Study of Biological Behavior and Antimicrobial Properties of Cerium Oxide Nanoparticles

Chatzimentor, Iason; Tsamesidis, Ioannis; Ioannou, Maria-Eleni; Pouroutzidou, Georgia K.; Beketova, Anastasia; Giourieva, Veronica; Papi, Rigini; Kontonasaki, Eleana

doi:10.3390/pharmaceutics15102509

Cited by 6 publications

(2 citation statements)

References 58 publications

(72 reference statements)

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“…This results in a redox couple which is the reason for nanoceria’s catalytic activity. This has led to an increased interest in Nanoceria as a potential biological antioxidant [ 133 – 140 ]. Because of the lattice structure and ease of electronic conversions with other ionic species at the quantum level, CeO 2 NPs are capable of regenerating their redox-active matrix, allowing repetitive free radical interactions [ 141 ].…”

Section: Inorganic and Organic Nanoparticlesmentioning

confidence: 99%

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Unnikrishnan,

Joy,

Megha

et al. 2023

Discover Nano

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The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles are stable, have a wide range of physicochemical, mechanical, magnetic, and optical characteristics, and also have the capability to get modified using some ligands to enrich their attraction towards the molecules at the target site, which makes them appealing for bio-imaging and drug delivery applications. One of the strong benefits of using the inorganic nanoparticles-drug conjugate is the possibility of delivering the drugs to the affected cells locally, thus reducing the side-effects like cytotoxicity, and facilitating a higher efficacy of the therapeutic drug. This review features the direct and indirect effects of such inorganic nanoparticles like gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, and CeO2 nanoparticles in developing effective drug carrier systems. This article has remarked the peculiarities of these nanoparticle-based systems in pulmonary, ocular, wound healing, and antibacterial drug deliveries as well as in delivering drugs across Blood–Brain-Barrier (BBB) and acting as agents for cancer theranostics. Additionally, the article sheds light on the plausible modifications that can be carried out on the inorganic nanoparticles, from a researcher’s perspective, which could open a new pathway. Graphical abstract

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Section: Inorganic and Organic Nanoparticlesmentioning

confidence: 99%

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Unnikrishnan,

Joy,

Megha

et al. 2023

Discover Nano

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show abstract

“…Furthermore, research has demonstrated that CNZs possess potential antimicrobial capabilities, attributed to their ability to disrupt the charge profile of bacterial cell surfaces. This characteristic confers CNZs with broad-spectrum antimicrobial properties [ 8 ]. However, it is worth noting that oxidative stress is only one of the factors contributing to disease, and nanozymes may be more suited to a supporting role [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival

Ju,

Yang,

Liu

et al. 2024

Biomater Res

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Random flap grafting is a routine procedure used in plastic and reconstructive surgery to repair and reconstruct large tissue defects. Flap necrosis is primarily caused by ischemia–reperfusion injury and inadequate blood supply to the distal flap. Ischemia–reperfusion injury leads to the production of excessive reactive oxygen species, creating a pathological microenvironment that impairs cellular function and angiogenesis. In this study, we developed a microenvironment remodeling self-healing hydrogel [laminarin–chitosan-based hydrogel-loaded extracellular vesicles and ceria nanozymes (LCH@EVs&CNZs)] to improve the flap microenvironment and synergistically promote flap regeneration and survival. The natural self-healing hydrogel (LCH) was created by the oxidation laminarin and carboxymethylated chitosan via a Schiff base reaction. We loaded this hydrogel with CNZs and EVs. CNZs are a class of nanomaterials with enzymatic activity known for their strong scavenging capacity for reactive oxygen species, thus alleviating oxidative stress. EVs are cell-secreted vesicular structures containing thousands of bioactive substances that can promote cell proliferation, migration, differentiation, and angiogenesis. The constructed LCH@EVs&CNZs demonstrated a robust capacity for scavenging excess reactive oxygen species, thereby conferring cellular protection in oxidative stress environments. Moreover, these constructs notably enhance cell migration and angiogenesis. Our results demonstrate that LCH@EVs&CNZs effectively remodel the pathological skin flap microenvironment and marked improve flap survival. This approach introduces a new therapeutic strategy combining microenvironmental remodeling with EV therapy, which holds promise for promoting flap survival.

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Controlled Release of Ceria and Ferric Oxide Nanoparticles via Collagen Hydrogel for Enhanced Osteoarthritis Therapy

Chen,

Wang,

Zhang

et al. 2024

Adv Healthcare Materials

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Osteoarthritis (OA), characterized by chronic inflammation and cartilage degeneration, significantly affects over 500 million people globally. Nanoparticles have emerged as promising treatments for OA; however, current strategies often employ a single type of nanoparticle targeting specific disease stages, limiting sustained therapeutic efficacy. In this study, a novel collagen hydrogel is introduced, thiol crosslinked collagen‐cerium oxide‐poly(D,L‐lactic‐co‐glycolic acid) microspheres encapsulating nanoparticles (CSH‐CeO2‐pFe2O3), designed for the controlled release of cerium oxide (CeO2) and ferric oxide (Fe2O3) nanoparticles for comprehensive OA management. The sulfhydryl cross‐linked collagen matrix embeds CeO2 nanoparticles and poly(D,L‐lactic‐co‐glycolic acid) (PLGA) microspheres encapsulating Fe2O3 nanoparticles. The CSH‐CeO2‐pFe2O3 hydrogel exhibits enhanced mechanical strength and remarkable injectability, along with a significant promotion of cell adhesion, proliferation, and chondrogenic differentiation. Notably, the hydrogel demonstrates intelligent responsiveness to high levels of reactive oxygen species, initiating the rapid release of CeO2 nanoparticles to address the intense inflammatory responses of early‐stage OA, followed by the sustained release of Fe2O3 nanoparticles to facilitate cartilage regeneration during the proliferative phase. In a rat model with cartilage defects, the hydrogel significantly alleviates inflammation and enhances cartilage regeneration, holding substantial potential for effectively managing the pathologically complex OA.

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Study of Biological Behavior and Antimicrobial Properties of Cerium Oxide Nanoparticles

Cited by 6 publications

References 58 publications

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Microenvironment Remodeling Self-Healing Hydrogel for Promoting Flap Survival

Controlled Release of Ceria and Ferric Oxide Nanoparticles via Collagen Hydrogel for Enhanced Osteoarthritis Therapy

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