Study of anti-inflammatory, analgesic and antipyretic activities of seeds of Hyoscyamus niger and isolation of a new coumarinolignan

Begum, Shahnaz; Saxena, Bhagawati; Goyal, Madhur; Ranjan, Rakesh; Joshi, Vijaya B.; Rao, Ch. V.; Krishnamurthy, Sairam; Sahai, Mahendra

doi:10.1016/j.fitote.2009.08.024

Cited by 75 publications

(39 citation statements)

References 20 publications

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“…Its etiology includes production of prostaglandins, which set the thermoregulatory center at a higher temperature. Most of the antipyretic drugs like aspirin or paracetamol inhibit COX-2 expression to reduce the elevated body temperature by inhibiting PgE2 biosynthesis [28][29][30][31][32] .…”

Section: Discussionmentioning

confidence: 99%

Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb.

Sasmal¹,

Majumdar²,

Gupta³

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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Section: Discussionmentioning

confidence: 99%

Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb.

Sasmal¹,

Majumdar²,

Gupta³

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

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“…18 The results showed the antipyretic effect of the two extract types, the ethanol extract being more pronounced in comparison to the reference substances LAS and hydrocortisone.…”

Section: Discussionmentioning

confidence: 91%

Anti-inflammatory Activities of Total Leaf Extracts of Ficus sycomorus L. (Moraceae) used in Traditional Medicine in the Treatment of Sickle Cell Disease

Ramde-Tiendrebeogo¹,

Ouédraogo²,

Tibiri³

et al. 2015

JYP

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Background: This study has been carried out to evaluate the in vivo anti-inflammatory, analgesic and anti-pyretic effects of an aqueous decoction and ethanol extract (95%) of Ficus sycomorus leaves. Methods: The anti-inflammatory effect was evaluated by the carrageenan-induced mice paw oedema model. The non-morphine type analgesic effect was evaluated trough acetic acid-induced writhing test. The morphine type analgesic activity was tested by mouse tail-flick test. The anti-pyretic activity was tested by induced hyperthermia in mice with brewer's yeast. Data analysis used the one way ANOVA test. Results: The anti-inflammatory effects of the two extracts, at doses of 300 and 500 mg/kg b.w., were dose dependent and comparable to those of the reference controls, indomethacin (1 mg/kg b.w.) and hydrocortisone (10 mg/kg b.w.). At the same dose, the analgesic effect of the ethanol extract on abdominal writhings induced by acetic acid, was comparable to those Lysine acetylsalicylate (LAS, 300 mg/kg b.w) and hydrocortisone (10 mg/kg b.w.) used as controls. As for the morphine type analgesic effects of the two extracts tested at doses of 300 and 500 mg / kg both were significantly higher in comparison with the blank control (p<0.05) and comparable to that of morphine (5 mg/kg b.w.) from the 75 th minute. The antipyretic activity of the extracts at the same doses was comparable to those of the LAS (300 mg/ kg b.w.) and hydrocortisone (10 mg/kg b.w.) from the third hour. Conclusion: The results obtained justify the use of the plant in traditional medicine and show the significance of Ficus sycomorus leaves in the search for new anti-inflammatory molecules in the treatment of sickle cell disease.

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“…Edema formation results from the synergistic action of inflammatory mediators such as histamine, serotonin and bradykinin produced under the effect of cycloxygenase-2 (COX-2) at the site of a local inflammatory insult leading to increased vascular permeability and blood flow. 15,16 Edema formation due to egg albumin in the rat paw is a biphasic event; the early phase of edema, which begins immediately after the administration of the irritant and lasting up to 2 h, is probably due to the release of histamine and serotonin. While the latter phase, occurring from 3 to 5 h after the administration of the irritant is induced by bradykinin, protease, prostaglandins and lysosome.…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats

Akram¹,

Benkiki²,

Eddine³

et al. 2018

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Objectives:This study was aimed to explore the antipyretic and anti-inflammatory effects of n-butanol etract of Atractylis flava Desf (A. flava) using experimentally induced inflammation and pyrexia models in rats. Methods: In the acute toxicity study, a single oral dose of 2000 mg/kg of n-butanol extract was given to rats. The antipyretic activity was evaluated using brewer's yeast induced pyrexia in rats. In addition, albumin induced rat paw edema was performed by the injection of 100 µL undiluted fresh egg albumin to assess the anti-inflammatory effects of the plant. Results: The results of the present study revealed that n-butanol extract of A. flava significantly (P<0.001) reduced fresh egg albumin-induced rat paw edema and also inhibited fever significantly in brewer's yeast induced pyrexia. Conclusion: The results of the present study indicated that A. flava possesses antipyretic and anti-inflammatory activity in the models studied.

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Study of anti-inflammatory, analgesic and antipyretic activities of seeds of Hyoscyamus niger and isolation of a new coumarinolignan

Cited by 75 publications

References 20 publications

Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb.

Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb.

Anti-inflammatory Activities of Total Leaf Extracts of Ficus sycomorus L. (Moraceae) used in Traditional Medicine in the Treatment of Sickle Cell Disease

Anti-Inflammatory, Anti-pyretic and Acute Toxicity Effects of n-Butanol Extract of Atractylis flava Desf in Rats

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