Study of ascorbic acid interaction with hydroxypropyl-β-cyclodextrin and triethanolamine, separately and in combination

Garnero, Claudia; Longhi, Marcela R.

doi:10.1016/j.jpba.2007.07.030

Cited by 62 publications

(29 citation statements)

References 24 publications

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“…Studies show that CD has minor effect on the degradation of ascorbic acid, and the inclusion of ascorbic acid into the CD cavity is negligible (35). Stability of collagen has been studied, and results show that blending collagen with PVA increases the thermal and photochemical stability of collagen (36).…”

Section: Ftir Studiesmentioning

confidence: 99%

Novel Vitamin and Gold-Loaded Nanofiber Facial Mask for Topical Delivery

et al. 2010

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Abstract. L-ascorbic acid has been widely used in cosmetic and dermatological products because of its ability to scavenge free radicals and destroy oxidizing agents. However, it is chemically unstable and can easily be oxidized. The current cosmetic facial masks available in the market are pre-moistened, which means that the aqueous fluid content of the mask may oxidize some of the unstable active ingredients such as ascorbic acid. This work presents an anti-wrinkle nanofiber face mask containing ascorbic acid, retinoic acid, gold nanoparticles, and collagen. This novel face mask will only be wetted when applied to the skin, thus enhancing product stability. Once moistened, the content of the mask will gradually dissolve and release the active ingredients and ensure maximum skin penetration. The high surface areato-volume ratio of the nanofiber mask will ensure maximum contact with the skin surface and help to enhance the skin permeation to restore its healthy appearance. Electrospun fiber mats may provide an attractive alternative to the commercial facial cotton masks.

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Section: Ftir Studiesmentioning

confidence: 99%

Novel Vitamin and Gold-Loaded Nanofiber Facial Mask for Topical Delivery

et al. 2010

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“…The effects of degree of substitution and of pH on complex formation between HP-α-CD and HP-β-CD with ascorbic acid have been also investigated [7]. The interaction of ascorbic acid with HP-β-CD was also investigated by FTIR, 1 H NMR and UV spectroscopy [8]. 1 H NMR study of α-and β-CD complexation with ascorbic acid was performed to establish the protons of α-or β-CD involved in the inclusion process [9].…”

Section: Related Contentmentioning

confidence: 99%

Spectroscopic investigation of the interaction between β-cyclodextrin and ascorbic acid

Bratu¹,

Mureşan-Pop²,

Kacsó³

et al. 2009

J. Phys.: Conf. Ser.

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“…Therefore, it is clear that max should be determined for each solution, because spectrophotometric readings for only one (as recommended in several works) can produce imprecise data. Nevertheless, the results obtained in our previous study demonstrated that complexation with HP-␤-CD and TEA, either separately or in combination, increases not only the stability of ascorbic acid but also the value of max [13]. An important implication of maintaining the value of max is that it permits the development of reliable analytical methods for stability studies and quality control of pharmaceutical products containing ascorbic acid.…”

Section: Spectrophotometric Methodsmentioning

confidence: 87%

“…The results obtained showed a pronounced enhancement of aqueous stability with the TEA association complex, whereas the HP-␤-CD inclusion complex had a minor effect. In addition, the multicomponent complex produced a significantly better stabilization than that of HP-␤-CD alone [13].…”

Section: Introductionmentioning

confidence: 91%