Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation

Kataoka, Takahiro

doi:10.1093/jrr/rrs141

Cited by 62 publications

(58 citation statements)

References 68 publications

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“…Many of these effects persisted at 9 months. Our results are in accordance with some reports showing the anti-inflammatory effect of low-dose irradiation [51,61] and of low dose radiotherapy (<1Gy or fractionated) [62][63][64].…”

Section: Discussionsupporting

confidence: 93%

Chronic internal exposure to low dose 137CS induces positive impact on the stability of atherosclerotic plaques by reducing inflammation in APOE-/- MICE

et al. 2015

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After Chernobyl and Fukushima Daï Chi, two major nuclear accidents, large amounts of radionuclides were released in the environment, mostly caesium 137 ( 137 Cs). Populations living in contaminated territories are chronically exposed to radionuclides by ingestion of contaminated food. However, questions still remain regarding the effects of low dose ionizing radiation exposure on the development and progression of cardiovascular diseases. We therefore investigated the effects of a chronic internal exposure to 137 Cs on atherosclerosis in predisposed ApoE -/-mice. Mice were exposed daily to 0, 4, 20 or 100 kBq/l 137 Cs in drinking water, corresponding to range of concentrations found in contaminated territories, for 6 or 9 months. We evaluated plaque size and phenotype, inflammatory profile, and oxidative stress status in different experimental groups. Results did not show any differences in atherosclerosis progression between mice exposed to 137 Cs and unexposed controls. However, 137 Cs exposed mice developed more stable plaques with decreased macrophage content, associated with reduced aortic expression of pro-inflammatory factors (CRP, TNFα, MCP-1, IFNγ) and adhesion molecules (ICAM-1, VCAM-1 and E-selectin). Lesions of mice exposed to 137 Cs were also characterized by enhanced collagen and smooth muscle cell content, concurrent with reduced matrix metalloproteinase MMP8 and MMP13 expression. These results suggest that low dose chronic exposure of 137 Cs in ApoE -/-mice enhances atherosclerotic lesion stability by inhibiting pro-inflammatory cytokine and MMP production, resulting in collagen-rich plaques with greater smooth muscle cell and less macrophage content.

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Section: Discussionsupporting

confidence: 93%

Chronic internal exposure to low dose 137CS induces positive impact on the stability of atherosclerotic plaques by reducing inflammation in APOE-/- MICE

et al. 2015

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“…37 Unfortunately, in our experimental setting we cannot provide data about wild-type mice irradiated with 0.5 Gy. However, as proposed by Kataoka et al 38 and others low-dose radiation rather activates the anti-oxidative defense systems in the body, than induces oxidative stress and therefore contributes to preventing or reducing ROS-related injuries. In contrast, enhanced oxidative stress and reduced oxidative capacity is one hallmark in A-T patients and the deficiency to counteract ROS-induced DNA damage also contributes to the phenotype in Atm-deficient mice.…”

Section: Discussionmentioning

confidence: 94%

Low-dose irradiation prior to bone marrow transplantation results in ATM activation and increased lethality in Atm-deficient mice

Pietzner¹,

Merscher²,

Baer³

et al. 2016

Bone Marrow Transplant

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Ataxia telangiectasia is a genetic instability syndrome characterized by neurodegeneration, immunodeficiency, severe bronchial complications, hypersensitivity to radiotherapy and an elevated risk of malignancies. Repopulation with ATM-competent bone marrow-derived cells (BMDCs) significantly prolonged the lifespan and improved the phenotype of Atm-deficient mice. The aim of the present study was to promote BMDC engraftment after bone marrow transplantation using low-dose irradiation (IR) as a coconditioning strategy. Atm-deficient mice were transplanted with green fluorescent protein-expressing, ATM-positive BMDCs using a clinically relevant non-myeloablative host-conditioning regimen together with TBI (0.2-2.0 Gy). IR significantly improved the engraftment of BMDCs into the bone marrow, blood, spleen and lung in a dose-dependent manner, but not into the cerebellum. However, with increasing doses, IR lethality increased even after low-dose IR. Analysis of the bronchoalveolar lavage fluid and lung histochemistry revealed a significant enhancement in the number of inflammatory cells and oxidative damage. A delay in the resolution of γ-H2AX-expression points to an insufficient double-strand break repair capacity following IR with 0.5 Gy in Atmdeficient splenocytes. Our results demonstrate that even low-dose IR results in ATM activation. In the absence of ATM, low-dose IR leads to increased inflammation, oxidative stress and lethality in the Atm-deficient mouse model.

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“…Electronic products emitted the light causes damage to the retina by free radical attacks, which is a common phenomenon [3,7].…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to ultraviolet (UV) A and short-wavelength visible radiation, from environment, may induce the production of reactive oxygen species (ROS) and result in oxidative damage to RPE cells [1,2,3]. Oxidative injury and functional impairment may act an early and important role in the development of age-related macular degeneration (AMD) [2,4,5,6], Previous studies have indicated that damage to RPE through photochemical mechanisms by free radical reactions is driven by photo-excited, endogenous chromophores through the cornea and lens [2].…”

Section: Introductionmentioning

confidence: 99%

Food Supplements Were Applied to the Mitochondrial Capacity of Retinal Cells and Oxidative Phosphorylation of Adenosine Triphosphate (ATP) Synthesis

Yang¹,

Tu²,

Cheng³

et al. 2017

JFNR

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The retina consists of many different cells, the most important of which are retinal cells. Retinal cells have a lot of mitochondria. The mitochondria in retinal cells provide the energy of retinal cell activity, including the energy required to convert light into nerve signals. However, when the sun enters the eye and is irradiated on the retina, the high-energy ultraviolet light in the solar energy causes the mitochondria in the retinal cells and retinal cells to produce free radicals. These free radicals are detrimental to retinal cells and mitochondrial intima. Long-term accumulation, in addition to free radicals directly to the damage caused by retinal cells, the serious damage to the mitochondrial intima can also cause mitochondrial decomposition, and then lead to retinal cell apoptosis. This study discloses an eye care method comprising the provision of Phyllanthus emblica extract for the use of retinal cells in the late stage of ultraviolet or ultraviolet irradiation to obtain mitochondria in retinal cells of chlorophyll extract for oxidative phosphoric acid (ATP) synthesis Higher than the mitochondria, without Phyllanthus emblica extract of retinal cells, and with triphosphate (ATP) for phosphorylation. According to the above method, the supply of Phyllanthus emblica extract retinal cells protects the inner membrane of mitochondria in retinal cells, thereby delaying the decomposition time of mitochondria, adding Phyllanthus emblica extract can also reduce the free radical content of retinal cells such as bamboo leaf extract can slow Mitotic decomposition caused by the rate of apoptosis and can reduce the effectiveness of retinal cells due to excessive free radical content and damage to protect retinal cells to achieve eye care.

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Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation

Cited by 62 publications

References 68 publications

Chronic internal exposure to low dose 137CS induces positive impact on the stability of atherosclerotic plaques by reducing inflammation in APOE-/- MICE

Chronic internal exposure to low dose 137CS induces positive impact on the stability of atherosclerotic plaques by reducing inflammation in APOE-/- MICE

Low-dose irradiation prior to bone marrow transplantation results in ATM activation and increased lethality in Atm-deficient mice

Food Supplements Were Applied to the Mitochondrial Capacity of Retinal Cells and Oxidative Phosphorylation of Adenosine Triphosphate (ATP) Synthesis

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