Study of CD69 antigen expression and integrity of leukocyte cellular membrane in stored platelet concentrates following irradiation and treatment with Mirasol® PRT System

Abstract

Background. Leukocytes in transfused blood components, particularly residual lymphocytes, have been shown to contribute to the occurrence of various adverse reactions. One of the most severe is transfusionassociated graft versus host disease (TA-GvHD) following transfusion of blood components contaminated with immunocompetent T lymphocytes. Irradiation is a routine method for protection against TA-GvHD. According to the literature, some pathogen reduction methods have also been proven effective for the inactivation of T lymphocytes, and so they may be considered as an alternative to irradiation.

Current status and achievements of Polish transfusion medicine

“…Since there is no effective Jolanta Antoniewicz-Papis et al, Polish transfusion medicine treatment for TA-GvHD, the only way to protect patients at risk of this serious adverse reaction is irradiation and some methods of pathogen inactivation (i.e. Intercept and Mirasol systems) [24,25]. At present, we record sporadic use of only irradiation of RBCs and PCs.…”