Study of antiurolithiatic activity of Asparagus racemosus on albino rats

Abstract

Aims:The aim of this study was to investigate the effect of ethanolic extract of Asparagus racemosus on urolithiasis in rats.Materials and Methods:Thirty-six male Wistar albino rats were randomly divided into six groups (n = 6). Ethylene glycol (EG) 0.75% and ammonium chloride (AC) 2% in drinking water were fed to all groups (Groups II–VI) except normal control (Group I) rats for 10 days to induce urolithiasis. Group III–VI rats were treated with ethanolic extract of Asparagus racemosus at doses 200, 400, 800, and 1600 mg/kg, respectively, for 10 days. Positive control (Group II) rats were treated with EG/AC alone. Group I rats were administered drinking water and distilled water (6 μl/g) by gavage. After 10 days, blood samples were collected and analyzed for serum concentrations of calcium, phosphorus, urea, and creatinine. The kidneys were removed and sectioned for histopathological examination. The data were presented as mean ± standard error of mean and analyzed using one-way analysis of variance and Student's “t”-test. P < 0.05 was considered statistically significant. Conventional windows software was used for statistical analysis.Results:The rats treated with ethanolic extract of A. racemosus at doses 800 and 1600 mg/ kg significantly (P < 0.05) reduced the serum concentrations of calcium, phosphorus, urea, and creatinine. Histopathology of the kidneys in Groups V and VI revealed less tissue damage and were almost similar to Group I rats.Conclusions:The ethanolic extract of A. racemosus has protective effect against urolithiasis.

Nephrocalcinosis induced by hyperoxaluria in rats

“…Although serum creatinine is not considered an ideal biomarker of glomerular filtration rate (GFR), it can be used to estimate overall renal function in the absence of more sensitive markers 23 . Some authors have reported a correlation between decreased renal function and urolithiasis due to urinary obstruction and damage of the renal parenchyma 24,25 . In this study,…”

“…However, when the animals were followed for 28 days, there was no statistical difference in serum creatinine in the different groups. Considering that the prolonged period of exposure to different inducing agents could cause deterioration in the renal function 25 , normal levels of creatinine at M2 suggests that the initial statistical difference observed in M1 could be considered a biological variation.…”

A Comprehensive Glimpse on Globally Used Antiurolithiatic Plants of Convolvulaceae, Costaceae, Ebenaceae, Fagaceae, Hypericaceae, Lauraceae, Liliaceae and Lythraceae

“…[5] Antiurolithiatic spectrum (reported): Roots against whewellite. [35] Asphodelus aestivus Brot. Dioscorides (De Materia Medica): Roots are diuretic [22] ; Aerial parts ---Turkey.…”

Protective Effect of Root Extract of Nothosaerva Brachiata Wight in Ethylene Glycol Induced Urolithiatic Rats

“…Ethylene glycol induced urolithiasis model was used for the experiment [9][10] . The model was customized for 15 days of study.…”