Study of antioxidant activity of fullerenols by inhibition of adrenaline autoxidation

Dubinina, Irina A.; Kuzmina, E M; Dudnik, A. I.; Vnukova, Natalia G.; Чурилов, Г. Н.; Samoylova, Nataliya A.

doi:10.17586/2220-8054-2016-7-1-153-157

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Some fullerene derivatives, which mainly include tris-malonyl C 60 (C 3 ) and polyhydroxy fullerene (fullerenols), have excellent antioxidative activity via scavenging free radicals. − Fullerenols, which have attached hydroxyl groups (−OH) on fullerene cages, have moderate water solubility and biocompatibility. − Chiang et al first found that fullerenols have potential antioxidative properties by which they can scavenge superoxide radical anions (O 2 •– ) generated by xanthine and the xanthine oxidase system . This is especially true for C 60 (OH) 22 , which can scavenge 1 O 2 , O 2 •– , and • OH .…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Antioxidant Activities of Fullerenols from First-Principles Calculation

2018

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Fullerenols possess excellent antioxidant activity, in which they can scavenge all of the major physiologically relevant reactive oxygen species (ROS). However, the underlying ROS-scavenging mechanisms of C60 fullerenols are not completely understood. Using density functional theory calculations, we investigated •OH-, O2 •–-, and H2O2-scavenging mechanisms of C60 fullerenols and the correlations between hydroxyl distributions and radical-scavenging ability. For scavenging •OH and O2 •–, H• donation and electron transfer via hydrogen bonds, respectively, are the dominant mechanisms for C60 fullerenols. Although the obtained fullerenols simultaneously contain radicals and anions, there is an isolated OH anion which possesses the activity of eliminating H2O2. The •OH-scavenging activity depends on the distribution of hydroxyls according to the calculations for ten C60(OH)24 isomers. Fullerenols, in which the distribution of hydroxyls leads to low redox potential (ε) values, possess high scavenging activity. For the nonmagnetic fullerenols, activity relies on the number of sp2 substructures, in which the greater their number is, the lower the activity of the fullerenols. The results will be of fundamental importance in understanding the antioxidant activities of fullerenols.

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Section: Introductionmentioning

confidence: 99%

Mechanisms of Antioxidant Activities of Fullerenols from First-Principles Calculation

2018

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“…However, fullerenes are hydrophobic, which limits the possibilities of their direct use in biomedicine [193] It is possible to obtain their aqueous dispersions [194][195][196][197][198][199][200] and associates with organic compounds [200][201][202][203][204][205]. One of the ways of modifying the surface of fullerenes provides hydroxylated derivatives such as fullerenols [195,200,205,206,208]. The specific functionalization of their surface is achieved through the use of amphiphilic polymers, amino acids, carboxylic acids, and biologically active preparations that identify molecules [206,207].…”

Section: Carbon-based Nanostructured Systemsmentioning

confidence: 99%

“…The absorption of such systems by cells can be realized through specific endocytosis. Another possible trend in the use of fullerenes is the creation of bioactive [203,204,206,208] or contrast materials for nuclear magnetic resonance imaging (MRI) through internal functionalization by contrast agents, including Gd 3+ , Sc 3+ , Ho 3+ , Tm 2+ , Ga 3+ and Tc 2+ ions, with isolation of unstable and potentially toxic contrast materials from the internal medium of the body [209][210][211][212]. A similar solution for creating contrast materials is proposed in [213] for Keplerates, the non-carbon analogs of fullerenes which form ionic associates with cations of the above-mentioned metals.…”

Section: Carbon-based Nanostructured Systemsmentioning

confidence: 99%

The use of nanocluster polyoxometalates in the bioactive substance delivery systems

Остроушко¹,

Gagarin²,

Данилова³

et al. 2019

Nanosystems: Phys. Chem. Math.

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Nanoscale systems occupy the most important place among the vehicles intended for targeted drug delivery. Such vehicles are considered in this review. Attention is paid to the nanocluster polyoxometalate-based systems which are promising for transdermal iontophoretic transport. In this relation, and due to the characteristics of the skin as a transport medium, the problems of the transfer processes modeling are considered.

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Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

Ostroushko¹,

Grzhegorzhevskii²,

Medvedeva³

et al. 2021

Nanosystems: Phys. Chem. Math.

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The paper discusses the results of a research on physicochemical and biochemical properties of the Keplerate-type molybdenum-based nanocluster polyoxometalates (POMs), which show promise in the field of biomedicine as a means of targeted drug delivery, including the transport to immune privileged organs. POMs can be considered as components of releasing systems, including the long-acting ones with feedback (for controlling the drug active component release rate). POMs are promising drugs for the treatment of anemia. Also, the paper deals with the results of studies of POM effect on living systems at the molecular and cellular levels, at that of individual organs, and on the organism as a whole. The mechanism and kinetics of POM destruction and possibilities of stabilization, the oscillatory phenomena manifestation, the formation of POM conjugates with bioactive substances which can be released during the destruction of POM, with polymer components, and with indicator fluorescent dyes, as well as forecasts for further research, are considered.

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Study of antioxidant activity of fullerenols by inhibition of adrenaline autoxidation

Cited by 4 publications

References 7 publications

Mechanisms of Antioxidant Activities of Fullerenols from First-Principles Calculation

Mechanisms of Antioxidant Activities of Fullerenols from First-Principles Calculation

The use of nanocluster polyoxometalates in the bioactive substance delivery systems

Physicochemical and biochemical properties of the Keplerate-type nanocluster polyoxomolybdates as promising components for biomedical use

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