosis. 5 Although, traditionally, porphyrin-based photosensitizers have been used for clinical purposes, their intrinsic hydrophobicity, ambiguity in the intersystem crossing (ISC) mechanism, and synthetic difficulty are major concerns. 6 As an alternative approach, heavy-atomcontaining organic molecules have been explored in the recent past, where the presence of the heavy atom enhances the spin− orbit coupling and thus facilitates ISC.…”

mentioning

confidence: 99%

Redox-Triggered Activation of Heavy-Atom-Free Photosensitizer and Implications in Targeted Photodynamic Therapy

et al. 2023

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A strategy for a redox-activatable heavy-atom-free photosensitizer (PS) based on thiolated naphthalimide has been demonstrated. The PS exhibits excellent reactive oxygen species (ROS) generation in the monomeric state. However, when encapsulated in a disulfide containing bioreducible amphiphilic triblock copolymer aggregate (polymersome), the PS exhibits aggregation in the confined hydrophobic environment, which results in a smaller exciton exchange rate between the singlet and triplet excited states (TDDFT studies), and consequently, the ROS generation ability of the PS was almost fully diminished. Such a PS (in the dormant state)-loaded redox-responsive polymersome showed excellent cellular uptake and intracellular release of the PS in its active form, which enabled cell killing upon light irradiation due to ROS generation. In a control experiment involving aggregates of a similar block copolymer, but lacking the bioreducible disulfide linkage, no intracellular reactivation of the PS was noticed, highlighting the importance of stimuli-responsive polymer assemblies in the area of targeted photodynamic therapy.

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Study of Effects of Photodynamic Therapy (PDT), in Scar-Induced Skin Wounds in Rats Wistar: The New Clinical Perspective for Ulcers

Cited by 6 publications

References 12 publications

A Study of Laser Effectiveness in Injured Tissues Regeneration

A Study of Laser Effectiveness in Injured Tissues Regeneration

Photodynamic Therapy in the Healing of the Areolo-Papillary Complex after Mastectomy—Case Report

Redox-Triggered Activation of Heavy-Atom-Free Photosensitizer and Implications in Targeted Photodynamic Therapy

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