Study of Antiepileptic Effect of Pentazocine And Combination Of Pentazocine With Phenytoin In Experimentally Induced Convulsions In Albino Rats

Abstract

Aims& objectives: The present study was designed to compare the anti convulsant effect of pentazocine with standard phenytoin sodium and also combination of different doses of pentazocine with different doses of phenytoin in experimentally induced albino rats. Materials& methods: 30 albino rats of either sex weighing 150 to 200 gms were selected and randomly divided in to 5 equal groups with 6 rats in each group, maximal electro shock seizures(MES) were induced in albino rats via trans auricular electrodes (150 mA,0.2 seconds) each rat was pretreated at 30 minutes before MES test with drugs intraperitoneally. Statistical Analysis: Descriptive data that include Mean, Standard Deviation, and standard error value were found for each group and used for analysis. One way ANOVA was used for multiple group comparison. P value of 0.05 or less was considered for statistical significant. Resuts: intraperitoneal administration of pentazocine resulted in reduction of different phases of convulsions during MES method. Different dose combination of pentazocine &phenytoin also reduced the duration of different phases of convulsions Conclusion: the anticonvulsant effect of pentazocine alone is superior to the effect of combination of pentazocine and phenytoin in the seizure models. Pentazocine alone was comparable to that of the standard drug in electrically induced seizures .