Study of blood groups, abnormal hemoglobins and other genetical characters in some tribes of Gujarat

Vyas, Girish N.; Bhatia, H. M.; Sukumaran, P. K.; Balkrishnan, V.; Sanghvi, L. D.

doi:10.1002/ajpa.1330200310

Cited by 27 publications

(12 citation statements)

References 8 publications

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“…Several studies in the literature have reported that Gujarat has higher frequency of β-thalassemia and sickle cell disease. [34910] Therefore prospective studies are essential to identify high risk communities. Premarital screening of college students not only gives prevalence in different caste groups but also helps in counseling and prenatal diagnosis programs for prevention of birth of an affected child.…”

Section: Discussionmentioning

confidence: 99%

Hemoglobinopathies in South Gujarat population and incidence of anemia in them

et al. 2012

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OBJECTIVE:To Screen of South Gujarat population for determination of prevalence of different hemoglobinopathies particularly beta thalassemia trait (BTT) and sickle cell trait (SCT) and find out the incidence of anemia in them.MATERIAL AND METHODS:The present study screened 32,857 samples of students from different school and colleges in South Gujarat. Blood samples were initially tested for solubility test and complete hemogram on hematology analyzer. Samples having MCV (≤78), MCH (≤28) and/or positive solubility test were investigated for Hb electrophoresis on cellulose acetate membrane (pH 8.6). Hb A2 level ≥3.5% was considered as diagnostic for BTT. High performance liquid chromatography on Biorad Hb variant system was done on samples having doubtful results.RESULT:Overall prevalence of BTT and SCT in South Gujarat was 4.4% and 1.3% respectively. Gamit, Vasava, Chaudhary, and Mahyavanshi castes had high prevalence of BTT (15.9%, 13.6%, 12.6%, and 6.9%) as well as SCT (22.2%, 15.2, 22.3, and 4.2%) respectively. Other communities like Lohana (10.8%), Sindhi (10.2%), Prajapati (6.3%), and Ghanchi (6.2%) also showed higher prevalence of BTT. Incidence of mild to moderate anemia was higher in BTT and SCT compared to non-BTT or non-SCT subjects.CONCLUSIONStudy suggests that BTT is the most prevalent hemoglobinopathy in South Gujarat. β-thalassemia and Sickle cell anemia are highly prevalent in Mahyavanshi, Chaudhary, Gamit, Vasava and Rohit. Prajapati, Lohana, Leva Patel, and Ghanchi have β- thalassemia risk. SCT is more frequently detected in Dhodia Patel and Kukanas.

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Section: Discussionmentioning

confidence: 99%

Hemoglobinopathies in South Gujarat population and incidence of anemia in them

et al. 2012

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“…One of the reasons may be cooccurrence of ~-thalassemia along with HbS which reduces the lethality of HbS, and increased level of HbF among the HbS heterozygous or homozygous individuals. High frequencies (about 16 ~) of S allele have been reported amongst the Gamit of Gujrat, Western India (Vyas et al, 1962) and in the Bhilala tribes of Madhya Pradesh (ICMR report, 1986); about 13 ~ in the Konda Paroja or Orissa (Das et al, 1967), and in South India it is also high (about 18 ~) amongst the Pradhan of Andhra Pradesh (Blake et al, 1981).…”

Section: G-6-pd Deficiencymentioning

confidence: 99%

Study of enzyme polymorphism and haemoglobin patterns amongst sixteen tribal populations of central India (Orissa, Madhya Pradesh, and Maharashtra)

et al. 1993

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SummaryA survey was conducted to study the genetic differentiation among 16 tribal groups of Orissa, Madhya Pradesh, and Maharashtra belonging to different ethnic and linguistic affiliations. Sixteen hundred and fifteen blood samples from both sexes were tested for 5 red cell enzyme systems: ACP, ESD, PGD, GLO, LDH, and Hb pattern. Three hundred and nineteen male individuals were tested for G-6-PD enzyme deficiency. The distribution of the enzyme markers and Hb show a range of variation which are more or less within the Indian range. Cases of homozygous HbSS were detected in all the tribes except 3 tribes in Orissa. Two cases of LDH Cal-I homozygote were found in two Dravidian language speaking Orissa tribes. The Z2-values for testing the homogeneity of gene frequencies indicate a non-significant heterogeneity for all alleles in the individual system. Within population diversity seems to be larger than between population diversity. The degree of over all genetic differentiation as measured by Gs~ value is 0.0154+0.0071.

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“…Except for Western India, very little is, however, known about the blood group frequencies in different caste groups. In Western India detailed studies on various endogamous groups have been made by Sanghvi and Khanolkar [1949], Vyas et al [1958Vyas et al [ , 1962 and Varde [1958], The present paper gives the ABO and Rh sub-types of the North Indian populations of U.P., Punjab and Delhi residing in and around Delhi area. …”

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confidence: 99%