Study of anterior commissure-posterior commissure distance among Nepalese cohort

Abstract

Introduction: The main aim of this study is to determine the anterior commissure-posterior commissure (AC-PC) distance in Nepalese cohort and has comparison of intercommissural distance of Nepalese cohort with some other races. Materials and Methods: The 47 patients, with mean age of 50 years, included in the study had undergone DBS or lesioning (Pallidotomy). Data were collected through the magnetic resonance imaging under DBS protocol and the manipulation, marking of AC and PC was done in Inomed Planning Software (IPS). Results: The data revealed average AC-PC distance of Nepalese cohort to be 24.86 ± 2.08 mm, ranging from 16 mm to 30 mm. The study among 29 males and 18 females illustrated male to have longer AC-PC as compared to female (25.38 mm male and 24.02 mm female). The results also confirmed age related changes in AC-PC distance which was linearly increasing with the age. Conclusion: Comparison of data from other studies revealed Nepalese cohort to have almost similar AC-PC distance with Asian population, while that was longer in Caucasian and shorter in Hispanic Population.

Engineering and Innovations in Neurosurgery

“…Although there is a single institute, Annapurna Neurological Institute and Allied sciences have been performing DBS and Pallidotomy, more than 80 patients with PD and other movement related disorder (essential tremor, dystonia, and task specific focal dystonia) have been treated with this sophisticated technology. 30,31 Recently the modern and the advanced form of DBS, has been researched and is being used as clinical trials known as Magnetic Resonance Imaging Guided Focused Ultrasound (MRgFUS). MRgFUS is based on the principle of DBS, which aims the portion or the nucleus in the basal ganglia or any other structure in the brain using a MRI image and the targeted location is stimulated via a focused beam of ultrasound.…”