Study of Croatian non-aromatic naphthalane constituents with skeletons analogous to bioactive compounds

Alajbeg, Ivan; Dinter, Gordan; Alajbeg, Anđa; Telen, Sanda; Prostenik, M. V.

doi:10.1016/s0021-9673(01)00720-8

Cited by 5 publications

(9 citation statements)

References 2 publications

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“…Besides the others, GC-MS study was focused onto steranes as potentially healing components [11][12][13][14][15]. In N1 there were identified prominent sterane peaks [16,17] belonging to cholestanes, ergostanes, and stigmastanes (by m /z 218 fragmentogram in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…The modern knowledge related to naphthalane suggests [11][12][13][14][15] the increase in steranes content because of its bioactivity as healing agents. Also, it is generally known that aromatics should be avoided since among them there are potentially dangerous carcinogenic ones; thus, modern pharmacopoeias (for example [21]) are rather cautious.…”

Section: Discussionmentioning

confidence: 99%

“…Today there is a solution offered and a new naphthalane version which has been proved [11][12][13][14][15] to satisfy both criteria, regarding high sterane concentration as well as completely avoiding aromatics, as well as to be bioactive. It is a nonaromatic version of naphthalane very rich in genuine geogenic steranes in the structure as native as in petroleum.…”

Section: Discussionmentioning

confidence: 99%

“…Namely, some recent studies of nonaromatic naphthalane (NAN), which is a noncolored transparent version of naphthalane, stressed the potential significance of steranes as the healing components in the related analytical [11][12][13], biomedical [14], and clinical [15] research. Since aromatic compounds are the expected constituents of brown naphthalanes, and since there are aromatics which should be taken with caution due to their potential carcinogenity, aromatics were studied for ring number and quantity.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Azerbaijani and Croatian brown naphthalane

Alajbeg¹,

Donelli²,

Alajbeg³

et al. 2005

J of Separation Science

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In spite of the fact that noncolored (nonaromatic) naphthalane containing high sterane content has been proved as bioactive and efficient in the treatment of psoriasis vulgaris, brown naphthalanes, which contain aromatics, are still in use. Thousands of patients, who have been passing through the therapy, deserve thorough and permanent study of brown naphthalanes. For that reason, two frequently used brown naphthalane preparations, one of the Azerbaijani (N1) and the other of the Croatian (N2) origin, were studied. The samples underwent the study by means of GC, OT LC, and normal-phase HPLC, as separation techniques. In addition, some bulk properties, elemental composition, and group composition by 1H NMR were determined. GC-MS served in compound types, especially in sterane detection. Both of the samples were found to be unresolved complex mixtures, relatively poor in n-alkanes. Isoalkanes, cycloalkanes, and aromatic compounds, in a great variety of isomers and homologs, made the majority of both of the samples. N1 was a dark, viscous, nontransparent fluid with a strong petroleum smell. Aromatics, which made 53% mass by OT LC and 54% mass by 1H NMR were found to be composed of mono-, di-, and tri+ -aromatic compounds. Tri+ -aromatic compounds were three to four times more abundant in N1 than in N2. Beside hydrocarbons, N1 comprised some organic compounds with polar functional groups. Also, some asphaltenes were found in it. N1 contained well-presented steranes, which are thought to be bioactive naphthalane ingredients. N2 was a pale brown liquid, with smell similar to gasoline. It contained somewhat lower percentage of aromatics (46% mass) and comparatively lower percentage of tri+ fused aromatics among which carcinogens might be expected. N2 was almost purely composed of hydrocarbons. It seemed to contain low content of steranes due to relatively low upper temperature of the distillation range applied in N2 preparation.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of Azerbaijani and Croatian brown naphthalane

Alajbeg¹,

Donelli²,

Alajbeg³

et al. 2005

J of Separation Science

Self Cite

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“…Geogenic steranes were indicated as potential bioactive agents influencing healing effects. [5][6][7][8][9][10][11][12] On the one hand, molecular skeletons of some potentially bioactive geogenic steranes were similar to D-vitamins, steroid hormones and corticosteroid drugs. 9 On the other hand, the research emphasized the problem associated with the presence of toxic polycyclic aromatic hydrocarbons (PAHs) which are common constituents of naphthalan oils 13,14 as well as of non-refined naphthalan preparations.…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Physical Properties of “Pale Yellow” Naphtalan

Alajbeg¹,

Brkić²,

Ahel³

et al. 2011

Croat. Chem. Acta

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Abstract. The Pale Yellow (PY) Naphthalan is potentially a new treatment modality for some oral mucosal and dermatological diseases. Its chemical composition and physical properties were studied by standard and sophisticated methods. Special attention was paid to steranes and hopanes as favorable components and to aromatics as unfavorable compounds. PY Naphthalan is predominantly composed of saturated aliphatic hydrocarbons of different structures, and of hydrocarbons comprising aromatic ring(s) (< 15%). Among aromatics, 98% were monoaromatics and 2% diaromatics, while 16 polycyclic aromatic hydrocarbons designated by US Environmental Protection Agency as priority pollutants were found at minimum detectability levels. Steranes and hopanes appeared in native geogenic clusters of homologs and each of identified compounds was in native geogenic configuration. Steranes were in the range from norcholestanes up to propyl cholestanes and hopanes up to pentakishomohopanes. The content of steranes and hopanes was relatively high. Compared to the other naphthalan products, the composition of PY Naphthalan is remarkably improved. Physical properties make PY Naphthalan convenient for application. (doi: 10.5562/cca1886)

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Naphthalan Oil in the Treatment of Psoriasis and Psoriatic Arthritis

Krnjević-Pezić¹,

Alajbeg

Maričić³

et al. 2012

Psoriasis Forum

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Background Naphthalan is a specific form of medicinal earth oil, and a number of subtypes are used in topical therapy for psoriasis and psoriatic arthritis. In the present study, yellow naphthalan oil that is enriched with steranes but that has a reduced content of polyaromatics was used. Objective The aim of the study was to assess the effect of naphthalan on psoriatic skin lesions, on painful and swollen joints, and on functional status of patients with psoriatic arthritis. Methods The study included 28 patients with chronic stationary psoriasis (psoriasis vulgaris) and 12 patients with psoriatic arthritis. Results In the psoriasis vulgaris study arm, the mean ± SD Psoriasis Area and Severity Index score was 23.1 ± 7.5 at baseline; it was 7.95 ± 4.08 after 3 weeks of naphthalan treatment. In the majority of patients, naphthalan treatment reduced articular pain and edema and improved mobility of affected joints. Conclusion Naphthalan provides efficacious therapy in the management of mild to moderate psoriasis and psoriatic arthritis.

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Study of Croatian non-aromatic naphthalane constituents with skeletons analogous to bioactive compounds

Cited by 5 publications

References 2 publications

Characterization of Azerbaijani and Croatian brown naphthalane

Characterization of Azerbaijani and Croatian brown naphthalane

Chemical Composition and Physical Properties of “Pale Yellow” Naphtalan

Naphthalan Oil in the Treatment of Psoriasis and Psoriatic Arthritis

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