Study of controlled release of ibuprofen magnetic nanocomposites

Pereira, Emiliane Daher; Thomas, Sabu; Souza, Fernando Gomes de; Cardoso, Jéssica da Silva; Filho, Sérgio Thode; Costa, Vítor Corrêa da; Maranhão, Fabíola da Silveira; Lima, Nathali Ricardo Barbosa de; Carvalho, Fernanda Veloso de; Aboelkheir, Mostafa Galal

doi:10.1016/j.molstruc.2021.130067

Cited by 8 publications

(4 citation statements)

References 70 publications

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“…Cinnosome powder (freeze-dried formulation), cinnamaldehyde, cholesterol, Tween 60 and Span 60 were exposed to the ATR-FTIR assessments. The ATR-FTIR spectra were reported in the range of 4000 and 400 cm-1 with a resolution of 2 cm-1 at room temperature [ 23 , 26 ].…”

Section: Methodsmentioning

confidence: 99%

Anti-inflammatory and tissue repair effect of cinnamaldehyde and nano cinnamaldehyde on gingival fibroblasts and macrophages

Ghardashpour,

Saeedi,

Negarandeh

et al. 2023

BMC Oral Health

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Background Recurrent aphthous stomatitis has a complex and inflammatory origin. Among the great variety of medications it is increasingly common to use herbal medicines due to the adverse side effects of chemical medications. Considering the anti-inflammatory properties of cinnamaldehyde and the lack of studies related to the effectiveness of its nano form; This study investigates the effect of cinnamaldehyde and nano cinnamaldehyde on the healing rate of recurrent aphthous stomatitis lesions. Methods In a laboratory experiment, cinnamaldehyde was converted into niosomal nanoparticles. The niosome vesicles diameter and polydispersity index were measured at 25°C using a dynamic light scattering (DLS) Mastersizer 2000 (Malvern Panalytical technologies: UK) and Zetasizer Nano ZS system (Malvern Instruments Worcestershire: UK). After characterizing these particles, the (2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide) [XTT] assay was used to assess the toxicity of cinnamaldehyde and nano cinnamaldehyde on gingival fibroblast (HGF) and macrophage (THP-1) cells. By determining the release of TNF-α, IL-6, and TGF-β cytokines using ELISA kits, the level of tissue repair and anti-inflammatory capabilities of these two substances were evaluated. Results The size and loading rate of the cinnamaldehyde nanoparticles were established after its creation. The optimized nanovesicle exhibited the following characteristics: particle size of 228.75 ± 2.38 nm, PDI of 0.244 ± 0.01, the zeta potential of -10.87 ± 1.09 mV and the drug encapsulation percentage of 66.72 ± 3.93%. PDIs range was between 0.242–0.274. The zeta potential values at 25°C were from -2.67 to -12.9 mV. The results of the XTT test demonstrated that nano cinnamaldehyde exhibited dose-dependent toxicity effects. Moreover, nano cinnamaldehyde released more TGF-β and had better reparative effects when taken at lower concentrations than cinnamaldehyde. Conclusion Nano cinnamaldehyde and cinnamaldehyde are effective in repairing tissue when used in non-toxic amounts. After confirmation in animal models, it is envisaged that these substances can be utilized to treat recurrent aphthous stomatitis.

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Section: Methodsmentioning

confidence: 99%

Anti-inflammatory and tissue repair effect of cinnamaldehyde and nano cinnamaldehyde on gingival fibroblasts and macrophages

Ghardashpour,

Saeedi,

Negarandeh

et al. 2023

BMC Oral Health

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“…Kinetic and spatial control of ibuprofen release was achieved employing magnetite nanoparticles and poly(lactic acid) [81]. Ibuprofen is a nonsteroidal anti-inflammatory, frequently used as antipyretic, analgesic and anti-inflammatory.…”

Section: Fig 1 Magnetization Curves Of (A) Magnetite Nanoparticles; (...mentioning

confidence: 99%

“…Poly(lactic acid) is a biocompatible and biodegradable polymer which is employed in various biomedical applications. The authors successfully developed a nanocomposite with these components and conclude that the kinetic control provided by the polymer and the decrease of toxicity promoted by the spatial control achieved with magnetite nanoparticles, would promote patient comfort and compliance making a more efficient treatment [81].…”

