Study of anti nuclear and anti smooth muscle antibodies in patients with chronic obstructive pulmonary disease

Gouda, Tahany M.; Yousof, Ayman A.; Salahy, Mahmoud M. Al; mehy, Gehan F. Al; Essawy, Tarek S.; El-Shaer, Osama S.

doi:10.1016/j.ejcdt.2013.11.001

Cited by 3 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 20 ] Some studies have shown diagnostic accuracy and elevated level of SMA in patients with AIH and chronic abstractive pulmonary disease. [ 23 42 43 ]…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis

Rafeey

Saboktakin

Hasani

et al. 2016

Afr J Paediatr Surg

View full text Add to dashboard Cite

Background:We aimed to evaluate the diagnostic value of anti-smooth muscle antibodies (ASMA) and two liver markers (gamma-glutamyl transpeptidase [GGT] and alkaline phosphatase [ALP]) for differentiating between patients with extrahepatic biliary atresia (EHBA) and idiopathic neonatal hepatitis (INH).Materials and Methods:During April 2010–2011, all infants at 2 weeks of age who were diagnosed with cholestasis and admitted to Children's Hospital of Tabriz were enrolled. Based on the results of physical examination, laboratory, imaging and pathological studies, neonates were divided into two groups (EHBA and INH). Receiver operating characteristics analysis was used to define sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for ASMA, GGT and ALP.Results:Thirty neonates with cholestasis (18 with EHBA and 12 with INH) and mean age of 54.66 ± 25.86 days were enrolled. Total and direct bilirubin, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase and ASMA titres were highly not significant (P > 0.05) in patients with INH. GGT (P = 0.008) and ALP (P = 0.01) had statistically significant differences that were higher in patients with EHBA. The sensitivity, specificity, PPV and NPV, accuracy, LR+ and LR− of SMA in differentiating cases with BA were 66.7%, 75%, 80% 60%, 70%, 2.68 and 0.44, respectively. For GGT, the values were 88.9%, 66.7%, 80%, 80%, 79.1%, 3.08 and 0.31, respectively. Finally, for ALP, the values were 77.8%, 75%, 82.4%, 69.2%, 80%, 2.66 and 0.24, respectively.Conclusion:Our study showed that ASMA may be a useful biomarker for differentiation of EHBA from INH. Further studies with larger samples are recommended for confirming the results of this study.

show abstract

“…[ 20 ] Some studies have shown diagnostic accuracy and elevated level of SMA in patients with AIH and chronic abstractive pulmonary disease. [ 23 42 43 ]…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis

Rafeey

Saboktakin

Hasani

et al. 2016

Afr J Paediatr Surg

View full text Add to dashboard Cite

show abstract

Autoantibodies in chronic obstructive pulmonary disease: A systematic review

et al. 2019

View full text Add to dashboard Cite

Set Up for Failure: Pre-Existing Autoantibodies in Lung Transplant

et al. 2021

View full text Add to dashboard Cite

Lung transplant patients have the lowest long-term survival rates compared to other solid organ transplants. The complications after lung transplantation such as primary graft dysfunction (PGD) and ultimately chronic lung allograft dysfunction (CLAD) are the main reasons for this limited survival. In recent years, lung-specific autoantibodies that recognize non-HLA antigens have been hypothesized to contribute to graft injury and have been correlated with PGD, CLAD, and survival. Mounting evidence suggests that autoantibodies can develop during pulmonary disease progression before lung transplant, termed pre-existing autoantibodies, and may participate in allograft injury after transplantation. In this review, we summarize what is known about pulmonary disease autoantibodies, the relationship between pre-existing autoantibodies and lung transplantation, and potential mechanisms through which pre-existing autoantibodies contribute to graft injury and rejection.

show abstract

Study of anti nuclear and anti smooth muscle antibodies in patients with chronic obstructive pulmonary disease

Cited by 3 publications

References 28 publications

Diagnostic value of anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis

Diagnostic value of anti-smooth muscle antibodies and liver enzymes in differentiation of extrahepatic biliary atresia and idiopathic neonatal hepatitis

Autoantibodies in chronic obstructive pulmonary disease: A systematic review

Set Up for Failure: Pre-Existing Autoantibodies in Lung Transplant

Contact Info

Product

Resources

About