Study of C - reactive protein in neonatal sepsis

Abstract

Background: Sepsis is one of the most common causes of morbidity and mortality in the newborn. Early diagnosis and treatment is vital to improve outcome. Neonatal sepsis in newborn is characterized by paucity of signs and symptoms and is due to invasion and spread through the body of non-pathogenic/ pathogenic & Gram positive / negative organism. It is subtle disease, the general characteristic of bacterial infection in neonatal period are influenced more by response of the infant than the causative organism. The present study was therefore carried out to determine the usefulness of C-reactive protein (CRP) for evaluation of neonatal sepsis in tertiary care hospital.Methods: Neonates with clinical suspicion of sepsis were prospectively studied out from June 2006 to January 2008. Blood was obtained from each subject recruited for the qualitative estimation of CRP. Blood culture was used as gold standard for diagnosis of NNS.Results: Of 50 neonates studied, 34 (68%) had positive CRP while 31 (62%) had positive blood culture. The sensitivity, specificity, positive and negative predictive values of CRP were 90.32%, 42.10%, 71.79% and 72.72% respectively.Conclusions: The qualitative method of estimating CRP which is cheap and rapid has moderate sensitivity, specificity and negative predictive value.

Evaluation of C-Reactive Protein (CRP) in Early Diagnosis of Neonatal Septicemia

“…Gram negative organisms formed the majority of the isolates as compared to Gram positive organisms (65% vs 35% respectively) in the present study. Klebsiella pneumoniae (41%) was the predominant isolate, which correlates with study of Twinkle N Gandhi et al, (2,13). The causative organisms of neonatal sepsis vary with time and place.…”

Study of association of C-reactive protein with maternal chorioamnionitis and early-onset neonatal sepsis in premature rupture of membranes deliveries: A diagnostic dilemma

“…Mehrotra reported a study in 2017 to determine the usefulness of CRP for evaluation of neonatal sepsis in tertiary care hospital. [11] He studied on 50 neonates and reported that 34 (68%) had positive CRP while 31 (62%) had positive blood culture. The sensitivity, specificity, PPV, and NPV of CRP were 90.32%, 42.10%, 71.79%, and 72.72%, respectively.…”