Study of Effects of Low Doses UV Radiation on Microporous Polysulfone Membranes in Sterilization Process

Suyanto, Hery; Sumadiyasa, Made; Wendri, Nyoman

doi:10.4236/ojopm.2013.31003

Cited by 28 publications

(14 citation statements)

References 13 publications

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“…24 It has strong antimicrobial activity, but its ability to penetrate in solid matter is very poor and affects polymer molecular weight, chain length, polydispersity, branching, and chain termination. 25,26 Considering that each sterilization method has its advantages and limitations, the choice of a suitable process should be carefully studied according to the device features and final application. Further, the development of new processing technologies and the ability to control polymer structure and morphology at micro and nanoscale dimension arises new problems, especially if fiber alignment is one of the main features of the polymer membranes.…”

Section: Introductionmentioning

confidence: 99%

Effect of Sterilization Methods on Electrospun Poly(lactic acid) (PLA) Fiber Alignment for Biomedical Applications

Valente

Silva

Gomes

et al. 2016

ACS Appl. Mater. Interfaces

180

122

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Medically approved sterility methods should be a major concern when developing a polymeric scaffold, mainly when commercialization is envisaged. In the present work, poly(lactic acid) (PLA) fiber membranes were processed by electrospinning with random and aligned fiber alignment and sterilized under UV, ethylene oxide (EO), and γ-radiation, the most common ones for clinical applications. It was observed that UV light and γ-radiation do not influence fiber morphology or alignment, while electrospun samples treated with EO lead to fiber orientation loss and morphology changing from cylindrical fibers to ribbon-like structures, accompanied to an increase of polymer crystallinity up to 28%. UV light and γ-radiation sterilization methods showed to be less harmful to polymer morphology, without significant changes in polymer thermal and mechanical properties, but a slight increase of polymer wettability was detected, especially for the samples treated with UV radiation. In vitro results indicate that both UV and γ-radiation treatments of PLA membranes allow the adhesion and proliferation of MG 63 osteoblastic cells in a close interaction with the fiber meshes and with a growth pattern highly sensitive to the underlying random or aligned fiber orientation. These results are suggestive of the potential of both γ-radiation sterilized PLA membranes for clinical applications in regenerative medicine, especially those where customized membrane morphology and fiber alignment is an important issue. AbstractMedical approved sterility methods should be a major concern when developing a polymeric scaffold, mainly when commercialization is envisaged. In the present work, PLA fibre membranes were processed by electrospinning with random and aligned fibre alignment and sterilized under UV, ethylene oxide (EO) and -radiation, the most common ones for clinical applications. It was observed that UV light and -radiation does not influence fibre morphology or alignment, while electrospun samples treated with EO lead to fibre orientation loss and morphology changing from cylindrical fibres to ribbon like structures, accompanied to an increase of polymer crystallinity up to 28%.UV light and -radiation sterilization methods showed to be less harmful to polymer morphology, without significant changes in polymer thermal and mechanical properties, but a slight increase of polymer wettability was detected, especially for the samples treated with UV radiation. In vitro results indicate that both UV and -radiation treatments of PLA membranes allow the adhesion and proliferation of MG 63 osteoblastic cells in a close interaction with the fibre meshes, and with a growth pattern highly sensitive to the underlying random or aligned fibre orientation. These results are suggestive of the potential of both -radiation sterilized PLA membranes for clinical applications in regenerative medicine, especially those where customized membrane morphology and fibre alignment is an important issue.

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Section: Introductionmentioning

confidence: 99%

Effect of Sterilization Methods on Electrospun Poly(lactic acid) (PLA) Fiber Alignment for Biomedical Applications

Valente

Silva

Gomes

et al. 2016

ACS Appl. Mater. Interfaces

180

122

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“…The characteristic peak around 3,200 to 3,550 cm −1 is assigned to hydroxyl stretching vibration, and the main ones in the range of 2,950–2,850 cm −1 are attributed to –C‐H stretching vibration. The wavenumbers around 1,350–1,550 cm −1 are associated with –SO 4 −2 and those observed in the range of 1,100 to 1,200 cm −1 are related to –C‐O stretching (Dehghani Kiadehi, Rahimpour, Jahanshahi, & Ghoreyshi, 2015; Rupiasih, Suyanto, Sumadiyasa, & Wendri, 2013). In the FT‐IR spectrum of PSF/TR‐100 membrane, the characteristic peaks at 600–3500 cm −1 remain unchanged with the incorporation of surfactant, demonstrating that the structure of PSF was well preserved.…”

Section: Resultsmentioning

confidence: 99%

Electrospun hydrophobe nanofibrous membrane based on polysulfone/Triton x‐100: A novel vehicle to concentrate pomegranate juice

Najafi

Emam‐Djomeh

Askari

et al. 2020

J Food Process Engineering

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Aims: The present work aimed to fabricate an electrospun hydrophobe nanofibrous membrane based on polysulfone (PSF) to concentrate pomegranate juice, and evaluate the effect of Triton x-100 (TR-100) on the physicochemical properties of the fabricated membrane. Methods: Morphological properties, surface hydrophobicity, and mechanical performance of the nanofibrous membrane were evaluated, and then, its ability to concentrate pomegranate juice was tested.

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“…Studies have confirmed that the microstructure and the performance of PSF are affected by ultraviolet irradiation within a very short time of exposure, leading to simultaneous chain scission and crosslinking [16]. PSF photooxidation in an oxygen atmosphere leads to an oxidized surface with an increase in the relative amount of sulphur on the surface.…”

Section: Introductionmentioning

confidence: 90%

Polysulfone/Cellulose Acetate Butyrate Environmentally Friendly Blend to minimize the Impact of UV Radiation

Rm¹,

Za²,

Na³

et al. 2015

J Material Sci Eng

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An eco-friendly transparent blend for ultraviolet and visible light rays from polysulfone (PSF) and cellulose acetate butyrate (CAB) was prepared by melting and re-molding. Some optical, mechanical, thermal and morphological properties of the blend were studied by means of UV-Vis spectroscopy, dynamic mechanical analysis (DMA), thermogravimetric analysis (TGA), scanning electron microscope (SEM) and X-ray diffraction (XRD). The UV-Vis spectroscopy results showed that the blend became more transparent in the ultraviolet region with an increase in CAB concentration, especially at the damage threshold (268 nm). The preferable blend sample contained 0.2% w/w CAB in the PSF/CAB blend, signifying low ultraviolet light absorption while preserving the transparency of the blend. The results also demonstrated that the amount of 0.2% CAB in PSF increased the modulus and thermal stability while decreasing the value of the glass transition temperature.

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Study of Effects of Low Doses UV Radiation on Microporous Polysulfone Membranes in Sterilization Process

Cited by 28 publications

References 13 publications

Effect of Sterilization Methods on Electrospun Poly(lactic acid) (PLA) Fiber Alignment for Biomedical Applications

Effect of Sterilization Methods on Electrospun Poly(lactic acid) (PLA) Fiber Alignment for Biomedical Applications

Electrospun hydrophobe nanofibrous membrane based on polysulfone/Triton x‐100: A novel vehicle to concentrate pomegranate juice

Polysulfone/Cellulose Acetate Butyrate Environmentally Friendly Blend to minimize the Impact of UV Radiation

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