Study of Continuous Extraction Process Utilizing Supercritical Fluid for <i>Ganoderma lucidum</i>

Abstract

Gandoerma lucidum is equipped with several kinds of bioactivity, and is considered as a very important medicinal ingredient of regimen and health care for Chinese medicine. This study has employed supercritical fluid extraction and fractionation device to continuously prepare ganoderic acid and phenolic compounds of ganoderma lucidum, and experiment design is conducted in coping with diverse pressure, temperature, and flow rate as experiments variables to conduct experiment design. Thus supercritical extraction is being employed to collect and extract different materials from sections, so that optimized trend of terms and conditions can be used to predict the test. As shown from the results, if lower temperature as 40°C and high pressure 30 MPa are chosen, working in conjunction with flow rate of low sample 3 ml/min, it can reach the optimized effect of purification with regarding to ganoderic acid and phenolic compounds. If the concentration of fractionation liquid stays at 1.0 g/L, its power of scavenging will be F1(60%)＞F2(50%)＞F3(30%)＞R(28%), whereas half of the inhibition concentration will respectively be R(2.67 g/L)＞F3(2.29 g/L)＞F2(0.97 g/L)＞F1(0.76 g/L), and the antioxidant capacity of F1 fractionation liquid is considered the best.

Natural Bio-Compounds from Ganoderma lucidum and Their Beneficial Biological Actions for Anticancer Application: A Review

“…All these compounds are responsible for antioxidant activity [186]. Triterpenoid compounds were documented by Lin et al in 2015 and Kolniak-Ostek et al in 2022 [188,192]. Polysaccharide compounds were described by Lin et al in 2015 [188].…”

“…Triterpenoid compounds were documented by Lin et al in 2015 and Kolniak-Ostek et al in 2022 [188,192]. Polysaccharide compounds were described by Lin et al in 2015 [188]. Polyphenolic compounds were investigated by Rahman et al in 2020 and by Kolniak-Ostek et al in 2022 [21,192].…”