Study of Antimicrobial Power of Amphoteric Disinfectants of Tego Series Used in Pharmaceutical Industry

Eissa, Mostafa Essam; Kamel, Mohab Abd El Naby; Beshir, Mohamed Mohamed

doi:10.21608/eajbsg.2014.16626

Cited by 4 publications

(5 citation statements)

References 6 publications

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“…The test was adopted from USP, 9 and carried out as detailed in the study by Eissa et al 4 The peroxygen biocidal agent stock solution (denoted by: Codas) composition was as follows; hydrogen peroxide 27%, peracetic acid 4.5% and inert ingredients 68.5%. This stock solution was diluted to the working concentration by purified water USP in sterile containers prior to the test.…”

Section: Effectiveness As Antimicrobial Agentmentioning

confidence: 99%

“…That is why in sanitization and disinfection program it is preferable to use a sporicidal agent on a less frequent basis in complementation with less aggressive disinfectants such as Isopropyl alcohol 70% or Ethanol 70% and Tego 51 or 2000 1%. 4 Also, the concentration of sporicidal agent must be chosen carefully in order to attain an optimum sporicidal activity in reasonable time. The test protocol used in a disinfectant qualification study varies from one company to another, since the procedures are usually customized to reflect the types of surfaces and application of the chemical products at a particular facility.…”

Section: Introductionmentioning

confidence: 99%

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Bacterial vs. fungal spore resistance to peroxygen biocide on inanimate surfaces

Eissa¹,

Naby²,

Beshir³

2014

Bulletin of Faculty of Pharmacy, Cairo University

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A sporicidal agent formula based on a mixture of peroxyacetic acid and hydrogen peroxide was assessed for its efficacy on a representative sample of vinyl surface material. Vinyl is the construction material of wall and floor lining in pharmaceutical plants. The experimental manipulations; applied herein, simulated the actual biocidal agent preparation and were carried out using USP purified water, test temperature was 20-25°C, RH% was 40-60% and pH was 3.08 and 2.86 for 1% and 2% (v/v) respectively. Following the selection of the optimum method of antimicrobial activity neutralization, two disinfectant concentrations were examined for their sporicidal activity. The results of carrier test revealed that the disinfectant concentration (2%) (v/v) was significantly effective as a sporicidal agent after 5 and 10 min for Aspergillus brasiliensis and Bacillus subtilis subsp. spizizenii, respectively, while the concentration of 1% (v/v) did not achieve even one logarithmic reduction after 20 min. The agent was able to achieve more than 100 times reduction from the initial bioburden on the surfaces when used in the concentration of 2% (v/v) after 10 min of contact time. The ideal kinetics of microbial death usually follows 2 parts (by averaging the responses with time for the 3 replicates): initial slow rate of death followed by higher rate. The initial sigmoidal part was only observed with B. subtilis upon exposure to 2% (v/v) sporicidal agent. Elimination time for B. subtilis spores was 15 min which was about double the time required for eradication of A. brasiliensis.ª 2014 Production and hosting by Elsevier B.V. on behalf

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Section: Effectiveness As Antimicrobial Agentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bacterial vs. fungal spore resistance to peroxygen biocide on inanimate surfaces

Eissa¹,

Naby²,

Beshir³

2014

Bulletin of Faculty of Pharmacy, Cairo University

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“…Disinfectant surface challenge test was done according to Eissa et al, 2014 in triplicates. The test was based on inoculating coupon surface material with10 5 to 10 6 CFU approximately then applying disinfectant at different contact times.…”

Section: Disinfectant Qualification Studymentioning

confidence: 99%

Assessment of Antimicrobial Activity of Novel Disinfectant Based on Peroxygen/Biguanide/Alcohol Combination

Eissa

2014

Indonesian J. Pharm.

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A new disinfectant formula based on combination of Hydrogen peroxide 0.6g%, Chlorohexidine gluconate 0.5g% and Isopropanol 70.5g% was investigated to be used as broad spectrum disinfectant in an attempt to make better control over microbial bioburden in clean area during critical processes. A proper neutralization method was first implemented using combination of dilution 1:10 (v/v) and chemical inactivation method using LBC3T then disinfectant efficacy study was conducted using surface challenge test and finally compatibility with other disinfectants was performed to ensure that there is no adverse interaction between them. This new product demonstrated more than 3 log reduction (LR) in less than one minute against tested vegetative bacteria and yeast Bacillus subtilis (>4.68, >4.81, >3.85 and >4.88), Pseudomonas aeruginosa (>4.00, >4.34, >3.85 and >4.04) Candida albicans (>4.11, >4.18, >4.95 and >4.48), Micrococcus lylae (>5.56, >5.56, >5.65 and 5.74) and Leifsonia aquaticum (>5.82, 5.79, >5.75 and >5.74) but about 15min were needed to achieve high log reduction against Aspergillus niger (3.02, 2.94, 2.91 and 3.10) and no remarkable log reduction of bacterial spores of Bacillus subtilis and Bacillus pumilus even after 30min of contact time on coupons inoculated with microorganisms. There is no interaction between this new formula and any other commonly used disinfectants in pharmaceutical facility. The new disinfectant may be used as sanitizer with good activity but not as sporicidal agent for up to 30min contact time.

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“…For pharmaceutical facilities, and to lesser extent healthcare facilities, the floors are additionally cleansed with disinfectants and/or detergents such as benzalkonium chloride (and other quaternary ammonium compounds), hydrogen peroxide, sodium hypochlorite, and other alternatives (Murtough et al, 2001;Sandle, 2012;Eissa et al, 2014;Han et al, 2021;Tembo et al, 2022). While debated in efficacy (Daschner et al, 1982;Meyer and Cookson, 2010;Suleyman et al, 2018), the surface cleaning agents are often rotated in these facilities to minimize potential microbial resistance and/or selection toward the cleaning conditions (Murtough et al, 2001;Sandle, 2012).…”

Section: Introductionmentioning

confidence: 99%

The Impact of the Space Environment on Microbial Growth and Behavior

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Study of Antimicrobial Power of Amphoteric Disinfectants of Tego Series Used in Pharmaceutical Industry

Cited by 4 publications

References 6 publications

Bacterial vs. fungal spore resistance to peroxygen biocide on inanimate surfaces

Bacterial vs. fungal spore resistance to peroxygen biocide on inanimate surfaces

Assessment of Antimicrobial Activity of Novel Disinfectant Based on Peroxygen/Biguanide/Alcohol Combination

The Impact of the Space Environment on Microbial Growth and Behavior

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