Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm.f.) Nees and their effects on gene expression

Parichatikanond, Warisara; Suthisisang, Chuthamanee; Dhepakson, Panadda; Herunsalee, Angkana

doi:10.1016/j.intimp.2010.08.002

Cited by 87 publications

(71 citation statements)

References 47 publications

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“…Sheeja et al 36) reported that Andrographis paniculata extract could inhibit inflammation induced by carageenan in a mouse model. Some compounds isolated from Andrographis paniculata exhibit an anti-inflammatory property, such as andrographolide 37) or andrograpanin. 38) Astragalus membranaceus saponins upregulate the PC pathway, exhibiting protection of endothelium or antithrombotic activity.…”

Section: Discussionmentioning

confidence: 99%

Xiang-Qi-Tang Increases Avian Pathogenic Escherichia coli-Induced Survival Rate and Regulates Serum Levels of Tumor Necrosis Factor Alpha, Interleukin-1 and Soluble Endothelial Protein C Receptor in Chicken

Shen

et al. 2011

Biological & Pharmaceutical Bulletin

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Xiang-Qi-Tang (XQT) is a Chinese herbal formula containing Rhizoma Cyperi, Andrographis paniculata and Astragalus membranaceus. The present study investigated the effects of XQT on the mortality and inflammatory mediators in a chicken model challenged with avian pathogenic Escherichia coli (APEC). To detect the effect of XQT, the chickens were pretreated with the formula 12 h before being challenged with 10 8 colony forming unit (CFU) of APEC. The results showed that 0.6 g/kg XQT significantly elevated the survival rate of infected chickens. To further investigate the mechanism of decreasing mortality of XQT, we examined plasma inflammatory mediator levels. The levels of tumor necrosis factor alpha (TNF-a a), interleukin-1 (IL-1) and soluble endothelial protein C receptor (sEPCR) were significantly increased in chickens challenged with APEC alone, whereas chickens pretreated with 0.6 g/kg XQT showed marked decrease of these inflammatory mediator levels during the death peak. Taken together, this study demonstrates that XQT has protective effects in APEC-treated chickens. The action mechanisms of XQT involve anti-inflammation and antithrombotic activity. These findings may contribute to future research on the action mechanisms of this formula, as well as prevention of or therapy for avian colibacillosis.

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Section: Discussionmentioning

confidence: 99%

Xiang-Qi-Tang Increases Avian Pathogenic Escherichia coli-Induced Survival Rate and Regulates Serum Levels of Tumor Necrosis Factor Alpha, Interleukin-1 and Soluble Endothelial Protein C Receptor in Chicken

Shen

et al. 2011

Biological & Pharmaceutical Bulletin

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“…Preclinical properties include anti-retroviral [6,7], antiproliferative and pro-apoptotic [8,9], anti-diabetic [10,11], anti-angiogenic [12], anti-thrombotic [13], anti-urothelial [14], anti-leishmaniasis [15], hepatoprotective [16,17], protective activity against alcohol-induced hepatic and renal toxicity [18], and cardioprotective [19] and anti-inflammatory [20][21][22][23][24][25] …”

Section: Andrographis Paniculata and Labdane Diterpenoidsmentioning

confidence: 99%

“…The structure of neoandrographolide ( Figure 2) was described as a diterpene glucoside and its amount in the plant is around 0.5-1%. The main preclinical effects are anti-inflammatory [23,26,27], chemosensitizer [28], anti-herpes-simplex virus [7] and antioxidant [29].…”

Section: Neoandrographolidementioning

confidence: 99%

Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease

Hidalgo¹,

Hancke²,

Bertoglio³

et al. 2013

Innovative Rheumatology

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“…In addition, ATP is an important extracellular signaling molecule that is released from cells during particular physiologic and pathologic processes, such as neurotransmission, hypotonic stress and cell injury due to inflammation and tumor necrosis [10,11]. anticancer, anti-allergic and anti-stress effects [19][20][21][22][23].…”

mentioning

confidence: 99%

Anti-stress Effects of Tunisian Cymbopogon schoenanthus L. Ethanol Extract and Some of Its Active Compounds

Othman¹,

Neffati²,

Isoda³

2017

JAST-A

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Many antioxidant rich phytochemical extracts are attracting interest as stress adaptogens. In this regard, several plants are used traditionally and clinically for the management of neurologic disorders. Here, the anti-stress properties of the ethanol extract of medicinal plant Cymbopogon schoenanthus (CSEE), which grows wild in Southern Tunisia, were investigated, as well as the effects of some of the extracted active compounds on H 2 O 2 -induced cytotoxicity, overproduction of reactive oxygen species (ROS) and adenosine triphosphate (ATP) depletion in human neuroblastoma SH-SY5Y cells. Whereas fluorescence intensity due to DCFH-DA (a marker of ROS production) in H 2 O 2 -treated SH-SY5Y cells was greater than that in untreated control cells, pretreatment with CSEE and its active compounds ameliorated H 2 O 2 -induced ROS production. Moreover, H 2 O 2 at 150 µM significantly decreased intracellular ATP levels in SH-SY5Y cells, and pretreatment with CSEE and its active compounds buffered this effect. These in vitro results demonstrate the potential of CSEE to protect against stress-associated disorders.

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Study of anti-inflammatory activities of the pure compounds from Andrographis paniculata (burm.f.) Nees and their effects on gene expression

Cited by 87 publications

References 47 publications

Xiang-Qi-Tang Increases Avian Pathogenic Escherichia coli-Induced Survival Rate and Regulates Serum Levels of Tumor Necrosis Factor Alpha, Interleukin-1 and Soluble Endothelial Protein C Receptor in Chicken

Xiang-Qi-Tang Increases Avian Pathogenic Escherichia coli-Induced Survival Rate and Regulates Serum Levels of Tumor Necrosis Factor Alpha, Interleukin-1 and Soluble Endothelial Protein C Receptor in Chicken

Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease

Anti-stress Effects of Tunisian Cymbopogon schoenanthus L. Ethanol Extract and Some of Its Active Compounds

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