Study of consanguinity of the population of northern Morocco

Habibeddine, Lamiaa; Ouardani, Mohamed; Ossmani, Hicham El; Amzazi, Said; Talbi, Jalal

doi:10.4172/2157-7145.1000406

Cited by 9 publications

(9 citation statements)

References 7 publications

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“…Previous works showed that the national consanguinity rate in Morocco varied between 19.81 and 28% [6]. Northern regions registered the highest rates with 39.4% (FI = 0.02033) in the Tangier-Tetouan region [6] and 24.37% (FI = 0.008038) in the Tangier-Tetouan-Al Hoceima region [4]. The Gharb-Chrarda-Beni Hssen region, the neighbor region, also registered a high rate of consanguinity (22.8%) [15].…”

Section: Discussionmentioning

confidence: 99%

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Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study

Laghmich

Ismaili

Zian

et al. 2019

BioMed Research International

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Consanguinity is a social behavior characterized by the arrangement of marriages between relatives. It coincides generally with the geographic distribution of recessive genetic diseases as it increases the likelihood of homozygosis and, consequently, the incidence of their pathologies in the population. In this pilot study, we assess the effect of inbreeding on the burden of hemoglobinopathies in Northern Morocco. From January 2016 to December 2018, 197 children born in the studied region to three ancestral generations and diagnosed with hemoglobinopathies were subject to investigation. The rate of consanguinity in the parents' generation of children with hemoglobinopathies was 50.25%, with first cousin marriages accounting for 68.69% of consanguineous unions (FI = 0.02). The corresponding rates in the general population, based on a sample of N = 900, were 29.67% and 82.02%, respectively. The marriages between first cousins are the most common among the other types of consanguineous unions. Our study propounds that consanguinity substantially contributes to the hemoglobinopathy burden in the studied region and has changed little over time. Refraining from consanguineous marriages and detecting couples at risk could contribute to the reduction of the incidence of genetic diseases in our country.

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Section: Discussionmentioning

confidence: 99%

“…Eleven percent of the global population is married to a kinsperson [3]. The Middle East and North Africa are known for high levels of consanguineous kinships compared to Western countries [4]. In Morocco, consanguinity varies in the range of 19.81–28% [5].…”

Section: Introductionmentioning

confidence: 99%

Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study

Laghmich

Ismaili

Zian

et al. 2019

BioMed Research International

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“…This finding is consistent with the previous study which showed that the consanguinity rate in Eastern Morocco region is higher than the national average (29.58% vs. 22.79%) (Mohammed et al, 2019;Talbi et al, 2007). Thereby, it is not surprising to see a strong occurrence of autosomal recessive diseases such as thalassemia in our population (Habibeddine et al, 2018;Jaouad et al, 2009;Laghmich et al, 2019).…”

Section: Discussionmentioning

confidence: 75%

Molecular heterogeneity of β‐thalassemia variants in the Eastern region of Morocco

Belmokhtar

Lhousni

Errahhali

et al. 2022

Molec Gen & Gen Med

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Background β‐thalassemia syndromes are the most common hereditary blood disorders in the world and are recognized as a major health problem in Morocco. They are characterized by the reduction or the absence of β‐globin chain synthesis. The severity of the disease depends on the nature of the variants affecting the β‐globin gene ( HBB ), and each ethnic group has its own mutation spectrum. Hereby, we present, for the first time, the molecular profile of β‐thalassemia in the Eastern region of Morocco. Methods This study concerns 39 cases from 33 families who were enrolled in the BRO Biobank. Nineteen were diagnosed with β‐thalassemia major and 20 with β‐thalassemia minor. To detect mutations of the β‐globin gene, we have used RFLP‐PCR and Sanger sequencing. Results Nine known β‐thalassemia variants have been identified. Among these, we reported, for the first time in the Moroccan population, the Czechoslovakian variant C38/39(‐C) at homozygous state. The C39(C > T) was the most frequent variant (72.54%), followed by FSC5(‐CT) (5.88%), FSC6(−A), IVS‐1‐110(G > A), −29(A > G), C38/39(‐C) (3.92% each), and finally by IVS‐I‐1(G > A), IVS‐II‐1(G > A), and −56(G > C) (1.96%). Of particular interest this mutational spectrum of β‐thalassemia is very different from that found in previous studies in Morocco or in other North African countries. Conclusion This study is the first contribution to the description of the molecular profile of β‐thalassemia in the Eastern region of Morocco. It shows the high molecular heterogeneity of β‐thalassemia in our country. Therefore, these results can be valuable for the implementation of carrier screening, genetic counseling, and prenatal diagnosis programs.

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“…However, unlike ALS, its systemic involvement is far-reaching and responsible for a clinical picture including several neurological findings, such as motor and sensory neuropathies, cerebellar impairment, visual and auditory issues, as well as musculoskeletal deformities, cardiovascular problems and diabetes [ 4 ]. The condition is an autosomal recessive disorder and, given the high rate of consanguinity in several areas in the country, we suspect there might be a higher prevalence of the condition in Morocco than elsewhere [ 37 ]. Out of the 5 cases identified in our patients, 2 were a brother and a sister from a consanguineous marriage.…”

Section: Discussionmentioning

confidence: 99%

Etiological profile of peripheral neuropathies in an academic hospital in southern Morocco

Poda

Klevor

Salym

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Background Peripheral neuropathies constitute a common complaint in general and neurology practice, and are a source of handicap to patients. Epidemiological data in the Middle East and North Africa region as well as in the African continent are sparse. Nevertheless, regional etiological profiles are crucial in navigating the diagnostic maze of neuropathies. This study outlines the etiological profile of peripheral neuropathies in an academic hospital in southern Morocco. Results A total of 180 cases were recorded in a span of 8 years (22.5 cases per year). The mean age of patients was 42.35 years. Male gender was predominant (68.88%), with a sex ratio of 2.2. Motor symptoms were the most frequently reported (86.6%). The axonal form (40.56%) was the most frequently encountered electrophysiologic form. The most frequent etiologies in the study were diabetes (26.7%), acute polyradiculoneuropathy (26.1%) and amyotrophic lateral sclerosis (16.1%). Alcohol neuropathy was found in 2.2% of the cohort. No cause was found in 5% of cases. Outcome was mostly favorable under treatment, although 10 deaths due to acute polyradiculoneuropathy were recorded (mortality = 21.3%). Conclusions Knowledge of the etiological profile of peripheral neuropathies should guide clinicians to an early diagnosis and aid in an adapted management of patients.

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Study of consanguinity of the population of northern Morocco

Cited by 9 publications

References 7 publications

Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study

Hemoglobinopathies in the North of Morocco: Consanguinity Pilot Study

Molecular heterogeneity of β‐thalassemia variants in the Eastern region of Morocco

Etiological profile of peripheral neuropathies in an academic hospital in southern Morocco

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