Study of Apoptosis Induced by <sup>188</sup>Re-DTPA-DG in MCF-7 Breast Carcinoma and A549 Pulmonary Carcinoma Cells

Xiong, Qing-Feng; Chen, Yue; He, Ling; Deng, Chuiwen; Huang, Zhanwen; Ju-lian, LI

doi:10.1089/cbr.2007.367a

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…A previous study showed that 188 Re-DTPA-DG had an apoptotic effect on carcinoma cells. 26 Both 188 Re and 177 Lu can emit c photons for imaging and b --particles for therapy, but the characteristics of these radionuclides are different. 188 Re is obtained from a 188 W/ 188 Re generator in clinical settings and has a half-life of 0.7083 d, with a complicated decay mechanism.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Studies of ¹⁷⁷Lu-Diethylenetriamine Penta-Acetic Acid-Deoxyglucose in Hepatic Tumor-Bearing Mice

Zhou

Chen

Yang

et al. 2020

Cancer Biotherapy and Radiopharmaceuticals

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Objective: The purpose of this study was to explore the potential use of 177 Lu-diethylenetriamine penta-acetic acid-deoxyglucose (177 Lu-DTPA-DG) as a radiopharmaceutical for hepatic tumor treatment. Methods: Lutetium-177 (177 Lu) was labeled with DTPA-DG by adding 2 mCi 177 LuCl 3 to 0.05 mg DTPA-DG (pH 5-6) at room temperature for 1 h. The quality of the 177 Lu-DTPA-DG solutions was determined by thinlayer chromatography and high-performance liquid chromatography. Cellular uptake studies with 18 Ffluorodeoxyglucose (FDG), 177 Lu-DTPA-DG and 177 Lu-DTPA and a blocking study with 1.0 mg d-glucose were performed. Biodistribution, imaging, and radiotherapy studies of 177 Lu-DTPA-DG were performed with the SMMC-7721 model. Results: 177 Lu-DTPA-DG had a high radiochemical purity (>97%). The cellular uptake of 177 Lu-DTPA-DG was much higher than that of the 177 Lu-DTPA. The biodistribution of 177 Lu-DTPA-DG demonstrated that the complex accumulated in the tumor with high tumor/blood and tumor/muscle ratios. The tumors in mice in the 177 Lu-DTPA-DG group clearly displayed the high uptake of 177 Lu-DTPA-DG. After radiotherapy with 177 Lu-DTPA-DG, tumor growth decreased, and the overall survival was longer than that in the 177 LuCl 3 group (268.58-17.96 mm 3 vs. 507.43-55.72 mm 3 , p = 0.002) and the normal saline group (268.58-17.96 mm 3 vs. 483.68-27.51 mm 3 , p < 0.05). Conclusions: This preliminary study suggests that 177 Lu-DTPA-DG has the potential to become a liver radiopharmaceutical agent and should be further investigated.

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Section: Discussionmentioning

confidence: 99%

Preliminary Studies of ¹⁷⁷Lu-Diethylenetriamine Penta-Acetic Acid-Deoxyglucose in Hepatic Tumor-Bearing Mice

Zhou

Chen

Yang

et al. 2020

Cancer Biotherapy and Radiopharmaceuticals

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“…They are MAG-3-glucosamine [53], DTPA-glucosamine [54][55][56][57][58], and ECglucosamine (EC-G) [59][60][61]. The structures are shown in Fig.…”

Section: Radiolabeled Glucosamine Analogues As Alternative Chelator-bmentioning

confidence: 99%

“…However, there were neither a tumor model nor human studies to affirm the effectivenss of MAG-3-glucosmaine. Although, DTPA-glucosamine was labeled with 99m Tc and 188 Re, respectively [54][55][56][57][58], it exhibited a faster clearance in animal studies, thus, the tumor registration was low. Again, it has been discovered that radiolabeled EC-G behaves, in certain respects, quite differently than radiolabeded FDG.…”

