Study of antimutagenic and antioxidant activities of Gallic acid and 1,2,3,4,6-pentagalloylglucose from Pistacia lentiscus

Abdelwahed, A.; Bouhlel, Inès; Skandrani, Inès; Valenti, Kita; Kadri, Malika; Guiraud, Pascal; Steiman, R.; Mariotte, Anne‐Marie; Ghedira, Kamel; Laporte, François; Dijoux‐Franca, Marie‐Geneviève; Chekir‐Ghedira, Leila

doi:10.1016/j.cbi.2006.10.003

Cited by 196 publications

(129 citation statements)

References 28 publications

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“…These are known to have activity against four of the six tested bacteria, B. cereus, E. coli, E. faecalis and S. aureus (Fiamegos et al 2011;Lou et al 2011). Gallic acid is a trihydroxybenzoic acid with high antioxidant potential and anti-mutagenic potential that potentiates the expression of antioxidant-related and DNA repairing enzymes (Abdelwahed et al 2007). Its effect on protecting diabetic-induced rats was also demonstrated (Punithavathi et al 2011).…”

Section: Antioxidant Activity Phenolic Profile and Trace Elementsmentioning

confidence: 99%

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Nunes

Paśko

Tyszka-Czochara

et al. 2016

Pharmaceutical Biology

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Context: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. Objective: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. Material and methods: Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW). Antioxidant activity was measured with TAA, FRAP and RP methods. Phenolics were quantified with a HPLC. Zinc was quantified using voltammetry. Antibacterial activity (after 48 h) was tested using Enterococcus faecalis, Bacillus cereus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Listeria monocytogenes. Antiproliferative activity (after 24 h) was tested using HEP G2 cells and fibroblasts. Results: Solvents influenced results; the best were E and 80EW. GP had the highest antioxidant activity (TAA and FRAP of 536.90 mg AAE/g dw and 783.48 mg TE/g dw, respectively). CM had the highest zinc concentration (37.21 mg/kg) and phenolic variety, with neochlorogenic acid as the most abundant (92.91 mg/100 g dw). LS was rich in rosmarinic acid (301.71 mg/100 g dw). GP and LS inhibited the most microorganisms: B. cereus, E. coli and S. aureus. GP also inhibited E. faecalis. CM had the lowest MIC: 5830 lg/mL. The antibacterial activity is explained by the phenolics present. LS and CM showed the most significant anti-proliferative activity, which is explained by their zinc content. Conclusion: The most promising plants for further studies are CM, LS and GP.ARTICLE HISTORY

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Section: Antioxidant Activity Phenolic Profile and Trace Elementsmentioning

confidence: 99%

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Nunes

Paśko

Tyszka-Czochara

et al. 2016

Pharmaceutical Biology

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“…It exhibits multiple biological activities, including anti-inflammatory (10), anti-mutagenic (11), anti-cancer (12), antioxidant (13), anti-bacterial (14), and antiviral effects. Many studies have reported that PGG can inhibit the replication of HSV-1 (15), respiratory syncytial virus (16), hepatitis B virus (17), and influenza virus (18).…”

Section: Introductionmentioning

confidence: 99%

Pentagalloylglucose Blocks the Nuclear Transport and the Process of Nucleocapsid Egress to Inhibit HSV-1 Infection

Jin

Chen

et al. 2016

Jpn J Infect Dis

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SUMMARY: Herpes simplex virus type 1 (HSV-1), a widespread virus, causes a variety of human viral diseases worldwide. The serious threat of drug-resistance highlights the extreme urgency to develop novel antiviral drugs with different mechanisms of action. Pentagalloylglucose (PGG) is a natural polyphenolic compound with significant anti-HSV activity; however, the mechanisms underlying its antiviral activity need to be defined by further studies. In this study, we found that PGG treatment delays the nuclear transport process of HSV-1 particles by inhibiting the upregulation of dynein (a cellular major motor protein) induced by HSV-1 infection. Furthermore, PGG treatment affects the nucleocapsid egress of HSV-1 by inhibiting the expression and disrupting the cellular localization of pEGFP-UL31 and pEGFP-UL34, which are indispensable for HSV-1 nucleocapsid egress from the nucleus. However, the over-expression of pEGFP-UL31 and pEGFP-UL34 could decrease the antiviral effect of PGG. In this study, for the first time, the antiviral activity of PGG against acyclovir-resistant virus was demonstrated in vitro, and the possible mechanisms of its anti-HSV activities were identified based on the inhibition of nuclear transport and nucleocapsid egress in HSV-1. It was further confirmed that PGG could be a promising candidate for HSV therapy, especially for drug-resistant strains.

