Study of Clinical Features and Management of Vernal Keratoconjunctivitis

Nagrale, Prachee

doi:10.18535/jmscr/v5i1.86

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Our results more or less agree with two studies, one was done on allergic conjunctivitis patients and revealed that 66% had positive family history of atopy 13 and another one on allergic rhinitis in which 64.4% of patients had positive family history of allergic disease 14 . Our study revealed slight predominance of male patients (53.1%) which is lower than that reported by Nagrale and coworkers 15 (82.5%). While female preponderance was reported by Kosrirukvongs et al 13 and also by Malu 16 as 51.2% females among patients with allergic conjunctivitis.…”

Section: Discussioncontrasting

confidence: 81%

Immunoblotting Technique Versus Skin Prick Test for Detection of Allergen Specific Immunoglobulin E in Allergic Conjunctivitis

Haggag

Aboelazm

Al-Gazzar

et al. 2017

Journal of Ophthalmology and Related Sciences

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Introduction: Skin prick test (SPT) is the most sensitive and reliable method of detecting the causative allergens and considered the gold standard method for allergy testing, it is also simple, quick and cheap. However it has an invasive nature requires multiple skin pricks, painful for children and difficult if skin diseases coexist. SPT can be affected by antihistaminics and corticosteroids. Hence, an immunoblotting technique as an alternative test for IgE determination has been developed, which is lesser invasive. Aim: To evaluate the immunoblot test by comparing it to SPT in diagnosis of allergic conjunctivitis. Patients and Methods: Immunoblot test was done for 32 patients clinically diagnosed as allergic conjunctivitis, either alone or associated with allergic rhinitis and / or bronchial asthma and who gave positive SPT with one or more of 11 natural allergenic extracts. Results: Overall diagnostic performance of immunoblot test in comparison to SPT for detection of all studied aeroallergens showed 27.5% sensitivity, 98.0% specificity, 97.0% positive predictive value, 33.2% negative predictive value and 46.2% diagnostic accuracy. Conclusion: Since immunoblotting technique has low sensitivity and high specificity, hence it can be used as confirmatory test secondary to SPT for diagnosis of causative allergens.

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Section: Discussioncontrasting

confidence: 81%

Immunoblotting Technique Versus Skin Prick Test for Detection of Allergen Specific Immunoglobulin E in Allergic Conjunctivitis

Haggag

Aboelazm

Al-Gazzar

et al. 2017

Journal of Ophthalmology and Related Sciences

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“…A slight preponderance of male patients (55%) in allergic conjunctivitis group was observed which agrees with Charani & Sailaja 18 and Nagrale et al 19 who reported 57.4% and 82.5% male preponderance respectively, while Almaliotis et al 20 reported a slight female preponderance (58.19%) among allergic conjunctivitis patients. This male predominance may be linked to lifestyles being more engaged in outdoor activities to a greater extent than females in our society.…”

Section: Discussionsupporting

confidence: 77%

Association of GATA3 gene polymorphism with allergic conjunctivitis and allergic rhinitis

Ahmed

Nasr²,

Al-Kaffas³

et al. 2022

Egyptian Journal of Medical Microbiology

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Background: The elaboration of allergic diseases as allergic conjunctivitis (AC) and allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. Trans-acting T-cell-specific transcription factor (GATA3) is a transcription factor that readjust the T helper (Th2) cell response. High expression of GATA3 in Th2 cells elevate Th2 differentiation, resulting in the release of large amounts of immunoglobulin E (IgE) from B-cells and eventually aggravating allergic disease.Objective: The present work aims to investigate the association between GATA3 single nucleotide polymorphism (SNPs) with allergic conjunctivitis and allergic rhinitis at locus rs1269486 in the promoter region using RFLP-PCR among a group of Egyptian patients. Methodology: Cross sectional study included a total of 60 participants; 20 AC patients, 20 AR patients and 20 healthy individuals. Peripheral blood samples were taken and DNA was extracted followed by RFLP-PCR to analyze GATA3 (rs1269486) SNPs. Results: A substantially higher prevalence of the homozygous rs1269486 GG genotype and G allele appeared in the AR patients and AC patients, compared to the control subjects (P-value 0.003, and 0.002 respectively). Conclusion: This study showed a highly significant association between GATA3 SNP at locus, rs1269486 in the promoter region in the studied Egyptian patients with allergic rhinitis and allergic conjunctivitis suggesting the role of GATA3 gene polymorphism in the pathogenesis of AC and AR.

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“…Common clinical signs of VKC are conjunctival hyperemia, papillary hypertrophy, mucous discharge, Hornertrantas dots, and corneal involvement 3 . V Treatment options available for Vernal keratoconjunctivitis include topical antihistamines, mast cell stabilizers, NSAIDS, steroids, and immunomodulators 4 . Prolonged treatment course with multiple remissions is the major threat faced among VKC patients.…”

mentioning

confidence: 99%

Efficacy of 0.03% Dermatological Tacrolimus Ointment for Refractory Vernal Keratoconjunctivitis.

Imtiaz

Qayyum²,

Iqbal³

et al. 2020

pak J Ophthalmol

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Purpose: To determine the efficacy of 0.03% dermatological tacrolimus ointment in patients with refractory vernal keratoconjunctivitis Study Design: Quasi-experimental study Study Place and Duration: Eye Department, DHQ-Teaching Hospital, Gujranwala, Pakistan from April 2018 to March 2019 Material and Methods: After approval from hospital ethical committee and obtaining written informed consent from each patient/guardian, patients of either gender between 4-16 years of age with VKC not responding to conventional treatment for more than 8 weeks or having steroid-induced complications were included in this study. Dermatological tacrolimus ointment 0.03% started to be placed in inferior fornix in BD frequency along with topical lubricants. Patients were followed up on a regular schedule. Individual symptoms score was assessed from the questionnaire and signs score from observer’s clinical assessment. Data were analyzed using SPSS v23.0. P-value <0.05 was considered as statistically significant. Results: 40 eyes of 20 patients were included in this study. Out of which 4(20%) were female and 16 were male (80%). Mean baseline score for clinical symptoms was 6.65±1.81 that reduced to 1.65±0.81 after 12 weeks treatment course of tacrolimus with a significant p-value of 0.006 (p<0.05). Mean baseline score for clinical signs was 5.9±1.59 that improved to 1.80±0.83 after 12 weeks treatment course with a statistically significant p-value of 0.003 (p<0.05). Conclusions: In conclusion, topical tacrolimus dermatological ointment 0.03% is highly effective in refractory VKC and can be safely used as an alternative in VKC patients who are steroid-responders.

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Study of Clinical Features and Management of Vernal Keratoconjunctivitis

Cited by 4 publications

References 15 publications

Immunoblotting Technique Versus Skin Prick Test for Detection of Allergen Specific Immunoglobulin E in Allergic Conjunctivitis

Immunoblotting Technique Versus Skin Prick Test for Detection of Allergen Specific Immunoglobulin E in Allergic Conjunctivitis

Association of GATA3 gene polymorphism with allergic conjunctivitis and allergic rhinitis

Efficacy of 0.03% Dermatological Tacrolimus Ointment for Refractory Vernal Keratoconjunctivitis.

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