Study of Dickkopf-1 (DKK-1)  Gene Expression in Hepatocellular  Carcinoma Patients

Watany, Mona Mohamed

doi:10.7860/jcdr/2017/23095.9450

Cited by 27 publications

(11 citation statements)

References 28 publications

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“…Multiple attempts are ongoing to develop DKK1 as a non-invasive biomarker for tumorigenesis or metastasis (Begenik et al, 2014;Gomceli et al, 2012;Hall et al, 2008;Liu et al, 2017;Peng et al, 2016;Rachner et al, 2014;Watany et al, 2017). It has been suggested that DKK1 could play oncogenic roles in hepatocellular carcinoma and esophageal cancer, multiple myeloma and prostate cancer (Chen et al, 2013;Fulciniti et al, 2009;Makino et al, 2009;Rachner et al, 2014).…”

Section: Dkk1 Cancer and Pathological Inflammation 21 Dkk1 And Camentioning

confidence: 99%

Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation

Chae

Bothwell

2019

Differentiation

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The Wnt signaling pathway plays essential roles in tissue or organ homeostasis by regulating cell proliferation and differentiation. Upon tissue or organ injury, inflammation is coupled with tissue repair and regeneration process. The canonical Wnt signaling transduction pathway is crucial for cell proliferation, cell differentiation, and tissue regeneration. Dickkopf1 (DKK1) is a quintessential Wnt antagonist that inhibits the Wnt-mediated tissue repair process. Recent studies reported increased levels of DKK1 in many diseases such as cancer, infection, and musculoskeletal diseases. In many cases, the role of DKK1 has been identified as a pro-inflammatory ligand and the expression levels are associated with poor disease outcomes. A variety of cell types including platelets, endothelial cells, and cancer cells secrete DKK1 upon stimuli. This puts DKK1 in a unique place to view immune responses from multicellular interactions in tissue injury and repair process. In this review, we discuss recent efforts to address the underlying mechanism regarding the pro-inflammatory role of DKK1 in cancer, bone diseases, and other inflammatory diseases.

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Section: Dkk1 Cancer and Pathological Inflammation 21 Dkk1 And Camentioning

confidence: 99%

Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation

Chae

Bothwell

2019

Differentiation

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“…Liver cancer (HCC) ranks as the fifth most prevalent cancer worldwide, and is ranked third as a common cause of death due to cancer [1,2]. In Egypt, the prevalence of hepatocellular carcinoma increased markedly in the last decade due to the high prevalence of hepatitis C virus and the improved survival for cirrhotic patients allowing time for some of them to develop HCC [3][4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patients

Ebrahim

Shehata

Abou-Saif

et al. 2020

Egypt J Radiol Nucl Med

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Background: Liver cancer (HCC) ranks as the fifth most prevalent cancer worldwide and is ranked third as a common cause of death due to cancer. The benefit of Fibroscan in assessing the risk of developing liver cancer that was evaluated in this work was not fully demonstrated. The aim of this work was to study the role and clinical significance of Fibroscan for early detection of liver cancer in hepatitis C patients with cirrhosis. Results: As regards binary logistic regression for predictors of HCC, it was found that Child C, AST, Fibroscan, and AFP were predictors for developing HCC. Liver stiffness values were significantly high in all groups, and the specific cutoff value for hepatocellular carcinoma detection was above 24 kPa in hepatitis C virus patients. Therefore, liver stiffness of more than 24 kPa can be considered as an independent risk factor for the development of liver cancer in HCV patients. Conclusion: Liver stiffness of more than 24 kPa was an independent risk factor for developing new liver cancer in HCV patients.

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“…Second, prognostic indicators of HCC and PC were relatively small, mainly due to the rapid development of HCC and PC, and few prognostic data can be provided. Moreover, there was a large difference between HCC and PC in the prognosis data from the included studies, so the data that can evaluate the prognosis indicators had clinical heterogeneity 68 ; therefore, there may be no significant differences in the HCC group in our study. However, there are also data suggesting the role of DKK-1 overexpression in HCC development, which was consistent with the results provided by our predictive and diagnostic data.…”

Section: Discussionmentioning

confidence: 81%

Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis

Jiang¹,

Hui²,

Qin³

et al. 2020

J. Cancer

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Objective: To evaluate the diagnosis accuracy and prognostic significance of bio-marker dickkopf-1(DKK-1) protein in GIC, and also sub-type of hepatocellular carcinoma (HCC), pancreas carcinomas (PC), oesophageal carcinoma (EPC) and Adenocarcinoma of esophago-gastric junction (AEGJ), etc. Methods: Electronic databases were searched from inception to May 2020. Patients were diagnosed with gastrointestinal carcinomas, and provided data on the correlation between high and low DKK-1 expression and diagnosis or prognosis. Results: Forty-three publications involving 9318 participants were included in the network meta-analysis, with 31 of them providing data for diagnosis value and 18 records were eligible for providing prognosis value of DKK-1. DKK-1 has a moderate diagnostic value for overall GIC, HCC and PC. In addition, for the combined diagnosis value of DKK-1 +AFP, high diagnostic accuracy value could be determined in HCC and early HCC group, respectively. Whereas, diagnosis efficiency of DKK-1+CA19-9 was also better than that of DKK-1 alone with AUC value is above 0.95. For the prognosis meta-analysis of histopathological stratification, we found that EPC and AEGJ ranked the best for the histopathological stratification of prognosis from network meta-analysis. This systematic review protocol was registered with the PROSPERO registry (No.CRD42020167910). Conclusion: DKK-1 has good diagnostic accuracy, especially combination of DKK-1+AFP in HCC and DKK-1+CA19-9 in PC, whereas modest prognostic significant in GIC. Future head-to-head researches are warranted for DKK-1 expression in HCC and PC tissue.

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Study of Dickkopf-1 (DKK-1) Gene Expression in Hepatocellular Carcinoma Patients

Cited by 27 publications

References 28 publications

Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation

Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation

Role of Fibroscan for early detection of hepatocellular carcinoma (HCC) in hepatitis C cirrhotic patients

Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis

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