Study of cross-linking of gelatin by ethylene glycol diglycidyl ether

Vargas‐Gutiérrez, G.; Acevedo, J.L.; López, J Ortiz; Romero‐García, Jorge

doi:10.1016/j.matlet.2008.04.020

Cited by 55 publications

(45 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The uncrosslinked samples were not evaluated due to their high dissolvability in aqueous medium. The capability to absorb water is known to decrease with the increase of crosslinking degree as the polymer chains become closer due the new bond formation, making the mesh more dense, with higher retraction forces [39,46]. This trend was also observed in this work, using gelatin crosslinked with BDDGE (4 and 6% v/v) for different reaction times.…”

Section: Water Uptake Swelling Dissolvability and Water Vapor Permesupporting

confidence: 77%

In situ crosslinked electrospun gelatin nanofibers for skin regeneration

Dias

Baptista-Silva

Oliveíra

et al. 2017

European Polymer Journal

View full text Add to dashboard Cite

Due to its intrinsic similarity to the extracellular matrix, gelatin electrospun nanofibrous meshes are promising scaffold structures for wound dressings and tissue engineering applications. However, gelatin is water soluble and presents poor mechanical properties, which generally constitute relevant limitations to its applicability. In this work, gelatin was in situ crosslinked with 1,4-butanediol diglycidyl ether (BDDGE) at different concentrations (2, 4 and 6 wt-%) and incubation time-points (24, 48 and 72h) at 37ºC. The physico-chemical and biological properties of BDDGEcrosslinked electrospun gelatin meshes were investigated. Results show that by changing the BDDGE concentration it is possible to produce nanofibers crosslinked in situ with well-defined morphology and modulate fiber size and mechanical properties. Crosslinked gelatin meshes show no toxicity towards fibroblasts, stimulating their adhesion, proliferation and synthesis of new extracellular matrix, thereby indicating the potential of this strategy for skin tissue engineering.

show abstract

Section: Water Uptake Swelling Dissolvability and Water Vapor Permesupporting

confidence: 77%

In situ crosslinked electrospun gelatin nanofibers for skin regeneration

Dias

Baptista-Silva

Oliveíra

et al. 2017

European Polymer Journal

View full text Add to dashboard Cite

show abstract

“…Several components of polyepoxy family have been reported, between which ethylene glycol diglycidyl ether, with two epoxide functional groups located on both molecule´s ends, most reactive due to the high energy is associated to the considerable strains that exist within the three-membered ring. For these type of cross-linking agent, the opening of the epoxide ring happen simultaneously to the occurrence of the cross-linking reaction, which can occur within acidic and basic media (Vargas et al, 2008). (Mi, 2005).…”

Section: Methodsmentioning

confidence: 99%

Collagen- vs. Gelatine-Based Biomaterials and Their Biocompatibility: Review and Perspectives

Gorgieva¹,

Kokol²

2011

Biomaterials Applications for Nanomedicine

244

250

View full text Add to dashboard Cite

“…Graft and crosslinking copolymerization are well known methods for the modification of protein and represent convenient and effective ways for improving the physical and mechanical properties for practical uses. Various reagents have been used to modify protein, such as epoxy compounds,1–3 glutaraldehyde,4–6 diisocyanate,7–9 carbodiimide,10–13 and so on.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of gelatin‐polydimethylsiloxane graft copolymers

Zhang

et al. 2010

J of Applied Polymer Sci

View full text Add to dashboard Cite

Gelatin-polydimethylsiloxane (PDMS) graft copolymers were prepared through the reaction between gelatin and a-[3-(2,3-epoxypropoxy)propyl]-x-butyl-PDMSs. The copolymers were characterized by FTIR and 1 H-NMR spectra. As proved by wide angle X-ray analysis, a new characteristic crystalline peak appeared after the bonding of PDMS to gelatin chains. The microstructure and the elemental identification of gelatin and copolymers were followed through scanning electron microscope with energy dispersive spectrometer. The glass transition temperature of gelatin and copolymers were obtained by differential scanning calorimetry analysis.

show abstract

Study of cross-linking of gelatin by ethylene glycol diglycidyl ether

Cited by 55 publications

References 9 publications

In situ crosslinked electrospun gelatin nanofibers for skin regeneration

In situ crosslinked electrospun gelatin nanofibers for skin regeneration

Collagen- vs. Gelatine-Based Biomaterials and Their Biocompatibility: Review and Perspectives

Synthesis and characterization of gelatin‐polydimethylsiloxane graft copolymers

Contact Info

Product

Resources

About