Section: Radiolabeled Glucosamine Analogues As Alternative Chelator-bmentioning

confidence: 99%

Molecular Imaging Kits for Hexosamine Biosynthetic Pathway in Oncology

Yang

Kong²,

Oka³

et al. 2012

curr med chem

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Noninvasive imaging assessment of tumor cell proliferation could be helpful in the evaluation of tumor growth potential, the degree of malignancy, and could provide an early assessment of treatment response prior to changes in tumor size determined by computed tomography (CT), magnetic resonance imaging (MRI), Positron emission tomography (PET), Single-Photon emission computed tomography (SPECT) or ultrasonography, respectfully. Understanding of tumor proliferative activity, in turn, could aid in the selection of optimal therapy by estimating patient prognosis and selecting the proper management. PET/CT imaging of (18)F-fluoro-2-deoxy-glucose (FDG) is recognized as a technology for diagnosing the presence and extent of several cancer types. Recently, radiolabeled glucosamine analogues were introduced as a promising SPECT agent to complement FDG imaging to increase specificity and improve the accuracy of lesion size in oncology applications. Radiolabeled glucosamine analogues were developed to localize in the nuclear components of cells primarily via the hexosamine biosynthetic pathway whereas glucose localizes in the cytoplasm of cells through the glycolytic/TCA pathway. This paper reviews novel kit-based radiolabeled glucosamine analogues for metabolic imaging of tumor lesions. The novel radiolabeled glucosamine analogues may increase the specificity in oncology applications and can influence patient diagnosis, planning and monitoring of cancer treatment.

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18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review)

2016

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Study of Apoptosis Induced by ¹⁸⁸Re-DTPA-DG in MCF-7 Breast Carcinoma and A549 Pulmonary Carcinoma Cells

Abstract: 188Re-DTPA-DG has a significant apoptotic effect on carcinoma cells. 188Re-DTPA-DG is an effective radiopharmaceutical for intratumoral radiation therapy.

Cited by 6 publications

References 11 publications

Preliminary Studies of ¹⁷⁷Lu-Diethylenetriamine Penta-Acetic Acid-Deoxyglucose in Hepatic Tumor-Bearing Mice

Preliminary Studies of ¹⁷⁷Lu-Diethylenetriamine Penta-Acetic Acid-Deoxyglucose in Hepatic Tumor-Bearing Mice

Molecular Imaging Kits for Hexosamine Biosynthetic Pathway in Oncology

18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review)

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Study of Apoptosis Induced by 188Re-DTPA-DG in MCF-7 Breast Carcinoma and A549 Pulmonary Carcinoma Cells

Abstract: 188Re-DTPA-DG has a significant apoptotic effect on carcinoma cells. 188Re-DTPA-DG is an effective radiopharmaceutical for intratumoral radiation therapy.

Cited by 6 publications

References 11 publications

Preliminary Studies of 177Lu-Diethylenetriamine Penta-Acetic Acid-Deoxyglucose in Hepatic Tumor-Bearing Mice

Preliminary Studies of 177Lu-Diethylenetriamine Penta-Acetic Acid-Deoxyglucose in Hepatic Tumor-Bearing Mice

Molecular Imaging Kits for Hexosamine Biosynthetic Pathway in Oncology

18F-FDG and Other Labeled Glucose Derivatives for Use in Radionuclide Diagnosis of Oncological Diseases (Review)

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Study of Apoptosis Induced by ¹⁸⁸Re-DTPA-DG in MCF-7 Breast Carcinoma and A549 Pulmonary Carcinoma Cells

Preliminary Studies of ¹⁷⁷Lu-Diethylenetriamine Penta-Acetic Acid-Deoxyglucose in Hepatic Tumor-Bearing Mice

Preliminary Studies of ¹⁷⁷Lu-Diethylenetriamine Penta-Acetic Acid-Deoxyglucose in Hepatic Tumor-Bearing Mice