Study of Anaemia in Type II Diabetes Mellitus in Relation to Glycemic Control

Bhargav, Karan; Baruah, K.; Agrawal, Pramod Kumar; Alam, Faiyaz; Sonal, Shruti; Kumar, Abhisek; Dubey, Yogesh Kumar

doi:10.21276/iabcr.2016.2.4.7

Cited by 3 publications

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“…35 This study indicated that the odds of developing anemia among respondents with poor glycemic control were three times more likely as compared with respondents with good glycemic control. This is comparable with findings in Nigeria, 78 India, 58 Pakistan 30 and Kuwait. 35 Because erythropoietin synthesis and release are controlled in part by the autonomic nervous system, 22,25 and diabetic autonomic neuropathy is common in a condition of poor glycemic control, 79,80 the results propose that erythropoietin synthesis could be prematurely inhibited in patients with poor glycemic control.…”

Section: %supporting

confidence: 89%

“…Normocytic normochromic blood picture was the most common morphological types of anemia found in this study. It is not surprising to see normocytic normochromic blood picture of anemia in this study, as various previous studies conducted in China, 57 Malaysia, 54,55 India, 58,59 and Iraq, 60 also revealed this situation. Since the participants of this study were DM patients, anemia of chronic disease is expected, which is normocytic normochromic in morphology.…”

Section: Discussionsupporting

confidence: 76%

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<p>Anemia and Its Associated Factors Among Type 2 Diabetes Mellitus Patients Attending Debre Berhan Referral Hospital, North-East Ethiopia: A Cross-Sectional Study</p>

Taderegew¹,

Gebremariam²,

Tareke³

et al. 2020

JBM

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Purpose: Anemia is one of the common complications of diabetes mellitus (DM), which has an adverse effect on the progression and development of other diabetes-related complications. In spite of this, relatively little information is available on the prevalence of anemia and associated factors among type 2 diabetes mellitus (T2DM) patients in Ethiopia, particularly in the study area. Thus, this study assessed the prevalence of anemia and associated factors among T2DM patients at Debre Berhan Referral Hospital (DBRH), NorthEast , Ethiopia. Patients and Methods: A hospital-based cross-sectional study was conducted from April 1 to May 30, 2019, among 249 T2DM patients with follow up at DBRH, selected using a systematic random sampling technique. Data were collected by face-to-face interviews, anthropometric measurements, and laboratory tests; such as hemoglobin measurements, red blood indices, and serum creatinine analysis. The data were coded and entered into Epi-data manager version 4.4.1.0, and analysis by using SPSS version 22 was carried out. To identify the determinant factors of anemia, bivariate and multivariate logistic regression analyses were performed. P-value <0.05 was considered as statistically significant. Results: The study showed 20.1% of the participants were anemic. Being age >60 years (AOR=3.06, 95% CI: 1.32-7.11), poor glycemic control (AOR=2.95, 95% CI: 1.22-7.15), eGFR 60-89.9 mL/min/1.73m 2 (AOR=2.91, 95% CI: 1.15-7.37), eGFR <60 mL/min/1.73m 2 (AOR=6.58, 95% CI: 2.42-17.93), DM duration >10 years (AOR= AOR=2.75, 95% CI: 1.17-6.48), and having diabetic complications (AOR=3.81, 95% CI: 1.65-8.81) were significantly associated with anemia. Conclusion: One out of five T2DM patients had anemia. Poor glycemic control, decreased eGFR, presence of DM complications, duration of DM >10 years, and age >60 years were significantly associated with the occurrence of anemia among T2DM. Regular screening for anemia in all T2DM patients may help in the early detection and management of anemia.

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Section: %supporting

confidence: 89%

Section: Discussionsupporting

confidence: 76%

<p>Anemia and Its Associated Factors Among Type 2 Diabetes Mellitus Patients Attending Debre Berhan Referral Hospital, North-East Ethiopia: A Cross-Sectional Study</p>

Taderegew¹,

Gebremariam²,

Tareke³

et al. 2020

JBM

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“…Our study is in correlation with the study of Bhargava Karan [24],Babatunde Ishola Adejuno,Katherine J. Craig, which states that there is significant prevalence of anaemia in diabetic patients as compared to non-diabetics and anaemia is higher among uncontrolled diabetic patients.…”

Section: Discussion:-supporting

confidence: 86%

Anaemia: Unrecognized Risk Factor in Type Ii Diabetes Mellitus.

