Study of correlation between forced vital capacity and demand for healthcare services in severe asthmatics

Abstract


 
 
 
 Background: Involvement of the small airways may be related to increased severity and increased demand for health care services and incurring in high costs, private or for the healthcare system. The hyperinflation consequent to this involvement reduces lung volumes, such as FVC, FEV1 and SVC. The aim of this study was to evaluate the correlation between the predicted values of FVC, FEV1 and SVC with the demand for healthcare services by severe asthmatics.
 Methods: We retrospectively evaluated in order of arrival, the medical records of 98 patients with severe asthma, in step 4 treatment in the intercritical period of the disease, correlating the number of times each patient sought health care services represented by admissions to the ER, ICU and hospital wards due to asthma, in the year before the last spirometry and the predicted values of FVC, FEV1 and SVC.
 Results: Our sample showed a clear and significant negative correlation between the predicted values of FVC, FEV1 and SVC and demand for healthcare services.
 Conclusion: For this sample we conclude, that reduced forced vital capacity correlated with asthma severity, defined by greater demand for care in the ER, ICU and hospital ward and was more evident in women.
 
 
 

Glucocorticoid-regulated bidirectional enhancer RNA transcription pinpoints functional genetic variants linked to asthma

“…These findings were corroborated by Micro-C data generated in human embryonic stem cells 39 (Fig 4H), indicating that the rs258760-μ-SNP and the NR3C1 TSS reside within a TAD roughly encompassing chr5:143,100,000-143,400,000 (hg38). To determine whether rs258760 and/or other SNPs within the chr5:143,100,000-143,400,000 TAD have been independently associated with measures of lung function relevant to asthma, we used the Lung Disease Knowledge Portal (https://lung.hugeamp.org/) to visualize the TAD in genomic space along the x-axis relative to GWAS p-values for associations with lung forced vital capacity (FVC) 47 , which has been previously defined as relevant to air pollution and asthma [48][49][50][51] , on the y-axis (Fig 4I). While rs258760 did not achieve statistical significance, there were significant associations between a number of other SNPs within the chr5:143,100,000-143,400,000 TAD and FVC, suggesting genetic variation within this TAD influences lung function.…”