Study of C-Reactive Protein and Myocardial Infarction in the Indian Population

Shalia, Kavita; Savant, Sudha S.; Haldankar, V. A.; Nandu, Tulip; Pawar, Poonam; Divekar, Siddhi; Shah, Vinod K.; Bhatt, Purvi

doi:10.1007/s12291-011-0164-9

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…We finally were left with 16 studies. 14 , 15 , 18 – 20 , 28 – 38 As shown in Table 1 , 9 studies from the USA, Italy, Croatia, Germany, Iran, Egypt, or India were categorized as Caucasians and the remainders consisting of 7 Asian studies were all conducted in Chinese subjects. There were 14 case–control studies for +942G C, 5 for −717A G, and 3 for +1444C T. The Asian studies had a relatively smaller sample size compared with the Caucasian studies.…”

Section: Resultsmentioning

confidence: 99%

Genetic Association Studies Reporting on Variants in the C-Reactive Protein Gene and Coronary Artery Disease

Shi

Zhang²,

Tan³

et al. 2015

Medicine

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C-reactive protein (CRP) is a commonly used inflammatory marker and elevated CRP levels are shown to increase the risk of coronary artery disease (CAD). Sequence variations in the CRP gene believed to influence the protein levels have been extensively investigated in CAD community. Most of the published studies, however, have reported mixed findings. The objective of the present study was to examine the associations of CRP variants (+942GC, −717AG, +1444CT) with genetic risk of CAD by use of a meta-analysis.The human case–control studies were identified through online search, hand search, and contacting the authors of original articles. We performed both random-effect and fixed-effect meta-analysis to estimate CAD risk (odds ratios, OR). This analysis combined 16 studies in total. We found +942GC was not associated with CAD risk when all data were pooled together, nor did we find a significant association in subgroup analyses. Meta-analysis of +1444CT studies showed a similar trend. However, a borderline association with CAD risk was revealed for −717AG (random-effect: OR = 0.53, 95% CI = 0.28–1.00 for the homozygous model; random-effect: OR = 0.51, 95% CI = 0.26–1.00 for the recessive model).These data suggest that the CRP gene variants examined may not modulate CAD risk.

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Section: Resultsmentioning

confidence: 99%

Genetic Association Studies Reporting on Variants in the C-Reactive Protein Gene and Coronary Artery Disease

Shi

Zhang²,

Tan³

et al. 2015

Medicine

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“…The HDL-C particle is believed to be anti-atherogenic and antagonized pathways of inflammation, thrombosis, and oxidation. [9][10][11][12][13] Unlike to male with myocardial infarction the mean serum levels of LDL-C were significantly higher (P <0.05) in the female with myocardial infarction compared to the control. Studies have shown that the levels of LDL-C were associated with atherosclerosis.…”

Section: Serum Low-density Lipoprotein (Ldl-c)mentioning

confidence: 99%

Evaluation of serum C-reactive protein and lipid profile in patients with myocardial infarction

Abbass

2018

Zanco J Med Sci

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“…C-reactive protein (CRP), a marker of systemic inflammation and synthesized in liver, has been received considering attention in aging mediated inflammatory disorders such as CVD, osteoarthritis and cancer etc. [3][4][5]. Previous studies have demonstrated an association between age related disorders and inflammation as measured by plasma C-reactive protein Original Research Article [6,7].…”

Section: Introductionmentioning

confidence: 99%

Relation of senescence with systemic inflammation and serum paraoxanase activity: A clinical approach

Sharma¹,

Saxena²,

Shaida³

et al. 2016

SJAMS

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It has been documented that the incidence of inflammation along with oxidative stress in biological system leads to the development of age related complications. However, the mechanism exploring the conundrum of senescence with various sorts of health complications is still in obscure. Therefore, the present study was designed to evaluate the relation of serum paraoxonase (PON) with markers of systemic inflammation and lipid peroxidation in the blood samples of different age group subjects and to determine their relation in the prediction of cardiovascular disease risk. Marker of lipid peroxidation (malondialdehyde; MDA), serum paraoxonase, c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were estimated in selected 90 healthy subjects by using standard methods. Out of 90 subjects, 60 individuals were categorized into two groups: Group I (40-55 years) and Group II (≥ 56 years) and statistically compared it with that of 30 younger controls (20-30 years). Marked depletion in serum PON activity was observed in Group I and II as compared to healthy controls whereas erythrocyte MDA levels were increased significantly (p<0.05) in Group I and II subjects. However, serum CRP levels were increased significantly (p<0.05) only in Group II subjects whereas ESR levels were altered insignificantly (p<0.01) in Group I and II subjects as compare to controls. In addition, PON activity was inversely correlated with marker of systemic inflammation and lipid peroxidation. Thus, assessment of serum paraoxonase activity incorporation with marker of systemic inflammation is a crucial step in early diagnosis of cardiovascular complications in elderly. Therefore, regular monitoring of cardiac markers and antioxidant rich diet should be adopted with senescence.

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Study of C-Reactive Protein and Myocardial Infarction in the Indian Population

Cited by 7 publications

References 39 publications

Genetic Association Studies Reporting on Variants in the C-Reactive Protein Gene and Coronary Artery Disease

Genetic Association Studies Reporting on Variants in the C-Reactive Protein Gene and Coronary Artery Disease

Evaluation of serum C-reactive protein and lipid profile in patients with myocardial infarction

Relation of senescence with systemic inflammation and serum paraoxanase activity: A clinical approach

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