Anjum¹,

Phatale²

2018

IJAR

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Introduction: Diabetes has reached epidemic proportion in the world and anaemia is increasingly recognised entity in patients with diabetes mellitus .Studies have shown that anaemia is twice as common in diabetes as compared to non-diabetic subjects. Aim: The aim of our study is to determine the prevalence of anaemia in type-II diabetes and to assess its association with degree of glycaemic control with respect to HbA1c. Material and method: 30 diabetic male patients with 30 normal male subjects of age group 40-60 years. Result: Our study showed statistically significant decrease in haemoglobin concentration as the level of HbA1cincreased in the uncontrolled diabetic patients without any diabetic nephropathy. Conclusion: Regular screening of anaemia along with blood glucose levels should be mandatory in diabetic patients to prevent further complications.

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“…Anaemia was present in 40% of diabetics and majority was in the age group between 50-60 years and majority of anaemia was normocytic (66%) as compared to microcytic (29%). 5 Another study done by Adejumo et al in 2012 showed that incidence of anaemia was 15.3% in participants with diabetes without renal insufficiency. The study added that patients who have poorly controlled diabetes were at higher risk of anaemia than those with controlled diabetes.…”

Section: Discussionmentioning

confidence: 96%

“…4 Many factors have been suggested as the reason for the earlier onset of anaemia in patients with diabetes, including severe symptomatic autonomic neuropathy, causing efferent sympathetic denervation of the kidney and loss of appropriate erythropoietin production; damage to the renal interstitium, systemic inflammation; and inhibition of erythropoietin release. 5 In spite of the plethora of reports on the presence of anaemia in diabetic patients with renal insufficiency, limited study exists on the incidence of anaemia in diabetics prior to the evidence of renal impairment. This may explain why most diabetic patients with normal renal function are rarely tested for anaemia.…”

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confidence: 99%

A comparative study of anaemia with the degree of glycaemic control in type 2 diabetes mellitus

Prabhu

Teli

2019

Int J Adv Med

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Background: Anaemia is one of the world’s most common preventable condition yet it is often overlooked especially in people with Diabetes Mellitus. Anaemia is a common finding in patients with diabetes. Anaemia in patients with diabetes mellitus might contribute to the pathogenesis and progression of cardiovascular disease and aggravate diabetic nephropathy and retinopathy. This aims to study the correlation between HbA1c and blood glucose levels in anaemic diabetics in order to assess the influence of anaemia on HbA1c and the effect of severity and type of anaemia on HbA1c.Methods: It’s a case control study, 200 Diabetic subjects were divided into two groups of 100 each based on their HbA1c levels group A, with good glycaemic control (HbA1c<7) and group B with poor glycaemic control (HbA1c>7), incidence of anaemia was measured and compared among them and also with 100 age and sex matched healthy non Diabetic controls. Results: In this study, it was found that high incidence of anaemia was found significantly higher in diabetics group with poor glycaemic control. Anemia was detected in 55% of patients among diabetic patients. Anaemia was seen in 71% of patients in group B with poor glycaemic control as compared to group A with good glycaemic control, in which only 39% of patients had anaemia. Mean haemoglobin was significantly lower that is, 10.81±3.0 in group with poor glycaemic control as compared to group with good glycaemic control i.e. 13.04±2.02. There was a statistically significant negative correllation between Haemoglobin percentage and HbA1c.Conclusion: Anaemia is a common finding in patients with diabetes. Diabetes related chronic hyperglycaemia can lead to a hypoxic environment in the renal interstitium which results in impaired production of erythropoietin by the peritubular fibroblasts and subsequently anaemia occurs. Anaemia in patients with diabetes mellitus might contribute to pathogenesis and progression of cardiovascular disease and aggravate diabetic nephropathy and retinopathy. However, an emphasis on regular screening for anaemia, alongside that for other diabetes related complications, might help to delay the progression of vascular complication in these patients.

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Study of Anaemia in Type II Diabetes Mellitus in Relation to Glycemic Control

Cited by 3 publications

References 0 publications

<p>Anemia and Its Associated Factors Among Type 2 Diabetes Mellitus Patients Attending Debre Berhan Referral Hospital, North-East Ethiopia: A Cross-Sectional Study</p>

<p>Anemia and Its Associated Factors Among Type 2 Diabetes Mellitus Patients Attending Debre Berhan Referral Hospital, North-East Ethiopia: A Cross-Sectional Study</p>

Anaemia: Unrecognized Risk Factor in Type Ii Diabetes Mellitus.

A comparative study of anaemia with the degree of glycaemic control in type 2 diabetes mellitus

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