Study of Chronic Hepatopathy in Patients With Sickle Cell Disease

Maher, Maha M; Mansour, Amany H.

doi:10.4021/gr2009.12.1327

Cited by 13 publications

(17 citation statements)

References 15 publications

(16 reference statements)

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“…However, serum albumin and direct bilirubin showed no statistically significant difference. So, our study shares similar findings with Gardner K et al 2014 and Mahera MM et al 2009 [9,10]. These findings suggest that a multifactorial etiology can exist for occurrence of liver disease in SCA patients…”

Section: Discussion:-supporting

confidence: 81%

Liver Involvement in Sickle Cell Trait: A Case Control Study Among Nepalese Indigenous Tharu Community.

Bhatta¹,

Thapa²,

Ranabhat³

et al. 2017

IJAR

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Background: Sickle cell trait is not usually regarded as a disease state because it may present several types of health complications that are either uncommon or mild and have not been thoroughly investigated. This article aims to describe the relationship between sickle cell trait (SCT) and liver function test (LFT) parameters in tharu community of western tarai region of Nepal. Method: Sixty two (62) subjects divided into control subjects (n = 31) and heterozygous sickle cell patients ( n = 31) were recruited for the study and were investigated for a liver function tests including the measurement of total protein, albumin, globulin, total bilirubin, direct bilirubin, indirect bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH) in both groups. Mean, Standard deviation, Students T test analysis were used for analysis of results. Result: The serum total protein, globulin, total bilirubin, indirect bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH) were significantly higher in SCT patients than in controls, with P values of 0.014, <0.001, 0.003, 0.006, <0.001, <0.001 and <0.001 respectively. However, there were no significant difference in the mean value of albumin and direct bilirubin. There was strong correlation noticed between AST and LDH in the test group. Conclusion: It appears that abnormal liver function tests in patients with sickle cell trait poses an uncertain threat for liver disease. The liver functions of the SCT patients were significantly compromised as compared to controls. Studies at molecular level are needed to understand the pathophysiology and progression of liver disease in sickle cell anemia. It is advisable that liver function tests be interpreted with caution in these patients.

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Section: Discussion:-supporting

confidence: 81%

Liver Involvement in Sickle Cell Trait: A Case Control Study Among Nepalese Indigenous Tharu Community.

Bhatta¹,

Thapa²,

Ranabhat³

et al. 2017

IJAR

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“…[3] d) Factors associated with primary disease but related with transfusion therapy, hemosiderosis and viral hepatitis. [1,3,4] Section: Paediatrics…”

Section: Discussionmentioning

confidence: 99%

“…Similar results were seen in the present study. [12] Limitations • Work up to r/o primary liver pathology such as liver biopsy or viral markers were not done.…”

Section: Abdominal Ultrasound-mentioning

confidence: 99%

“…It is characterized by chronic haemolytic anaemia and vaso-occlusive crises arising from widespread vascular occlusion by sickled red blood cells leading to multiple organ infarctions. [1] Sickle cell disease is a multisystem disorder can affect any part of the body .One of the main organ to be affected is hepatobiliary system. [2] Liver and biliary tract abnormalities are common in sickle cell disorder.…”

Section: Introductionmentioning

confidence: 99%

“…The liver can be affected by a number of complications due to the disease itself and its treatment. 1 In patients of sickle cell disease, there are repeated attacks of jaundice, hepatic infarction, cholelithiasis, choledocholithiasis, acute and chronic hepatitis and cirrhosis. [3] The hepatobiliary complications are due to haemolysis, the problems of anaemia, transfusion management, the consequences of sickling, vaso-occlusion.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Study of Hepatobiliary Involvement in Children with Sickle Cell Disease

Bokade¹,

Chauhan²,

Dhole³

2017

Ann. Int. Med. Den.Res.

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Sickle Hepatopathy

Praharaj

Anand

2021

Journal of Clinical and Experimental Hepatology

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Sickle hepatopathy is an umbrella term describing various pattern of liver injury seen in patients with sickle cell disease. The disease is not uncommon in India; in terms of prevalence, India is second only to Sub-Saharan Africa where sickle cell disease is most prevalent. Hepatic involvement in sickle cell disease is not uncommon. Liver disease may result from viral hepatitis and iron overload due to multiple transfusions of blood products or due to disease activity causing varying changes in vasculature. The clinical spectrum of disease ranges from ischemic injury due to sickling of red blood cells in hepatic sinusoids, pigment gall stones, and acute/chronic sequestration syndromes. The sequestration syndromes are usually episodic and self-limiting requiring conservative management such as antibiotics and intravenous fluids or packed red cell transfusions. However, rarely these episodes may present with coagulopathy and encephalopathy like acute liver failure, which are life-threatening, requiring exchange transfusions or even liver transplantation. However, evidence for their benefits, optimal indications, and threshold to start exchange transfusion is limited. Similarly, there is paucity of the literature regarding the end point of exchange transfusion in this scenario. Liver transplantation may also be beneficial in end-stage liver disease. Hydroxyurea, the antitumor agent, which is popularly used to prevent life-threatening complications such as acute chest syndrome or stroke in these patients, has been used only sparingly in hepatic sequestrations. The purpose of this review is to provide insights into epidemiology of sickle cell disease in India and pathogenesis and classification of hepatobiliary involvement in sickle cell disease. Finally, various management options including exchange transfusion, liver transplantation, and hydroxyurea in hepatic sequestration syndromes will be discussed in brief. (

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Study of Chronic Hepatopathy in Patients With Sickle Cell Disease

Cited by 13 publications

References 15 publications

Liver Involvement in Sickle Cell Trait: A Case Control Study Among Nepalese Indigenous Tharu Community.

Liver Involvement in Sickle Cell Trait: A Case Control Study Among Nepalese Indigenous Tharu Community.

Study of Hepatobiliary Involvement in Children with Sickle Cell Disease

Sickle Hepatopathy

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