Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians

Abstract

Background: A cluster of many risk factors for type 2 diabetes and cardiovascular disease is used to describe the metabolic syndrome (MetS). Moreover, genetic differences associated with metabolic syndrome play a key role in its prevalence and side effects. This study aims to investigate the expression of DYRK1B and its association with metabolic syndrome in a small cohort of Egyptian.Materials and methods: A total of 100 adult Egyptians (50 with MetS and 50 healthy control subjects) were included to this study. Clinical, biochemical and anthropometric analysis were assessed. Relative gene expressions of DYRK1B were compared between two groups of subjects using real time PCR.Results: We observed marked overexpression in DYRK1B (p<0.05) in MetS subjects when compared with the healthy control subjects.Conclusion: This is the rst study to provide evidence that DYRK1B is highly expressed among the MetS subjects.

Drug targets regulate systemic metabolism and provide new horizons to treat nonalcoholic steatohepatitis

“…The kinase Dyrk1b is upregulated in patients with metabolic syndrome in Egyptian cohort [ 172 ]. Besides its key function in ribosomal DNA double-strand breaks repair, Dyrk1b activates mTORC2 and promotes lipogenesis in a kinase-independent way (Section 3.4 ) [ 173 ].…”