Study of Chlamydia trachomatis Infection in Infertile Females at a  Tertiary Care Hospital in Mumbai, India

Lohi, K.M.; Kumar, Chaya A.; Fonseca, Michelle; Baveja, Sujata; Panchal, Sagar

doi:10.20546/ijcmas.2018.703.234

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…In frequent infections, salpingitis, tubular ovarian abscess, and infertility are also possible, and ectopic pregnancy is an indirect complication of this infection. The tissue damage following chlamydia trachomatis is noteworthy because it happens due to late diagnosis and treatment (6)(7)(8)(9)(10). According to the World Health Organization (WHO) guidelines, only treatment regimens that have more than 95% efficacy are recommended for STIs (40).…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Single-Dose Azithromycin Versus its Combination With Moxifloxacin Based on the Treatment of Chlamydial Cervicitis: A Study Protocol for a Randomized Clinical Trial

Mohammadzadeh

Dolatian

Jorjani

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

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Objectives: Chlamydia trachomatis is globally reported as a pathogenic infection and is the most common bacterial cause of sexually transmitted infection (STI) in most countries. In addition, chlamydial cervicitis and the adverse complications of the first line treatment, namely, azithromycin failure are highly prevalent. Thus, the present study will be conducted to determine and compare the effects of single-dose azithromycin and its combination with moxifloxacin based on syndromic and etiologic methods in the diagnosis and treatment of chlamydial cervicitis. Materials and Methods: This is a study protocol for a randomized clinical trial which will be performed at the Women’s Clinics and Health Centers in Amol, Iran during 2018. Further, the study will evaluate women with cervicitis complaints, who have a proven case of chlamydial cervicitis through syndromic or etiologic diagnostic methods and meet the inclusion criteria for the study population. Discussion: To the best of our knowledge, this trial will be the first study to explore the effects of single-dose azithromycin in combination with moxifloxacin in the treatment of chlamydial cervicitis. The results of this trial will further reveal the diagnostic value of syndromic and etiologic methods in the diagnosis of chlamydial cervicitis.

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Section: Discussionmentioning

confidence: 99%

The Effectiveness of Single-Dose Azithromycin Versus its Combination With Moxifloxacin Based on the Treatment of Chlamydial Cervicitis: A Study Protocol for a Randomized Clinical Trial

Mohammadzadeh

Dolatian

Jorjani

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

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“…Chlamydia infection also increases the likelihood of Human Immunodeficiency Virus (HIV) comorbidity. Infertility is one of the common complications of untreated chlamydial cervicitis, whose likelihood increases with the frequency of recurrence or treatment failure (9,10). The proposed treatment of Chlamydial cervicitis is a single dose of oral azithromycin or oral doxycycline 100░mg twice daily for seven days.…”

Section: Introductionmentioning

confidence: 99%

Urogenital chlamydia trachomatis treatment failure with azithromycin: A meta-analysis

Mohammadzadeh

Dolatian

Jorjani

et al. 2019

IJRM

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Background: Chlamydia Trachomatis is one of the most common pathogens transmitted through the genital tract in humans that leads to urogenital infection. Objective: Given the high prevalence of chlamydia infection and its adverse effects on the health of women and men, the present meta-analysis was conducted to determine the rate of treatment failure with azithromycin. Materials and Methods: Databases including MEDLINE, ISI - Web of Science, PubMed, EMBASE, Scopus, ProQuest, and Science Direct were searched for articles published between 1991 and 2018. The quality of the selected articles was assessed using the Cochrane risk of bias assessment tool. Heterogeneity was determined using the I2 and Cochrane Q-Test. Subgroup analysis and meta-regression were used to compare the prevalence rates on different levels of the variables. Results: A total of 21 articles that met the inclusion criteria were ultimately assessed. The pooled estimate of azithromycin failure rate was 11.23% (CI 95%: 8.23%-14.24%). Also, the azithromycin failure rate was 15.87% (CI 95%: 10.20%-21.54%) for the treatment of urethritis, 7.41% (CI 95%: 0.60%-14.22%) for cervicitis, and 7.14% (CI 95%: 10.90%-3.39%) for genital chlamydia. The pooled estimate of failure rate difference was 2.37% (CI 95%: 0.68%-4.06%), which shows that azithromycin has a higher failure rate in the treatment of chlamydia compared to doxycycline and other examined medications. The meta-regression results showed that the patient’s age contributes significantly to the heterogeneity for azithromycin treatment failure rate (β = 0.826; p = 0.017). Conclusion: Azithromycin has a higher failure rate than doxycycline and other studied medications in treating urogenital chlamydia infections. Key words: Azithromycin, Chlamydia trachomatis, Urogenital, Treatment failure, Meta-analysis.

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Study of Chlamydia trachomatis Infection in Infertile Females at a Tertiary Care Hospital in Mumbai, India

Cited by 2 publications

References 11 publications

The Effectiveness of Single-Dose Azithromycin Versus its Combination With Moxifloxacin Based on the Treatment of Chlamydial Cervicitis: A Study Protocol for a Randomized Clinical Trial

The Effectiveness of Single-Dose Azithromycin Versus its Combination With Moxifloxacin Based on the Treatment of Chlamydial Cervicitis: A Study Protocol for a Randomized Clinical Trial

Urogenital chlamydia trachomatis treatment failure with azithromycin: A meta-analysis

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