Study of dose-response and radical decay curves of gamma irradiated norfloxacin using EPR spectroscopy

Abstract

In this study, Electron Paramagnetic Resonance (EPR) spectra of unirradiated and γ-irradiated at doses of 1, 5, 10, 12 and 15 kGy norfloxacin (NOF) were investigated. Before irradiation no EPR signal were observed. After irradiation a weak singlet signal at g = 2.0039 were obtained at room temperature. In order to describe the variation of EPR signal intensity with absorbed radiation dose, several mathematical equations were tried. Increasing irradiation dose up to 15 kGy has increased the signal intensity of the central signal however, no significant changes were observed in g spectroscopic splitting factor. The stability of signal intensity of irradiated NOF was studied over a storage period of 200 days. According to analyses conducted, EPR spectroscopy can be used to distinguish irradiated and unirradiated samples from each other.

Investigation of radiosensitivity of gamma irradiated procaine hydrochloride in the solid state

“…Several mathematical functions were tried to describe evolution of the central EPR signal with absorbed radiation dose. Linear, exponential and polynomial functions are frequently used for this purpose [17][18][19]. Mathematical equations that show the best fit of the samples and correlation coefficient (R 2 ) are given in Table 2.…”