Study of cytotoxic activity of Ti–13Nb–13Zr medical alloy with different surface finishing techniques

Abstract

The characterization of materials surface is essential, as the initial in vivo response is highly dependent on surface properties. Surface topography is a key aspect that influences the response of cells to products resulting from interaction with the surface of a titanium alloy, including parameters such as adhesion, spread, migration, proliferation, and differentiation of cells. Various surface modifications are used to improve the interface properties between MC3T3 and NHDF cells and the Ti–13Nb–13Zr-based surface. Among the techniques discussed in this paper, scanning electron microscopy, laser confocal scanning microscopy, and computed tomography are adequate to investigate materials topography at different scale levels. Chemical characterization of the outer layers of Ti–13Nb–13Zr samples was performed with X-ray photoelectron spectrometry. Studies have shown that the surfaces resulting from the treatment enabling the formation of titanium oxide and zirconium oxide show the lowest cytotoxicity. Implants made from the new generation of titanium alloy, not containing toxic elements, with the use of surface modification could be an essential innovation in implantology.

Biocompatibility and Corrosion of Microplasma-Sprayed Titanium and Tantalum Coatings versus Titanium Alloy

“…Al 2 O 3 particles could be recognized on the surface, some of which are embedded into the substrate. Al element has a controversial influence on health, but some groups report that biocompatibility could decrease with an increase in Al content [48], and aluminum could cause Alzheimer's disease [49]. Both coatings have a rough and irregular surface with uniformly distributed pores and partially/completely melted particles.…”