Study of Calcitonin and Thyroglobulin Gene Expression in Human Mixed Follicular and Medullary Thyroid Carcinoma

Noël, Michèle; Delehaye, M.C.; Segond, N.; Lasmoles, F.; Caillou, Bernard; Gardet, P; Fragu, P.; Moukhtar, M.S.

doi:10.1089/thy.1991.1.249

Cited by 31 publications

(23 citation statements)

References 30 publications

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“…Co-expression of CT and TG by the same cell was found by Ljiungberg and Nilsson [29] by double immunostaining of cases of intermediate carcinoma. Because of the possibility of passive absorption, TG mRNA detection provided a more specific demonstration of follicular differentiation [37]. However these authors did not investigate the expression of both CT and TG in the same neoplastic cell.…”

Section: Discussionmentioning

confidence: 99%

Mixed medullary-follicular carcinoma of the thyroid

et al. 1997

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Mixed medullary-follicular carcinomas (MMFC) of the thyroid are rare tumours showing the morphological and immunochemical properties of both parafollicular and follicular cell lineages. Their recognition is based on a classical WHO definition, although several other patterns have been described in recent years. We investigated 11 cases of MMFC by immunohistochemistry and in situ hybridization (ISH) to analyse the structural features, the immunophenotypic profile and the calcitonin (CT) and thyroglobulin (TG) gene expression of the neoplasm. Histologically, 10 cases had mixed parafollicular and follicular cell populations in the primary tumour and 1 only in the lymph node metastasis. All cases were immunoreactive for CT (in medullary areas) and TG (in follicular areas and also in the solid component of 8/11 cases). These findings were confirmed by ISH analysis. Combined ISH and immunostaining showed that most cases had separate CT and TG gene expression, although rare cells with concurrent CT and TG gene expression were identified in 2 tumours. We conclude that (a) MMFC display heterogeneous morphological patterns and are a special type of thyroid tumour undergoing divergent differentiation; (b) in MMFC, CT and TG genes are generally not simultaneously expressed by the same cell, although dual expression of CT and TG was present in rare neoplastic elements; and (c) the origin of MMFC, whether they are derived from the ultimo-branchial body or result from neoplastic transformation of different cell populations following common oncogenic stimuli, is unclear.

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Section: Discussionmentioning

confidence: 99%

Mixed medullary-follicular carcinoma of the thyroid

et al. 1997

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“…(9,10) Another possible hypothesis is that a common oncogenic stimulus leads to the simultaneous transformation of both follicular and C-cell progenitor stem cells, and thus the formation of both medullary and follicular compounds.…”

Section: A 1bmentioning

confidence: 99%

Simultaneous medullary carcinoma, papillary carcinoma and granulomatous inflammation of the thyroid

Kataria¹,

Yadav²,

Sarkar³

et al. 2013

smedj

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We report a case of a collision tumour occurring in the right thyroid lobe. The collision tumour had lesions with features of MTC and PTC at two different locations that were separated by normal thyroid tissue. In addition, a separate focus of papillary carcinoma in the left thyroid lobe, C-cell hyperplasia with granulomatous inflammation in the right thyroid lobe and metastasis of the medullary component to the right neck lymph nodes were also seen. To the best of our knowledge, this is the first report of such a combination of features. CA S E R E PO RTA 35-year-old man presented with complaints of a slowgrowing left thyroid swelling that had persisted for six months. He had no symptoms of hypo-or hyperthyroidism, dysphagia, voice change, abdominal pain, irradiation in the head and neck region, or a family history of thyroid cancer.He had a history of pulmonary tuberculosis one year before presentation.Examination revealed a small, firm-to-hard, non-tender ABSTRACT Thyroid tumours with both papillary and medullary carcinoma features are rare and represent less than 1% of all thyroid malignancies. These tumours have a different clinical presentation and biological behaviour from tumours that have only papillary or medullary carcinoma features. The phenomenon of mixed thyroid tumours can be observed in two settings -a mixed tumour showing dual differentiation, or a collision tumour. For a precise diagnosis of this rare mixed thyroid carcinoma, fine needle aspiration cytology results should be correlated with serum calcitonin and thyroglobulin levels. The diagnosis should also be confirmed using immunocytochemistry. Surgery is the treatment of choice, and the role of postoperative radioiodine is controversial. We herein report the case of a 35-year-old man with a mixed medullary-papillary carcinoma of the thyroid, which presented with C-cell hyperplasia, granulomatous inflammation and metastasis to the cervical lymph nodes. The patient was treated with total thyroidectomy and nodal clearance. This case highlights the need for awareness of coexistent entities as they warrant separate treatments.

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“…MMFC are very rare tumors, accounting for less than 0.2% of all thyroid tumors [34,56]. As for conventional medullary carcinoma, MMFC may arise as sporadic tumors, in the vast majority of reported cases, or associated with MEN2 syndrome [38,43,47,55], both type 2A and type 2B. MMFC is an extremely heterogeneous group of tumors in terms of morphological features.…”

Section: Meec In the Pancreas Gastrointestinal And Biliary Tractmentioning

confidence: 99%

Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms

et al. 2007

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Within the spectrum of neuroendocrine tumors arising in different organs, intermediate and controversial entities exist displaying a coexistence of neuroendocrine and nonneuroendocrine cell populations, and that are grouped under terms such as "goblet cell carcinoid", "mixed endocrine-exocrine carcinoma", "combined carcinomas", or "adenocarcinoma with neuroendocrine differentiation". These tumors may display variable amounts of the two components, potentially ranging from 1 to 99%, and variable structural patterns, ranging from single scattered neuroendocrine cells to a well-defined neuroendocrine tumor cell component organized in typical organoid, trabecular, or solid growth patterns. Although variably included in the site-specific World Health Organization classification schemes, clear definitions and diagnostic features are still missing, as well as a definite knowledge of their biological properties and histogenesis. In the present report, the main characteristics of tumors showing mixed neuroendocrine and nonneuroendocrine features will be described, using morphological patterns and site of origin as schematic guidelines. Moreover, molecular and clinical aspects, which might help to understand their possible histogenesis and biological behavior, will be reviewed.

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Study of Calcitonin and Thyroglobulin Gene Expression in Human Mixed Follicular and Medullary Thyroid Carcinoma

Cited by 31 publications

References 30 publications

Mixed medullary-follicular carcinoma of the thyroid

Mixed medullary-follicular carcinoma of the thyroid

Simultaneous medullary carcinoma, papillary carcinoma and granulomatous inflammation of the thyroid

Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms

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