Study of Anti-atopic Dermatitis Effects of Juice of Raphanus sativus var in HaCaT Cell Line

이승제,; 임은경,; 김가연,; 전미지,; 김상용,; 김영민,; 유제근,

doi:10.7841/ksbbj.2017.32.4.311

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Looking at recent research trends, research into the regulation of microbial communities is increasingly shifting towards postbiotics. Numerous studies have demonstrated the potential of natural products and probiotics to bolster immune regulation in AD-like keratinocyte models, although the clinical outcomes have often not met expectations [ 15 , 19 , 20 ]. Postbiotics are emerging as a promising alternative to address these shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Response of New Postbiotics in TNF-α/IFN-γ-Induced Atopic Dermatitis-like HaCaT Keratinocytes

Kim,

Cho,

Kang

2024

CIMB

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This study examines the synergistic interaction between the immunomodulatory functions of lactic acid bacteria postbiotics and the anti-inflammatory properties of Smilax china L. extract through a combined fermentation process. Using atopic dermatitis (AD) as a model, characterized by an immune imbalance that leads to skin inflammation, we developed a fermented product, MB-2006, and compared its effects to those of the heat-killed probiotics Lactobacillus acidophilus (LAC) and Lactobacillus rhamnosus (LRH). Our experiments focused on elucidating the mechanism of action of MB-2006 in AD-like HaCaT keratinocyte cells, particularly its impact on the NF-κB pathway, a pivotal regulator of inflammation. MB-2006 proved more effective in reducing inflammation markers, such as IL-4 and thymic stromal lymphopoietin (TSLP), and in inhibiting NF-κB activation compared to LAC and LRH. Significantly, MB-2006 also reduced the expression of thymus- and activation-regulated chemokine (TARC), highlighting a synergistic effect that enhances its therapeutic potential. These results suggest that the combined fermentation of Smilax china L. extract with lactic acid bacteria enhanced both the anti-inflammatory and immunomodulatory effects, presenting a promising integrative approach to treating conditions like AD. Further studies are needed to validate these results in clinical settings and fully explore the potential of this synergistic fermentation process.

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Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Response of New Postbiotics in TNF-α/IFN-γ-Induced Atopic Dermatitis-like HaCaT Keratinocytes

Kim,

Cho,

Kang

2024

CIMB

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“…Looking at recent research trends, research into the regulation of microbial communities is increasingly shifting towards postbiotics. Numerous studies have demonstrated the potential of natural products and probiotics to bolster immune regulation in AD-like keratinocyte models, although the clinical outcomes have often not met expectations [20,44,45]. Postbiotics are emerging as a promising alternative to address these shortcomings.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Response of a New Postbiotics in TNF-α/IFN-γ-Induced Atopic Dermatitis-Like HaCaT Keratinocytes

Kim,

Cho,

Kang

2024

Preprint

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This study examines the synergistic interaction between the immunomodulatory functions of lactic acid bacteria postbiotics and the anti-inflammatory properties of Smilax China L. extract through a combined fermentation process. Using atopic dermatitis (AD) as a model, characterized by an immune imbalance that leads to skin inflammation, we developed a fermented product, MB-2006, and compared its effects to those of heat-killed probiotics, Lactobacillus acidophilus (LAC) and Lac-tobacillus rhamnosus (LRH). Our experiments focused on elucidating the mechanism of action of MB-2006 in AD-like HaCaT keratinocyte cells, particularly its impact on the NF-kB pathway, a pivotal regulator of inflammation. MB-2006 proved more effective in reducing inflammation markers such as IL-4 and thymic stromal lymphopoietin (TSLP), and in inhibiting NF-kB activation, compared to LAC and LRH. Significantly, MB-2006 also reduced the expression of thymus- and activation-regulated chemokine (TARC), highlighting a synergistic effect that enhances its thera-peutic potential. These results suggest that the combined fermentation of Smilax china L. extract with lactic acid bacteria enhanced both the anti-inflammatory and immunomodulatory effects, pre-senting a promising integrative approach to treating conditions like AD. Further studies are needed to validate these results in clinical settings and fully explore the potential of this synergistic fer-mentation process.

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Effect of thiazolidinedione phenylacetate derivatives on wound-healing activity

Park

Choi²,

Cho

2018

Arch. Pharm. Res.

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The aim of this work was to evaluate the synthesis and structure-activity relationship of 4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl 2-phenylacetate derivatives as potential wound-healing agents. The IC values of the lead compounds ranged from 0.01 to 0.05 µM. These compounds also increased the levels of extracellular prostaglandin E (PGE) in A549 cells. Among the synthesized compounds, compounds 66, 67, 69, and 86 increased PGE levels 3- to 4-fold of those achieved with the negative control. Introduction of a halogen at the intermediate phenyl ring, compounds 66, 67, 69, and 86 resulted in higher IC values, which indicated lower cytotoxicity than that observed upon the introduction of other substituents at the same position. In particular, cells exposed to compound 69 showed significantly improved wound healing, and the wound closure rate achieved was approximately 3.2-fold higher than that of the control. Therefore, compound 69 can be used for tissue regeneration and treatment of diverse diseases caused by PGE deficiency. Overall, our findings suggested that compound 69 might be a novel candidate for skin wound therapy.

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Study of Anti-atopic Dermatitis Effects of Juice of Raphanus sativus var in HaCaT Cell Line

Cited by 3 publications

References 12 publications

Anti-Inflammatory Response of New Postbiotics in TNF-α/IFN-γ-Induced Atopic Dermatitis-like HaCaT Keratinocytes

Anti-Inflammatory Response of New Postbiotics in TNF-α/IFN-γ-Induced Atopic Dermatitis-like HaCaT Keratinocytes

Anti-inflammatory Response of a New Postbiotics in TNF-α/IFN-γ-Induced Atopic Dermatitis-Like HaCaT Keratinocytes

Effect of thiazolidinedione phenylacetate derivatives on wound-healing activity

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