Study of association between interleukin-8 − 845 T/C and + 781 C/T polymorphisms with periodontitis disease among population from Western Iran

Sajadi, Mehdi; Shahmohammadi, Azin; Mahmazi, Sanaz; Bashiri, Hoda; Bavandpour, Mehrdad; Yari, Kheirollah

doi:10.1007/s11033-018-4282-9

Cited by 7 publications

(9 citation statements)

References 35 publications

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“…This is also consistent with the pro-osteoclastogenic activity of IL-6 [44] and the overall chemoattractant effects of IL-8 [45]. Nevertheless, although certain haplotypes of the IL-8 gene have been shown to significantly associate with susceptibility to chronic periodontitis [46,47], there remain contradictory reports on IL-8 levels in the gingival crevicular fluid of healthy and chronic periodontitis patients [48][49][50][51]. Furthermore, even if IL-8 levels may be relevant markers of chronic periodontitis, this does not entail that they are the most relevant targets for an anti-inflammatory strategy, which should mostly focus on blocking the farthest-reaching mediators, those biomolecules that are likely to control important down-stream effectors.…”

Section: Establishing a Traditionsupporting

confidence: 75%

Between Innovation and Standardization, Is There Still a Room for Scientific Reports? The Rise of a Formatting Tradition in Periodontal Research

et al. 2019

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Everybody, regardless of their role, is aware that biomedical research is rapidly evolving, and the demand for reproducibility is increasing together with the amount of novel information. “Before reproducibility must come pre-producibility” “Checklists work to improve science”, just to quote some of the articles querying how to find a new bridge between ethics in science and the urgency for publishing. Looking for papers on anti-inflammatory compounds in periodontics, we came across a significant number of articles that could be considered a prototype of a consistent study format. The literature on the testing of active compounds on lipopolysaccharides- (LPS)-induced inflammation in gingival fibroblasts was searched to identify studies that followed a consistent format, to better understand their similarities and assess the appropriateness of their methods. Several studies were identified with a degree of similarity in their methods and formatting that was so high that it was possible to rule out that it was due to chance, and a format template common to these studies was outlined. Although this was most likely beyond the intentions of their authors, these studies may pose the basis for an in-vitro testing standard for anti-inflammatory compounds; however, the dangers of acritical uniformity are also apparent.

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Section: Establishing a Traditionsupporting

confidence: 75%

Between Innovation and Standardization, Is There Still a Room for Scientific Reports? The Rise of a Formatting Tradition in Periodontal Research

et al. 2019

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“…Two studies were done with periodontitis affected patients, analysing IL-8 polymorphisms association with the disease 16,19 . Two studies analysed periodontitis and type 1 or 2 diabetes mellitus association with IL-8 polymorphisms along with patients affected by periodontal pathologies 17,18 .…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

“…CXCR1 and CXCR2 genes and their polymorphisms were reported by four studies 18,24,36,39 . Twenty-two studies focused on IL-8 polymorphisms and their different variants findings 12,[17][18][19][20][21][22][23][25][26][27][28][30][31][32][33]37,40,41,[43][44][45] .…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Periodontitis association with IL-8 gene polymorphisms

Kriaučiūnas

Žekonis

Liutkevičienė

2022

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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IL-8 and its polymorphisms are involved in multiple acute and chronic inflammatory processes including pathological changes to surrounding structures of the teeth called periodontal diseases or periodontitis. The aim of this manuscript was to systematically review studies from 2006 to 2021 on IL-8 polymorphisms and their association with periodontitis. Literature analysis was done following the PRISMA protocol guidance using articles not older than 15 years (2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018)(2019)(2020)(2021). The search was carried out using PubMed (MEDLINE), ScienceDirect and Wiley Online Library databases. For the focus question, the PICO (population (P), intervention (I), control (C), and outcome (O)) study design protocol was used, and the following question was formulated: are IL-8 gene polymorphisms associated with periodontitis? A total of 2422 articles were found at the beginning of the search. After applying the inclusion and exclusion criteria, screening, and full-text article exclusion with reasons, 31 studies were included in the analysis. In conclusion, IL-8 and its gene polymorphisms are associated with an increased risk of periodontal diseases.

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“…This cytokine activates the migration of neutrophils in inflammatory regions [68]. The IL-8 gene is located on chromosome 4q13-q21 [46,88]. Previous studies have shown the association of IL-8 SNPs with PD [45].…”

Section: Interleukinmentioning

confidence: 99%

Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease

Kozak

Dąbrowska-Żamojcin

Mazurek−Mochol

et al. 2020

JCM

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Periodontal disease (PD) is a chronic inflammatory disease caused by the accumulation of bacterial plaque biofilm on the teeth and the host immune responses. PD pathogenesis is complex and includes genetic, environmental, and autoimmune factors. Numerous studies have suggested that the connection of genetic and environmental factors induces the disease process leading to a response by both T cells and B cells and the increased synthesis of pro-inflammatory mediators such as cytokines. Many studies have shown that pro-inflammatory cytokines play a significant role in the pathogenesis of PD. The studies have also indicated that single nucleotide polymorphisms (SNPs) in cytokine genes may be associated with risk and severity of PD. In this narrative review, we discuss the role of selected cytokines and their gene polymorphisms in the pathogenesis of periodontal disease.

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Study of association between interleukin-8 − 845 T/C and + 781 C/T polymorphisms with periodontitis disease among population from Western Iran

Cited by 7 publications

References 35 publications

Between Innovation and Standardization, Is There Still a Room for Scientific Reports? The Rise of a Formatting Tradition in Periodontal Research

Between Innovation and Standardization, Is There Still a Room for Scientific Reports? The Rise of a Formatting Tradition in Periodontal Research

Periodontitis association with IL-8 gene polymorphisms

Cytokines and Their Genetic Polymorphisms Related to Periodontal Disease

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