Study of chicken liver and spleen by Mössbauer spectroscopy

Structural and magnetic study of the iron cores in iron(III)-polymaltose pharmaceutical ferritin analogue Ferrifol®

“…For Mössbauer measurements the Ferrifol® powder was placed into Plexiglas sample holder with a diameter of 2 cm and tightly pressed accounting the final sample thickness to be ~8 mg Fe/cm 2 . In some cases, 100 mg of powdered lyophilized human liver ferritin (prepared as shown in [34]) placed into similar sample holder was used as a reference material.…”

“…Using Mössbauer spectroscopy in our earlier studies of ferritin and some pharmaceutical analogues (iron-dextran complexes including Imferon®, iron-polymaltose complexes Ferrum Lek and Maltofer®) we developed heterogeneous iron core models in order to fit their Mössbauer spectra, which implies different regions/layers in ferric hydrous oxide cores with corresponding different Journal Pre-proof J o u r n a l P r e -p r o o f 3 quadrupole splitting mainly [33][34][35][36][37][38][39][40][41][42]. Moreover, recently we observed unusual temperature dependences of some Mössbauer parameters for ferritin and Ferrum Lek [39] and then for Maltofer® which were interpreted as a result of rearrangement of more and less close-packed FeOOH regions/layers in the iron cores [42].…”

Mössbauer spectroscopy: Application in biomedical research

“…Comparative studies of the iron oxide deposits in liver, spleen and pancreas from Thai patients with β-thalassemia/hemoglobin E and Australian patients with β-thalassemia revealed some differences of mineral iron core structures shown by small variations of ΔE Q and δ [40]. Preliminary studies of liver and spleen tissues from normal chicken and chicken with lymphoid leukemia revealed small variations of ΔE Q and δ between normal and leukemia tissues [41,42]. These works may be also considered as studies of "small" variations of the iron electronic structure.…”

“…Iron containing pharmaceuticals for treatment of iron deficiency anemia were studied for characterization of the iron state and for the detection of iron containing impurities. An analysis of injectable iron dextran and iron polysaccharide complexes, which were models of ferritin and contained ferric hydrous oxides, showed small variations of Mössbauer parameters and the presence of ferrous impurities [41,[87][88][89][90][91][92][93][94][95]. Vitamins and dietary supplements containing various ferrous compounds were also characterized and the presence of ferrous and ferric impurities was detected in several vitamins and dietary supplements [96][97][98][99].…”

Mössbauer spectroscopy in biomedical research

“…We have used Mo ¨ssbauer spectroscopy to study a combination of the direct and indirect effect of g-rays and electrons as well as microwave heating on concentrated oxyhemoglobin solution. [39][40][41][42][43][44][45][46][47] Mo ¨ssbauer spectra of oxyhemoglobin in red blood cells and solution irradiated with g-rays (E max ¼ 15.5 MeV) and electrons (E ¼ 10 MeV) are shown in Fig. 7.…”