Study of Clinicobiochemical Spectrum of Hypothyroidism

Somanna, Sampath; Singh, Poonam; Somani, Babu Lal; Arora, MM; Batra, HS; Harith, Arun Kumar; Ambade, Vivek

doi:10.1016/s0377-1237(07)80142-0

Cited by 9 publications

(9 citation statements)

References 7 publications

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“…In this study, they found that the mean age of females with subclinical hypothyroidism is 5.4 years less than hose with overt hypothyroidism. 7 In present study, we found an association in the occurrence of menorrhagia (61.6%) in hypothyroid women. In a retrospective analysis by Andrew D Weeks among 50 patients with myxoedema, 28 (56%) had menstrual disturbances and the most common complaint was menorrhagia (36%).…”

Section: Discussionsupporting

confidence: 56%

Influence of thyroid gland in women with abnormal uterine bleeding in reproductive age group

Marimuthu¹,

Loganathan²

2017

Int J Reprod Contracept Obstet Gynecol

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Background: Abnormal Uterine Bleeding is a common complaint encountered in Gynaecology OPD. It occurs in 9-14% of women from Menarche to Menopause affecting quality of life imposing financial burden. Thyroid dysfunction causes broad spectrum of reproductive disorders from abnormal sexual development, menstrual irregularities, infertility and premature menopause. Thyroid disorders are 10 times more common in women and increased prevalence of thyroid disorders in women is possibly due to auto immune nature. Methods: This Prospective study population consisted of 250 women attending the Gynaecology Outpatient Clinic, in Government Dharmapuri Medical College Hospital, with complaints of bleeding problems during menstruation in the age group of 18 to 45 years. Results: Of 250 cases of abnormal uterine bleeding in reproductive age group attending the outpatient department about 68 cases have thyroid dysfunction. The common thyroid dysfunction in our study was hypothyroidism which comprises about 15.6% similarly other thyroid dysfunction are hyperthyroidism in 7.2% and subclinical hypothyroidism in 3.2% and subclinical hyperthyroidism 1.2%. Conclusions: It brings into focus the increased incidence of hypothyroidism among women with menorrhagia and amenorrhea. And increased incidence of hyperthyroidism in women with oligomenorrhea. Early detection by selective screening and specific pharmacotherapy for subclinical thyroid disease early in the course of the disease will prove to be a superior alternative to surgical treatments like hysterectomy.

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Section: Discussionsupporting

confidence: 56%

Influence of thyroid gland in women with abnormal uterine bleeding in reproductive age group

Marimuthu¹,

Loganathan²

2017

Int J Reprod Contracept Obstet Gynecol

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“…In this study, they found that the mean age of females with subclinical hypothyroidism was 5.4 years less than those with overt hypothyroidism. 10 37.5% of cases of hypothyroid (both subclinical and overt) in our study, were exhibiting menorrhagia. The similar results were seen in 57.13% patients in the study by Nair RV et al and in 46.15% patients in the study by Bharucha M et al 11,12 Douglas et al observed that 22.3% of cases with menorrhagia had subclinical hypothyroidism.…”

Section: Discussionmentioning

confidence: 48%

Evaluation of thyroid disorders in abnormal uterine bleeding

Sharma¹,

Patil

2018

Int J Reprod Contracept Obstet Gynecol

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Background: Abnormal uterine bleeding(AUB) is a common clinical presentation in gynecology. Alteration in thyroid hormones level has been associated with menstrual disturbances. This study is aimed to know the prevalence of thyroid disorders amongst AUB patients and also the different patterns of menstrual abnormalities associated with thyroid disorders.Methods: 100 Patient of clinically diagnosed AUB were taken from gynecology OPD. All the patients from 19 to 45 age groups presenting with menstrual disturbances were tested for thyroid function by measuring ST3, ST4, and S.TSH.Results: Out of 100 women of AUB, majority were in the age group of 31-40 years (38%), 54% were multiparous and 44% presented with menorrhagia. 65% were euthyroid, 17% had subclinical hypothyroidism, 15% had overt hypothyroidism and 3% were diagnosed as hyperthyroid. Subclinical hypothyroidism, overt hypothyroidism and hyperthyroidism were detected mostly in the age group of 31-40 years. The commonest bleeding abnormalities in hypothyroid patient were menorrhagia and polymenorrhoea. While most of the hyperthyroid cases were oligomenorrhoic.Conclusions: The study concludes that biochemical evaluation of thyroid function is an easy, reliable method and should be made mandatory in all cases of AUB.

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“…[23] Several other studies also have reported a high prevalence of subclinical hypothyroidism among Indians. [24] Among patients from coastal Andhra Pradesh, Shekhar et al 2011 had observed a prevalence of 8.29% for subclinical hypothyroidism [13] and our prevelance was 7.86. Similar to most studies a higher number of women subjects were detected with subclinical hypothyroidism.…”

Section: Discussionmentioning

confidence: 57%