Study of contrasting properties of nanoparticles for optical diffuse spectroscopy problems

Krainov, A D; Агрба, П. Д.; Сергеева, Е. А.; Zabotnov, S. V.; Kirillin, Mikhail

doi:10.1070/qe2014v044n08abeh015494

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…Previous studies have used various optical imaging techniques for GNP detection. Two-dimensional diffuse optical imaging and diffuse optical spectroscopy have been used to detect GNP in phantom 47 – 50 . Optical coherent tomography (OCT) has also been explored for GNP detection 51 – 54 .…”

Section: Introductionmentioning

confidence: 99%

Plasmonic Optical Imaging of Gold Nanorods Localization in Small Animals

Shi

Pourmand

et al. 2018

Sci Rep

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Gold nanoparticles (GNP) have been intensively investigated for applications in cancer imaging and therapy. Most imaging studies focused on microscopic imaging. Their potential as optical imaging probes for whole body small animal imaging has rarely been explored. Taking advantage of their surface plasmon resonance (SPR) properties, we aim to develop a noninvasive diffuse optical imaging method to map the distribution of a special type of GNP, gold nanorods (GNR), in small animals. We developed an integrated dual-modality imaging system capable of both x-ray computed tomography (XCT) and diffuse optical tomography (DOT). XCT provides the animal anatomy and contour required for DOT; DOT maps the distribution of GNR in the animal. This SPR enhanced optical imaging (SPROI) technique was investigated using simulation, phantom and mouse experiments. The distribution of GNR at various concentrations (0.1–100 nM, or 3.5 ug/g–3.5 mg/g) was successfully reconstructed from centimeter-scaled volumes. SPROI detected GNR at 18 μg/g concentration in the mouse breast tumor, and is 3 orders more sensitive than x-ray imaging. This study demonstrated the high sensitivity of SPROI in mapping GNR distributions in small animals. It does not require additional imaging tags other than GNR themselves. SPROI can be used to detect tumors targeted by GNR via passive targeting based on enhanced permeability and retention or via active targeting using biologically conjugated ligands.

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Section: Introductionmentioning

confidence: 99%

Plasmonic Optical Imaging of Gold Nanorods Localization in Small Animals

Shi

Pourmand

et al. 2018

Sci Rep

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Structural and optical properties of nanoparticles formed by laser ablation of porous silicon in liquids: Perspectives in biophotonics

et al. 2020

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The paper discusses the possibility of manufacturing silicon nanoparticles, which are suitable for contrasting biological tissues imaged by optical coherence tomography, by femtosecond laser ablation of porous silicon in various liquids. The manufactured nanoparticles are characterised by average sizes of 87, 112, and 102 nm for cases of ablation in water, ethanol, and liquid nitrogen, respectively, as well as a relatively narrow size distribution, which provides additional advantages for subsequent delivery into biological tissues. Electrochemical etching, which results in the formation of layers of porous silicon, allows the yield of ablation products to be increased several-fold by lowering the ablation threshold, thereby increasing the light scattering efficiency of the prepared suspensions compared with the case of using crystalline silicon as targets. The possibility of obtaining high-contrast images of a biotissue phantom based on an agar gel with embedded nanoparticles is shown. The magnitude of the contrast depends on the liquid used for ablation and correlates with the values of the reduced scattering coefficient of the studied suspensions.

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