Study of different types of hydroxypropyl celluloses (HPC) based on terahertz time-domain spectroscopy (THz-TDS)

Abstract

Differences in hydroxypropyl cellulose (HPC) include the degree of hydroxypropyl substitution of cellulose or the molecular weight of hydroxypropyl cellulose. The differences have an impact not only on its physicochemical properties but also on the drug delivery process. It is sensitive to a wide range of intermolecular vibrations as well as lattice phonons using Terahertz time-domain spectroscopy (THz-TDS). We have obtained the spectral parameters of various kinds of hydroxypropyl celluloses by THz-TDS measurement. The experimental results show that the spectral characteristics of various kinds of hydroxypropyl celluloses are distinguishable. Using THz-TDS, we can quickly and accurately distinguish different hydroxypropyl celluloses and analyze the physicochemical properties of different hydroxypropyl celluloses.