Section: Fig 1 Magnetization Curves Of (A) Magnetite Nanoparticles; (...mentioning

confidence: 99%

Magnetic Nanoparticles for Drug Delivery Applications

Patel¹

2023

Magnetic Nanoparticles for Biomedical Applications

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Magnetic nanoparticles (MNPs) possess different structural, magnetic and dielectric properties compared to bulk magnetic particles and they have found potential applications in the biomedical field (due to their response to applied magnetic field) including MRI, targeted drug delivery, bio sensors, tissue engineering, cancer therapy, and diagnosis, biomaterial coating devices, hyperthermia, cell selection and separation, magnetorelaximetry, antibacterial agent, biomolecules extraction, immunoassay, lab-on-a-chip etc. The synthesis of MNPs can be done by various methods pertaining to the application one is interested in. In present chapter we discuss basic properties (surface and magnetic) of magnetic nano particles and their biomedical applications.

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“…Various studies have reported the synthesis and characterization of these composites through diverse methods. These include single or double emulsion, typically with magnetite functionalized by oleic acid [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]; microwave-induced synthesis involving oleic acid-coated magnetite [ 15 ]; ozone-mediated techniques featuring magnetite functionalized with maleimide benzoic acid (MBA) [ 16 ]; melt compounding synthesis using magnetite functionalized with polymethylhydrogensiloxane (MHX) [ 17 ]; as well as blow fusion [ 1 ], extrusion [ 18 ], doctor-blade [ 19 ], solvent-casting [ 20 , 21 , 22 , 23 , 24 ], matrix-assisted pulsed laser evaporation (MAPLE) [ 25 ], and other melt mixing methods [ 26 ]. A brief summary of these works is provided in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

Sonochemical Synthesis of Magnetite/Poly(lactic acid) Nanocomposites

de França,

Lima,

Barbosa

et al. 2023

Polymers

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Nanocomposites based on poly(lactic acid) (PLA) and magnetite nanoparticles (MNP-Fe3O4) show promise for applications in biomedical treatments. One key challenge is to improve the stabilization and dispersion of MNP-Fe3O4. To address this, we synthesized MNP-Fe3O4/PLA nanocomposites using ultrasound mediation and a single iron(II) precursor, eliminating the need for surfactants or organic solvents, and conducted the process under ambient conditions. The resulting materials, containing 18 and 33 wt.% Fe3O4, exhibited unique thermal behavior characterized by two mass losses: one at a lower degradation temperature (Td) and another at a higher Td compared to pure PLA. This suggests that the interaction between PLA and MNP-Fe3O4 occurs through hydrogen bonds, enhancing the thermal stability of a portion of the polymer. Fourier Transform Infrared (FT-IR) analysis supported this finding, revealing shifts in bands related to the terminal –OH groups of the polymer and the Fe–O bonds, thereby confirming the interaction between the groups. Raman spectroscopy demonstrated that the PLA serves as a protective layer against the oxidation of MNP-Fe3O4 in the 18% MNP-Fe3O4/PLA nanocomposite when exposed to a high-power laser (90 mW). Transmission Electron Microscopy (TEM) and Scanning Electron Microscopy (SEM) analyses confirmed that the synthetic procedure yields materials with dispersed nanoparticles within the PLA matrix without the need for additional reactants.

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Study of controlled release of ibuprofen magnetic nanocomposites

Cited by 8 publications

References 70 publications

Anti-inflammatory and tissue repair effect of cinnamaldehyde and nano cinnamaldehyde on gingival fibroblasts and macrophages

Anti-inflammatory and tissue repair effect of cinnamaldehyde and nano cinnamaldehyde on gingival fibroblasts and macrophages

Magnetic Nanoparticles for Drug Delivery Applications

Sonochemical Synthesis of Magnetite/Poly(lactic acid) Nanocomposites

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