Study of clinical profile of painful crisis in hospitalized children of sickle cell anemia

Clinical Profile of Patients of Sickle Cell Crisis in a Rural Tertiary Care Hospital

“…In contrast, patients with the highest deformability, and not under hydroxyurea therapy, seem to develop more frequently vaso-occlusive like events. 5 Although less studied, RBC aggregation properties are very different between SCA and healthy individuals and it was demonstrated that increased RBC aggregates strength could be involved in some complications. Finally, several studies have established that the vascular system of SCA patients could not fully compensate any increase in blood viscosity because of the loss of vascular reactivity, which may result in vaso-occlusive crises.…”