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“…18 Os flavonóides são relatados como antioxidantes por sua capacidade de capturar várias espécies oxidantes, como os radicais hidroxila ou peróxido. [19][20][21] A busca por antioxidantes naturais, principalmente para utilização na indústria alimentícia, devido a sua baixa toxicidade quando comparados com os produtos sintéticos, como terc-butil-4-metoxifenol (BHA) ou 2,6-di-tercbutil-4-metilfenol (BHT) 22 nos motivou a buscar novas fontes potenciais de antioxidantes derivados de plantas abundantes no Nordeste brasileiro.…”

Section: Introductionunclassified

Estudo químico e biológico de Tephrosia toxicaria Pers.

Vasconcelos¹,

Lima²,

Lemos³

et al. 2009

Quím. Nova

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Recebido em 27/3/08; aceito em 23/9/08; publicado na web em 2/2/09 CHEMICAL AND BIOLOGICAL STUDY OF THE Tephrosia toxicaria Pers. The ethanol extracts from leaves, stems, pods and roots were assayed against the 3 rd instar Aedes aegypti larvae and the highest activity was observed in the roots extracts (LC 50 47.86 ppm). This extract was submitted to partition with hexane, chloroform, ethyl acetate and methanol. The respective fractions were bioassayed and the best larvicidal activities were identified in the hexane (LC 50 23.99 ppm) and chloroform (LC 50 13.80 ppm) fractions. Antioxidant activity (DDPH method) was observed in the ethanol extract (IC 50 276 µg/mL) from roots of T. toxicaria. Fractions from this extract were also tested and the highest antioxidant activity (IC 50 89 µg/mL) was found in the methanol fraction. The flavonoids iso-obovatin (1), obovatin (2), 6a,12a-dehydro-β-toxicarol (3), 6a,12a-dehydro-α-toxicarol (4) and α-toxicarol (5) were isolated and bioassayed against A. aegypti. The flavonoid 5 showed the best larvicidal activity (LC 50 24.55 ppm). The antioxidant activity of 2 was investigated and showed IC 50 3.370 µg/mL. The antioxidant and larvicidal activities of Tephrosia toxicaria are reported for the first time.Keywords: Tephrosia toxicaria; flavonoids; biological activity. iNtRoduÇÃoO gênero Tephrosia, família Leguminoseae Papilionoideae (Fabaceae), possui aproximadamente trezentas espécies, distribuídas em regiões tropicais e subtropicais.1 Espécies deste gênero apresentam capacidade biogenética para produzir substâncias com grande diversidade estrutural, tais como esteróides, aminoácidos e flavonóides, incluindo os isoflavonóides rotenóides.2 Estes últimos são conhecidos por apresentarem as atividades ictiotóxica 3 e larvicida. 4 Outras atividades biológicas importantes, como anti-tumoral e antiviral, aparecem também descritas na literatura. 5,6Tephrosia toxicaria Pers., popularmente conhecida por "timbó de caiena" ou "anil", é utilizada para capturar peixes 7 e o extrato aquoso de suas raízes é aplicado como defensivo agrícola em hortas orgânicas na localidade de Guaraciaba do Norte -CE. A literatura relata o isolamento e atividade anticâncer de compostos isolados de T. toxicaria, 8,9 bem como a composição química e atividade larvicida de seu óleo essencial. 10A busca por substitutos para os inseticidas sintéticos tem produzido muitos trabalhos científicos, contemplando inclusive a utilização de extratos ou constituintes ativos provenientes de plantas.10-15 Esta procura pode ser justificada pela fácil degradação destes constituintes, menor toxicidade ao homem e, conseqüen-temente, representa uma alternativa mais segura para o meio ambiente.15 Estas observações, aliadas à crescente incidência da febre dengue -endêmica nas Américas, 16 sendo diagnosticados de 50 a 100 milhões de casos por ano 17 -nos estimularam adicionalmente para uma prospecção química em T. toxicaria, com o objetivo de encontrar compostos sucedâneos aos larvicidas sintéticos utilizados no combate ao Aedes aegypt...

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Study of antimutagenic and antioxidant activities of Gallic acid and 1,2,3,4,6-pentagalloylglucose from Pistacia lentiscus

Cited by 196 publications

References 28 publications

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Antibacterial, antioxidant and anti-proliferative properties and zinc content of five south Portugal herbs

Pentagalloylglucose Blocks the Nuclear Transport and the Process of Nucleocapsid Egress to Inhibit HSV-1 Infection

Estudo químico e biológico de Tephrosia toxicaria Pers.

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