Study of Anaemia and Iron Profile in the Subjects with Vitamin D Deficiency Comparison with Healthy Controls without Vitamin D Deficiency

Abstract

Introduction: Iron and vitamin D are two essential nutrients which constitute an important worldwide health issue due to their significant roles in biochemistry. The present study was conducted to assess the prevalence and risk of anemia in a population of subjects with documented D25 deficiency compared with those with normal D25 levels. Material and Methods: The present case control study was conducted among 100 subjects (50 were cases and 50 were controls) in the department of Medicine at Chattrapati Shivaji Subharti Hospital. Total serum 25(OH)D concentration was analyzed using commercially available ELISA kits. According to the manufacturer's instructions, concentrations of 25(OH)D below 25 nmol/L were classified as a deficiency, and values of 25-75 nmol/L were considered a vitamin D insufficiency. Difference between two groups was determined using chi square test and student T test for categorical data and continuous data respectively. P-value of <0.05 was considered as significant. Results: Hb<13 was found in 75% of the case group (male) and 25% of the control group (male). Hb<12 was found in 64.29% of the case group (female) and 45.45% of the control group (female). Mean iron (μg/dl) among the male and female case group was less as compared to the control group with statistically significant difference as p<0.05. Conclusions: The results of the present study showed that Vitamin D metabolism is dependent on iron and its deficiency might disturb Vitamin D activation.