Study of conformational and functional changes caused by binding of environmental pollutant tonalide to human serum albumin

Unveiling the binding details and esterase-like activity effect of methyl yellow on human serum albumin: spectroscopic and simulation study

“…A low c 2 means a good t. 15 The tting results showed that the value was about 1, indicating that the curve tting was accurate and the result was reliable. The uorescence lifespan of HSA was unaffected by the addition of MY, which was negligible (<0.1 ns).…”

“…13 HSA is very special because of its internal hydrophobic cavity and special affinity, enabling its easy binding to small molecules. [14][15][16] Most small molecules that have been shown to attach to HSA are mostly at Sudlow's site I (in subdomain IIA) and site II (in subdomain IIIA). 17,18 At the same time, azo dyes can bind reversibly and effectively with HSA, which can regulate the effective concentration of limiting toxicity.…”

Characterization of interactions of montelukast sodium with human serum albumin: multi-spectroscopic techniques and computer simulation studies

“…When the excitation wavelength is 280 nm, Trp and Tyr are mainly excited, while at 295 nm, only Trp is excited. 19 Many small-molecule ligands may influence the microenvironment around the fluorescent chromophores of HSA after binding to HSA, and ultimately lead to the change in the fluorescence intensity.…”

Epicatechin attenuates lead (Pb)-induced cognitive impairment in mice: regulation on Nrf2 signaling pathway, and interference on the interaction between Pb with albumin

“…showed that EC increased the binding distance between BSA and Pb 2+ which was speculated that it may be due to the formation of a complex between Pb 2+ and EC, thereby reducing the binding affinity of Pb 2+ to BSA. The results showed that after chelating with EC, the effect of Pb 2+ -EC complex on the stability of BSA molecular structure was lower than the conformational change of BSA caused by the interaction between BSA and Pb 2+ [43]. The existence of EC hindered the binding of Pb 2+ to BSA to some extent.…”